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Elevated Neuronal Nitric Oxide Synthase Expression During Ageing And Mitochondrial Energy Production
P. Lam, F. Yin, R. Hamilton, A. Boveris, E. Cadenas
Published 2009 · Biology, Medicine
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This study evaluated the effect of ageing on brain mitochondrial function mediated through protein post-translational modifications. Neuronal nitric oxide synthase increased with age and this led to a discreet pattern of nitration of mitochondrial proteins. LC/MS/MS analyses identified the nitrated mitochondrial proteins as succinyl-CoA-transferase and F1-ATPase; the latter was nitrated at Tyr269, suggesting deficient ADP binding to the active site. Activities of succinyl-CoA-transferase, F1-ATPase and cytochrome oxidase decreased with age. The decreased activity of the latter cannot be ascribed to protein modifications and is most likely due to a decreased expression and assembly of complex IV. Mitochondrial protein post-translational modifications were associated with a moderately impaired mitochondrial function, as indicated by the decreased respiratory control ratios as a function of age and by the release of mitochondrial cytochrome c to the cytosol, thus supporting the amplification of apoptotic cascades.
This paper references
Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues.
D. Williamson (1971)
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
J. Beckman (1990)
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
G. Brown (1994)
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
J. Abrahams (1994)
1 – The Physiological and Pathological Chemistry of Nitric Oxide
J. Beckman (1996)
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.
J. Beckman (1996)
The nitric oxide hypothesis of brain aging
S. Mccann (1997)
Cellular sources and steady-state levels of reactive oxygen species
A Boveris (1997)
Spontaneous expression of inducible nitric oxide synthase in the hypothalamus and other brain regions of aging rats.
D. Vernet (1998)
Rapid and irreversible inhibition of creatine kinase by peroxynitrite
E. Konorev (1998)
Nitric oxide in neurodegeneration.
V. Dawson (1998)
Nitric oxide, mitochondria and neurological disease.
S. Heales (1999)
Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage.
F. Schöpfer (2000)
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.
Y. Kashiwaya (2000)
Regulation of Mitochondrial Respiration by Oxygen and Nitric Oxide
A. Boveris (2000)
Astrocyte‐Derived Nitric Oxide Causes Both Reversible and Irreversible Damage to the Neuronal Mitochondrial Respiratory Chain
V. Stewart (2000)
Reactions of peroxynitrite in the mitochondrial matrix.
L. Valdez (2000)
Astrocytederived nitric oxide causes both reversible and irreversible damage to the neuronal mitochondrial respiratory chain
VC Stewart (2000)
Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation.
N. Riobo (2001)
Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space.
D. Han (2001)
Novel effects of nitric oxide.
K. Davis (2001)
Nitric oxide inhibits mitochondrial NADH-ubiquinone reductase activity through the formation of peroxynitrite
NA Riobó (2001)
Cyclic guanosine 5′ monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats
A. Estevez (2002)
The Modulation of Mitochondrial Nitric-oxide Synthase Activity in Rat Brain Development*
N. Riobo (2002)
Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies.
C. Cooper (2003)
Oxidative Damage to Mitochondrial Complex I Due to Peroxynitrite
J. Murray (2003)
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.
K. Tieu (2003)
On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide.
F. Antunes (2004)
Expression of cGMP-dependent protein kinases (I and II) and neuronal nitric oxide synthase in the developing rat cerebellum
Sandra Jurado (2005)
Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex I subunits: implications for Parkinson's disease.
Srinivas Bharath (2005)
Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione.
D. Han (2005)
Expression of cGMPdependent protein kinases (I and II) and neuronal nitric oxide synthase in the developing rat cerebellum
S Jurado (2005)
Nitric oxide, cell bioenergetics and neurodegeneration
S. Moncada (2006)
Regulation of apoptosis by protein S-nitrosylation
J. Mannick (2006)
Mitochondrial metabolic states and membrane potential modulate mtNOS activity.
L. Valdez (2006)
Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide.
B. Derakhshan (2007)
Nitration of tryptophan 372 in succinyl-CoA:3-ketoacid CoA transferase during aging in rat heart mitochondria.
I. Rebrin (2007)
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
V. Calabrese (2007)
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Age-related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses: Insights from animal models of aging.
A. Yabluchanskiy (2020)
Neuroprotective mechanisms of Ginkgo biloba against oxidative stress
H. Cheung (2020)
Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation
Mattéa J. Finelli (2020)
Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability?
B. Ibrahim (2019)
iNOS as a metabolic enzyme under stress conditions.
S. Anavi (2019)
Mitochondrial Dysfunction in Aging and Neurodegeneration
Vaibhav Walia (2019)
Brain ageing and neurodegenerative disease: The role of cellular waste management.
S. Daniele (2018)
Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus
C. Lourenço (2018)
p66Shc Inactivation Modifies RNS Production, Regulates Sirt3 Activity, and Improves Mitochondrial Homeostasis, Delaying the Aging Process in Mouse Brain
H. Pérez (2018)
Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson's Disease.
Gorelenkova MillerOlga (2018)
Cyclophilin D Promotes Brain Mitochondrial F1FO ATP Synthase Dysfunction in Aging Mice.
Esha Gauba (2017)
Characterization of novel mitochondrial modulators for the development of neuroprotective strategies
Imane Lejri (2016)
Effects of environmental enrichment in aged mice on anxiety-like behaviors and neuronal nitric oxide synthase expression in the brain.
Yuki Tomiga (2016)
Energy metabolism and inflammation in brain aging and Alzheimer's disease.
F. Yin (2016)
Mitochondrial function in ageing: coordination with signalling and transcriptional pathways
F. Yin (2016)
The Effect of Aging on Mitochondrial Complex I and the Extent of Oxidative Stress in the Rat Brain Cortex
Z. Tatarková (2016)
Aged neuronal nitric oxide knockout mice show preserved olfactory learning in both social recognition and odor-conditioning tasks
B. M. James (2015)
Energy-Redox Axis in Mitochondria: Interconnection of Energy-Transducing Capacity and Redox Status
Z. Liu (2015)
The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity
Fei Yin (2015)
Artemisinin and Nitric Oxide: Mechanisms and Implications in Disease and Health
Q. Zeng (2015)
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration.
F. Yin (2014)
Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease
J. M. V. Kampen (2014)
Nicotinamide Nucleotide Transhydrogenase (Nnt) Links the Substrate Requirement in Brain Mitochondria for Hydrogen Peroxide Removal to the Thioredoxin/Peroxiredoxin (Trx/Prx) System*
Pamela Lopert (2014)
Trx / Prx ) System Removal to the Thioredoxin / Peroxiredoxin Brain Mitochondria for Hydrogen Peroxide ( Nnt ) Links the Substrate Requirement in Nicotinamide Nucleotide Transhydrogenase
Pamela Lopert (2014)
S-nitrosylation-impaired autophagy: An alternative mechanism underlying aging?
Q. Zeng (2013)
Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling.
F. Yin (2013)
Lipoic acid restores age‐associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway
Tianyi Jiang (2013)
Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
Philip Y. Lam (2012)
Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells.
F. Yin (2012)
Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation.
Elizabeth A. Sabens Liedhegner (2012)
Endotoxemia impairs heart mitochondrial function by decreasing electron transfer, ATP synthesis and ATP content without affecting membrane potential
V. Vanasco (2012)
Models of Mitochondrial Oxidative Stress
E. Cadenas (2011)See more