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Role Of Regulatory T Cells In Tubercular Uveitis

Ravi Kumar Sharma, Amod Gupta, Shivali Kamal, Reema Bansal, Nirbhai Singh, Kusum Sharma, Sonia Virk, Naresh Sachdeva
Published 2018 · Medicine
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ABSTRACT Purpose: To study the role of regulatory T cells (Tregs) in patients with tubercular uveitis. Methods: Frequencies of peripheral Tregs, Th1, Th17 cells, and intracellular cytokines were determined in 17 tubercular uveitis patients and 18 disease controls. Function of Tregs, Th1, and Th17 cells was assessed in vitro. Simultaneously, ocular levels of IFN-γ, IL-17A, IL-4, and IL-10 were also measured. Results: Frequencies of peripheral Tregs in tubercular uveitis subjects were significantly lower compared with disease controls. Furthermore, expression of TGF-β and IL-2Rα, but not CTLA4, was reduced in Tregs of the tubercular uveitis group. The tubercular uveitis group demonstrated heightened Th1, Th17 responses following in vitro stimulation with phorbol myristate acetate (PMA)/ionomycin. Interestingly, Treg suppression assay did not show a significant difference between the two groups. Ocular levels of IFN-γ, IL-17A, and IL-10 were also elevated in tubercular uveitis group. Conclusions: Low Treg frequency and hyporesponsive function contribute to proinflammatory responses manifesting at ocular level in tubercular uveitis.
This paper references
Pathogenesis and Pathology of Intraocular Tuberculosis
Soumyava Basu (2015)
CD4+Foxp3+ T-regulatory cells in noninfectious uveitis.
Steven Yeh (2009)
Classification of Intraocular Tuberculosis
Amod Gupta (2015)
New treatments for serpiginous choroiditis.
Esen K Akpek (2003)
Functional Activity of Th-17 Lymphocytes in Pulmonary Tuberculosis
Tatyana Kononova (2014)
The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy
Guo-qiang Wang (2014)
Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease.
J Shimizu (2012)
Immunomodulatory action of mycobacterial secretory proteins.
Vladimir D. Trajkovic (2004)
Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis.
D. Robinson (1994)
Pattern of uveitis in a referral eye clinic in North India.
Amjad Salman (2004)
Comparison of interferon-γ-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infection.
Juthaporn Cowan (2012)
Experimental mouse model of tuberculous uveitis
Sudhanshu Abhishek (2014)
Adalimumab specifically induces CD3+ CD4+ CD25high Foxp3+ CD127− T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis: a non-randomized pilot intervention study
Said Calleja (2012)
Expansion of Pathogen-Specific Mono- and Multifunctional Th1 and Th17 Cells in Multi-Focal Tuberculous Lymphadenitis
Nathella Pavan Kumar (2013)
Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis.
A. A. Abu El-Asrar (2012)
Analysis of Th1, Th17 and regulatory T cells in tuberculosis case contacts.
Rocío Edith García Jacobo (2014)
Aqueous cytokine and chemokine analysis in uveitis associated with tuberculosis
Marcus Ang (2012)
Suppression assays with human T regulatory cells: a technical guide.
A. McMurchy (2012)
Adalimumab specifically induces CD3(+
S Calleja (2012)
Imbalance of Th17 to Th1 cells in Behçet's disease.
J. Kim (2010)
Identification of viral antigens recognized by ocular infiltrating T cells from patients with varicella zoster virus-induced uveitis.
Johannes C M Milikan (2007)
Interleukin 17A as an effective target for anti-inflammatory and antiparasitic treatment of toxoplasmic uveitis.
Arnaud Sauer (2012)
Diminished frequency and function of CD4+CD25high regulatory T cells associated with active uveitis in Vogt-Koyanagi-Harada syndrome.
Lina Chen (2008)
Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease.
Chaokui Wang (2012)
Replication of Mycobacterium tuberculosis in retinal pigment epithelium.
Hossein Nazari (2014)
Characterization of Toxoplasma gondii-specific T cells recovered from vitreous fluid of patients with ocular toxoplasmosis.
Eric J. Feron (2001)
Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack
Y. Nanke (2008)
IL-22-secreting Th22 and IFN-γ-secreting Th17 cells in Behçet's disease
Esin Aktaş Çetin (2014)
Frequency of Regulatory T-Cells in the Peripheral Blood of Patients with Pulmonary Tuberculosis from Shanxi Province, China
Hui Pang (2013)
[The balance of Th1 and Th17 cells in tuberculous pleural effusion].
Ronghui Du (2012)
Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis.
Nancy D Marin (2010)
IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease.
J. O. Jurado (2012)
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
P. A. Darrah (2007)
Treg Lymphocytes in Autoimmune Uveitis
Simona Ruggieri (2012)
Th17 cells in Behçet's disease: a new immunoregulatory axis.
Kamel Hamzaoui (2011)
Degree, duration, and causes of visual loss in uveitis
Omar M. Durrani (2004)
Experimental ocular tuberculosis in guinea pigs.
Narsing A. Rao (2009)
Quantifying cell turnover using CFSE data.
V. V. Ganusov (2005)

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