Online citations, reference lists, and bibliographies.
← Back to Search

Enhanced Tumor Targeting Effects Of A Novel Paclitaxel-loaded Polymer: PEG–PCCL-modified Magnetic Iron Oxide Nanoparticles

X. Li, Yuan Yang, Y. Jia, Xuan Pu, T. Yang, Yicheng Wang, Xuefei Ma, Qi Chen, Mengwen Sun, Dapeng Wei, Y. Kuang, Y. Li, Yu Liu
Published 2017 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Background: Multifunctional magnetic nanoparticles (MNP) have been newly developed for tumor-targeted drug carriers. To address challenges including biocompatibility, stability, nontoxicity, and targeting efficiency, here we report the novel drug deliverer poly(ethylene glycol) carboxyl–poly(ɛ-caprolactone) modified MNP (PEG–PCCL-MNP) suitable for magnetic targeting based on our previous studies. Methods: Their in vitro characterization and cytotoxicity assessments, in vivo cytotoxicity assessments, and antitumor efficacy study were elaborately investigated. Results: The size of PEG–PCCL-MNP was 79.6 ± 0.945 nm. PEG–PCCL-MNP showed little in vitro or in vivo cytotoxicity and good biocompatibility, as well as effective tumor-specific cell targeting for drug delivery with the presence of external magnetic field. Discussion: PEG–PCCL-MNP is a potential candidate of biocompatible and tumor-specific targeting drug vehicle for hydrophobic drugs.
This paper references
10.1021/nn900330m
Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.
E. K. U. Larsen (2009)
10.3109/10717544.2015.1035466
Prodrug-based nano-drug delivery system for co-encapsulate paclitaxel and carboplatin for lung cancer treatment
Wen Zhang (2016)
10.1016/j.ejpb.2008.05.019
Encapsulation of mitoxantrone into pegylated SUVs enhances its antineoplastic efficacy.
C. Li (2008)
Nuclear imaging in cancer theranostics.
S. Del Vecchio (2007)
10.3109/10717544.2014.903535
Thermosensitive PEG–PCL–PEG (PECE) hydrogel as an in situ gelling system for ocular drug delivery of diclofenac sodium
Z. Luo (2016)
10.1016/j.jconrel.2008.09.086
Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation.
F. Danhier (2009)
10.1021/tx500115p
Cytotoxicity of calcium rectorite micro/nanoparticles before and after organic modification.
Yin Liu (2014)
10.1007/s10495-010-0485-9
Microenvironmental influences of apoptosis in vivo and in vitro
C. Gregory (2010)
10.1021/nn100190v
PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo.
C. Sun (2010)
10.1016/j.biomaterials.2011.05.024
Magnetic brain tumor targeting and biodistribution of long-circulating PEG-modified, cross-linked starch-coated iron oxide nanoparticles.
Adam J. Cole (2011)
10.1016/S0014-3057(96)00091-2
Polydispersity index and molecular weight distributions of polymers
M. Rogošić (1996)
10.1021/mp800032f
Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution.
M. Dobrovolskaia (2008)
10.2147/IJN.S45062
Preparation and characterization of monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) micelles for the solubilization and in vivo delivery of luteolin
Jin-Feng Qiu (2013)
10.1016/j.addr.2010.07.009
Nanoparticle-based theranostic agents.
J. Xie (2010)
10.1016/j.addr.2011.09.001
Toxicology of nanoparticles.
A. Elsaesser (2012)
10.1155/2012/920764
Application of Ferriferous Oxide Modified by Chitosan in Gene Delivery
Yu Chun Kuang (2012)
10.2147/IJN.S45313
Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
H. Rahman (2013)
10.1021/nl0805615
Method for analysis of nanoparticle hemolytic properties in vitro.
M. Dobrovolskaia (2008)
10.1016/j.jconrel.2011.04.017
Biophysical characterization of hyper-branched polyethylenimine-graft-polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery.
Y. Liu (2011)
10.3109/10717544.2013.834418
Tumor targeting effects of a novel modified paclitaxel-loaded discoidal mimic high density lipoproteins
J. Wang (2013)
10.1055/S-0038-1653747
The complexity of the phospholipid binding protein Annexin V.
W. V. van Heerde (1995)
10.1016/S0076-6879(00)22004-1
Detection of apoptosis by annexin V labeling.
E. Bossy-Wetzel (2000)
10.1016/j.jconrel.2010.05.022
A novel lipoprotein-mimic nanocarrier composed of the modified protein and lipid for tumor cell targeting delivery.
Ying Cao Xu (2010)
10.1016/j.tibtech.2011.03.001
Cancer theranostics: the rise of targeted magnetic nanoparticles.
Adam J. Cole (2011)
10.1039/c0nr00758g
Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo.
M. Gou (2011)
10.2147/IJN.S31162
Nanocalcium-deficient hydroxyapatite–poly (ɛ-caprolactone)–polyethylene glycol–poly (ɛ-caprolactone) composite scaffolds
Z. Wang (2012)
10.1148/RADIOLOGY.214.2.R00FE19568
Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model.
A. Moore (2000)



This paper is referenced by
10.3390/antibiotics7020046
Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity
L. S. Arias (2018)
10.2174/1389200220666191007154017
Oral Delivery of Anticancer Agents using Nanoparticulate Drug Delivery System.
Prateek Mathur (2019)
10.1007/978-981-15-5386-8
Nanotechnology in Regenerative Medicine and Drug Delivery Therapy
H. Xu (2020)
10.1007/978-3-030-41838-0_6
An Overview of Paclitaxel Delivery Systems
Anirudh Prabakaran (2020)
10.1016/j.jinorgbio.2020.111117
Metal-derived nanoparticles in tumor theranostics: Potential and limitations.
Oleg A Kuchur (2020)
10.1080/03639045.2019.1640721
Doxorubicin derivative loaded acetal-PEG-PCCL micelles for overcoming multidrug resistance in MCF-7/ADR cells
Xincheng Zhong (2019)
10.1088/1361-6528/aaf9ec
Physiochemical properties and paclitaxel release behaviors of dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites.
Yu Liu (2019)
10.1002/PPSC.201900112
Clustering of Iron Oxide Nanoparticles with Amphiphilic Invertible Polymer Enhances Uptake and Release of Drugs and MRI Properties
Paige M. Price (2019)
10.1007/978-3-030-10614-0_38-1
Iron Oxide-Based Polymeric Magnetic Nanoparticles for Drug and Gene Delivery: In Vitro and In Vivo Applications in Cancer
S. Yalçın (2019)
10.2147/IJN.S184723
A review of small molecules and drug delivery applications using gold and iron nanoparticles
Hossein Jahangirian (2019)
10.1016/j.polymdegradstab.2020.109191
Degradation of methoxy-poly (ethylene glycol)-block-poly(α-carboxyl-ε-caprolactone)/magnetite nanocomposites in vitro polymer degradation and stability
Y. Li (2020)
Semantic Scholar Logo Some data provided by SemanticScholar