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Riluzole-loaded Nanoparticles To Alleviate The Symptoms Of Neurological Disorders By Attenuating Oxidative Stress

Bushra Nabi, Saleha Rehman, M. Fazil, S. Khan, S. Baboota, J. Ali
Published 2020 · Medicine, Chemistry

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Abstract Purpose: The objective of the research undertaken was to develop the Riluzole (RIZ) nanoparticles drug delivery system using Transferrin (Tf) as a ligand in the brain. Method: RIZ-loaded chitosan nanoparticles and RIZ-Tf chitosan (CS) nanoparticles (RIZ CSNPs and RIZ-Tf CSNPs) were formulated and compared for particles size, size distribution, encapsulation efficiency, and surface morphology, respectively. The in vitro drug release, permeation, pharmacokinetic, biochemical, and pharmacodynamic experiments were done to assess the improvement in in vivo fate and efficacy of RIZ. Results: The size of optimized RIZ CSNPs was found to be 173.6 ± 2.23 nm and polydispersity index (PDI) of 0.264 ± 0.002 while that of RIZ-Tf CSNPs was 207 ± 2.49 nm and 0.406 ± 0.002. In vitro release was found to be 86.15 ± 7.316% and 91.1 ± 5.836%, respectively, while permeability coefficient was found to be 4 × 10−2 and 4.2 × 10−2 cm/s for RIZ CSNPs and RIZ-Tf CSNPs. The biochemical analysis studies revealed that oxidative stress was significantly decreased in case of RIZ CSNPs and RIZ-Tf CSNPs (p < 0.01) treated groups. The antianxiety effect and the memory restoration were evident in pharmacodynamic studies (p < 0.05) of the prepared formulations. Conclusion: The results of pharmacokinetic studies demonstrated the remarkable brain delivery of RIZ-Tf CSNPs through intranasal route as compared to the RIZ solution.
This paper references
Central nervous system diseases and the role of the blood-brain barrier in their treatment
A. Domínguez (2013)
Kinetic modeling on drug release from controlled drug delivery systems.
Suvakanta Dash (2010)
Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
Devin T. Wiley (2013)
Potential of nanoparticulate drug delivery systems by intranasal administration.
J. Ali (2010)
Development and characterization of atorvastatin calcium loaded chitosan nanoparticles for sustain drug
A Bathool (2012)
Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection
Julien Maincent (2017)
Development and in vitro characterization of chitosan-coated polymeric nanoparticles for oral delivery and sustained release of the immunosuppressant drug mycophenolate mofetil
M. Mohammed (2019)
Recent advances in ligand targeted therapy
G. Trapani (2012)
Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir
Saleha Rehman (2017)
Simple determination of riluzole in rat brain by high-performance liquid chromatography and spectrophotometric detection.
A. Maltese (2005)
The intranasal gels of Box-Behnken experimental design for preparation and optimization of selegiline hydrochloride
S Salatin (2018)
Preparation of surface multiple-coated polylactide acid drug-loaded nanoparticles for intranasal delivery and evaluation on its brain-targeting efficiency
Junjie Bian (2016)
Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease
Qingqing Meng (2018)
Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block
Alessandra Cifra (2011)
Intranasal dolutegravir sodium loaded nanoparticles of hydroxypropyl-beta-cyclodextrin for brain delivery in Neuro-AIDS
A. Belgamwar (2019)
Synthesis and characterization of silver nanoparticles embedded in polyaniline nanocomposite
Y. Wankhede (2013)
Venlafaxine loaded chitosan NPs for brain targeting: pharmacokinetic and pharmacodynamic evaluation.
S. Haque (2012)
Development of zolmitriptan transfersomes by Box–Behnken design for nasal delivery: in vitro and in vivo evaluation
Shravan Kumar Pitta (2018)
Kedare Rahul Vitthal (2012)
Intranasal nanoemulsion based brain targeting drug delivery system of risperidone.
M. Kumar (2008)
Protein measurement with the Folin phenol reagent.
O. H. Lowry (1951)
Generalized anxiety disorder: diagnosis and treatment
E. Hoge (2012)
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.
H. Ohkawa (1979)
Development and characterization of atorvastatin calcium loaded chitosan nanoparticles for sustain drug delivery
Afifa Bathool (2012)
Formulation and biopharmaceutical evaluation of risperidone-loaded chitosan nanoparticles for intranasal delivery
Rajalakshmi Rukmangathen (2019)
Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting.
M. Fazil (2012)
Depressive Disorders in Indian Context : A Review and Clinical Update for Physicians.
R. D. Pattanayak (2014)
Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique.
W. Fan (2012)
Nanoparticles: An Advance Technique for Drug Delivery
Kuldeep Malodia (2012)
Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat.
T. Mcintosh (1996)
Controversies and priorities in amyotrophic lateral sclerosis
M. Turner (2013)
Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: pharmacodynamic, pharmacokinetic and scintigraphy study in mice model.
Shadab Md (2013)
Brain targeted nanoparticulate drug delivery system of rasagiline via intranasal route
Deepti Mittal (2016)
Chitosan and chitosan: ethylene oxide-propylene oxide block copolymer 482 B. NABI ET AL. NPs as novel carriers for proteins and vaccines
P Calvo (1997)
Novel instantlydispersible nanocarrier powder system (IDNPs) for intranasal delivery of dapoxetine hydrochloride: in-vitro optimization, ex-vivo permeation studies and in-vivo evaluation
SA Fouad (2018)
Complexation as an approach to entrap cationic drugs into cationic nanoparticles administered intranasally for Alzheimer's disease management: preparation and detection in rat brain
A. Hanafy (2015)
Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies.
Shrinidh A Joshi (2010)
Nanoparticle: An overview of preparation and characterization
S. Pal (2011)
Riluzole elevates GLT-1 activity and levels in striatal astrocytes
M. Carbone (2012)
Venlafaxine loaded chitosan nanoparticles for brain targeting: pharmacokinetic and pharmacodynamic evaluation
S Haque (2012)
Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting
H. Mahajan (2014)
Synthesis and Optimization of Chitosan Nanoparticles Loaded with l-Ascorbic Acid and Thymoquinone
N. Othman (2018)
Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates.
C. Kast (2001)
Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines
P. Calvo (2004)
Brain-targeted intranasal zaleplon solid dispersion in hydrophilic carrier system; 23 full-factorial design and in vivo determination of GABA neurotransmitter
E. Abd-Elrasheed (2018)
In vitro and in vivo evaluation of cubosomal in situ nasal gel containing resveratrol for brain targeting
Mayuri Ahirrao (2017)
Design, characterization, and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting
Omidreza Jafarieh (2015)
Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles
L. Zhang (2013)
Solid lipid nanoparticles for nose to brain delivery of haloperidol: in vitro drug release and pharmacokinetics evaluation
Mohd Yasir (2014)
Novel instantly-dispersible nanocarrier powder system (IDNPs) for intranasal delivery of dapoxetine hydrochloride: in-vitro optimization, ex-vivo permeation studies, and in-vivo evaluation
Shahinaze A Fouad (2018)
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.
J. Sedlak (1968)
Chitosan nanoparticles loaded with dorzolamide and pramipexole
Sofia A. Papadimitriou (2008)
Curcumin-Eudragit® E PO solid dispersion: A simple and potent method to solve the problems of curcumin.
J. Li (2015)
Fabrication, Optimization, and Evaluation of Rotigotine-Loaded Chitosan Nanoparticles for Nose-To-Brain Delivery
A. S. Tzeyung (2019)
Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability
J. A. Kulkarni (2017)
Synthesis and in vitro evaluation of a novel thiolated chitosan.
K. Kafedjiiski (2005)
Box–Behnken experimental design for preparation and optimization of the intranasal gels of selegiline hydrochloride
S. Salatin (2018)
Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies.
U. Seju (2011)
Formulation of intranasal mucoadhesive temperature-mediated in situ gel containing ropinirole and evaluation of brain targeting efficiency in rats
S. Khan (2010)
Pharmacological investigation of memory restorative effect of riluzole in mice
P. Rinwa (2012)
Surface‐functionalized nanoparticles for targeted gene delivery across nasal respiratory epithelium
Sneha Sundaram (2009)

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