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Hypochlorhydria From Short-term Omeprazole Treatment Does Not Inhibit Intestinal Absorption Of Calcium, Phosphorus, Magnesium Or Zinc From Food In Humans.

C. Serfaty-Lacrosniere, R. Wood, D. Voytko, J. Saltzman, M. Pedrosa, T. Sepe, R. R. Russell
Published 1995 · Chemistry, Medicine
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OBJECTIVE Low gastric pH is generally believed to be an important factor in intestinal mineral absorption. Thus, hypochlorhydria could be an important risk factor for mineral malabsorption and the development of marginal mineral status. We studied whether the hypochlorhydria associated with treatment with the anti-ulcer medication omeprazole, a potent gastric proton pump inhibition, would affect intestinal calcium, phosphorus, magnesium, or zinc absorption from food. METHODS Thirteen normal, healthy adults were assigned to either a control group (n = 5) receiving no drug treatment or an omeprazole treatment group (n = 8) to produce increased gastric pH. Omeprazole treatment of normal volunteers resulted in a significant change in postprandial gastric pH (pH 6.4 +/- 0.3 vs. 3.6 +/- 0.5 in control subjects, p < 0.01) and baseline fasting pH (pH 5.8 +/- 0.5 vs. pH 1.8 +/- 0.3 in controls, p < 0.01) after an overnight fast. Net mineral absorption from a standard test meal was measured using a whole gut lavage technique. Mineral absorption was measured twice in each subject, once with 120 mL of 0.1 mol/liter hydrochloric acid and a second time with 120 mL of distilled water alone. RESULTS We found that despite marked changes in gastric pH due to drug treatment or administration of exogenous HCl, no change in the intestinal absorption of calcium, phosphorus, magnesium or zinc from a standard test meal was evident. CONCLUSIONS These findings suggest that changing the gastric pH alone does not modify the net intestinal absorption of several minerals from food. Therefore, it is unlikely that moderate hypochlorhydria resulting from short-term omeprazole treatment substantially increases the risk for developing calcium, phosphorus, magnesium, or zinc deficiencies due to mineral malabsorption.



This paper is referenced by
Proton pump inhibitors are now massively utilized medications worldwide but their H + ,K + -ATPase and non-H + ,K + -ATPase mediated side effects are poorly appreciated
J. Mullin (2009)
10.1002/ncp.10181
Proton Pump Inhibitors: Risks and Rewards and Emerging Consequences to the Gut Microbiome.
Amandeep Singh (2018)
10.1038/sj.ejcn.1601333
Magnesium bioavailability from mineral water. A study in adult men
Maximilian Verhas (2002)
10.1007/978-88-470-1357-5_4
Nutrizione e prevenzione del rischio di osteoporosi
Alessandro Medina Pinto (2009)
10.1016/j.metabol.2012.09.011
Proton pump inhibitors have no measurable effect on calcium and bone metabolism in healthy young males: a prospective matched controlled study.
Ala I Sharara (2013)
10.1517/14740338.2013.797961
Indications and safety of proton pump inhibitor drug use in patients with cancer
George Triadafilopoulos (2013)
10.1002/9780470987025.CH14
Metabolic Bone Disease in Gastrointestinal Disorders
Ann Cranney (2010)
10.1016/B978-0-12-415784-2.00006-3
Gastrointestinal Tract and the Control of Bone Mass
Thorsten Schinke (2013)
10.3390/ijms20205203
Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility
R. Fossmark (2019)
10.1053/J.GASTRO.2013.08.038
REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Peter J. Kahrilas (2013)
10.4291/wjgp.v5.i4.496
Zinc and gastrointestinal disease.
Sonja M. Skrovanek (2014)
10.1152/physrev.00015.2012
Gastric acid, calcium absorption, and their impact on bone health.
Sascha Kopic (2013)
10.1007/s00198-012-2112-9
The effect of proton pump inhibitors on fracture risk: report from the Canadian Multicenter Osteoporosis Study
L-A. Fraser (2012)
Medical therapy of GERD and NERD The severity of symptoms does not correlate with the presence or with severity of subtypes of GERD (
Smout AJPM (2012)
10.4137/CMT.S4500
Gastric Acid-Related Diseases: Focus on Esomeprazole
Bandar Aljudaibi (2010)
10.1016/J.MONRHU.2011.01.005
Ostéoporose et inhibiteurs de pompe à protons
Christian Roux (2011)
10.1016/J.REVMED.2011.12.011
Effets indésirables des inhibiteurs de la pompe à proton : faut-il craindre de les prescrire au long cours ?
Lucien Roulet (2012)
10.1002/9781444314403.CH16
16. Metabolic Bone Disease in Gastrointestinal Disorders
Ann Cranney (2010)
10.1097/MOG.0b013e32833ff5d6
Proton pump inhibitors and severe hypomagnesaemia
T. F. Cundy (2011)
Severe hypomagnesemia refractory to oral supplementation associated to omeprazole treatment
Franchini (2017)
10.1053/j.gastro.2017.01.031
The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association.
Daniel E Freedberg (2017)
Are Proton Pump Inhibitors Suitable Medicines to Prevent Gastrointestinal Events Due to Non-steroidal Anti-inflammatory Drugs?
Katsuhiro Toda (2018)
10.1053/j.gastro.2009.12.007
Hip fracture risk in patients with a diagnosis of pernicious anemia.
N. Merriman (2010)
10.1007/s00424-013-1306-0
Omeprazole enhances the colonic expression of the Mg2+ transporter TRPM6
Anke L L Lameris (2013)
10.1177/0004563213517628
Contemporary view of the clinical relevance of magnesium homeostasis
John Ayuk (2014)
Population-based studies on risk of fracture in patients with neurological disorders
Sander Pouwels (2014)
10.3390/pharmaceutics10010036
Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
Emily S Mohn (2018)
Effects of Non-Steroidal Anti-Inflammatory Drugs on the Gastrointestinal and Cardiovascular System
G Masclee (2016)
10.1007/s10620-010-1560-3
Adverse Effects of Long-Term Proton Pump Inhibitor Therapy
Edward Sheen (2010)
10.4081/REUMATISMO.2011.5
Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections.
Antonella Laria (2011)
O czym warto pamiętać, stosując przewlekle inhibitory pompy protonowej?
Tomasz Wocial (2013)
Original Investigation Proton Pump Inhibitors and Hypomagnesemia in the General Population: A Population-Based Cohort Study
Mark Eijgelsheim (2015)
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