Online citations, reference lists, and bibliographies.

TWO LIQUID CHROMATOGRAPHIC METHODS FOR THE SIMULTANEOUS DETERMINATION OF IBUPROFEN AND METHOCARBAMOL OR CHLORZOXAZONE IN THE PRESENCE OF THEIR DEGRADATION PRODUCTS

Ehab Farouk Elkady, Marwa A Fouad
Published 2012 · Chemistry
Cite This
Download PDF
Analyze on Scholarcy
Share
Two RP-LC methods have been developed for the simultaneous determination of ibuprofen (IBU) and two skeletal muscle relaxants, namely methocarbamol (MET) or chlorzoxazone (CHZ), in the presence of their degradation products. In the first method, the simultaneous determination of IBU and MET in the presence of guaifenesin (GUF), a degradation product of MET, was developed. Chromatographic separation was achieved on an Inertsil CN-3 column (250 mm × 4.6 mm, 5 µm). Gradient elution based on 0.5% aqueous phosphoric acid (pH 2.8) - acetonitrile at a flow rate of 1 mL min−1 was applied with UV detection at 229 nm for IBU and 274 nm for MET and GUF. Linearity, accuracy, and precision were found to be acceptable over the concentration ranges of 5–160 µg mL−1 for IBU and 2.5–160 µg mL−1 for MET and GUF. In the second method, the simultaneous determination of IBU and CHZ in the presence of CHZ degradation product, 2-amino-4-chlorophenol (CDE), was developed. In this method, chromatographic separation was achieved on Reprosil-Pur C8 (250 mm × 4.6 mm, 5 µm). A gradient mobile phase system consisting of acetonitrile and 0.2% aqueous triethylamine (pH 5.1) at a flow rate of 1 mL min−1 was applied with UV detection at 229 nm for the three compounds. Linearity, accuracy, and precision were found to be acceptable over the concentration ranges of 2.5–250 µg mL−1 IBU and CHZ, and 2.5–150 µg mL−1 CDE. The optimized methods were validated and proved to be specific, robust, and accurate for the quality control of the cited drugs in synthetic mixtures and pharmaceutical preparations.
This paper references
Spectrophotometric Determination of Two Skeletal Muscle Relaxants in Mixtures with Other Drugs
S. T. Hassib (2006)
10.1016/0003-2670(95)00264-Z
Determination of benzhexol hydrochloride and ethambutol hydrochloride tablets by liquid chromatography
C Ma (1995)
10.1016/S0039-9140(98)00043-5
Reversed-phase HPLC method for the estimation of acetaminophen, ibuprofen and chlorzoxazone in formulations.
S. Ravisankar (1998)
A Simple and Rapid High-Performance Liquid Chromatographic Method for the Determination of Bisoprolol Fumarate and Hydrochlorothiazide in a Tablet
S. Shaikh (2008)
10.1093/CHROMSCI/48.10.825
TLC chromatographic-densitometric assay of ibuprofen and its impurities.
Małgorzata Starek (2010)
Pospí s silová, M. Determination of Ibuprofen and Flurbiprofen in Pharmaceuticals by Capillary Zone Electrophoresis
R Hamoudová (2006)
The European Agency for the Evaluation of Medical Products. ICH Topic Q2B Note for Guidance on Validation of Analytical Procedures: Methodology CPMP=ICH=281=95, ICH-Technical Coordination-R
(1996)
10.1016/S0378-4347(96)00326-X
High-performance thin-layer chromatographic determination of ibuprofen in plasma.
Thierry Save (1997)
10.1134/S1061934810070142
Experimental design of reversed-phase high performance liquid chromatographic conditions for simultaneous determination of ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate, and nipagen
Bürge Aşçı (2010)
Simultaneous Estimation of Paracetamol, Methocarbamol and Ibuprofen by a Reversed-Phase HPLC Method
M. Vasudevan (2000)
10.1016/S1570-0232(02)00543-3
Validation of a liquid chromatographic method for the determination of ibuprofen in human plasma.
Henry C. Farrar (2002)
10.1016/S0731-7085(03)00578-8
Simultaneous spectrophotometric determination of pseudoephedrine hydrochloride and ibuprofen in a pharmaceutical preparation using ratio spectra derivative spectrophotometry and multivariate calibration techniques.
Ismail Murat Palabiyik (2004)
Simultaneous Spectrophotometric Determination of Paracetamol, Ibuprofen and Caffeine in Pharmaceuticals by Chemometric Methods. Spectrochim
M. R. Khoshayand (2008)
10.1016/S0014-827X(02)00026-5
Kinetic study of alkaline induced hydrolysis of the skeletal muscle relaxant chlorzoxazone using ratio spectra first derivative spectrophotometry.
M M Ellaithy (2003)
10.1016/j.jpba.2006.03.024
Determination of ibuprofen and flurbiprofen in pharmaceuticals by capillary zone electrophoresis.
R. Hamoudová (2006)
10.1016/0003-2670(91)90042-4
Analytical profiles of drug substances
K. Florey (1972)
SPECTROPHOTOMETRIC DETERMINATION OF 2- AMINO- 4- CHLOROPHENOL AS A POTENTIAL IMPURITY IN CHLORZOXAZONE BULK DRUG
Fathallah F Belal (2011)
10.1016/j.talanta.2010.07.024
Simultaneous determination of diclofenac potassium and methocarbamol in ternary mixture with guaifenesin by reversed phase liquid chromatography.
Ehab Farouk Elkady (2010)
10.1016/j.jchromb.2003.08.031
Enantioselective determination of ibuprofen in plasma by high-performance liquid chromatography-electrospray mass spectrometry.
Pierina Sueli Bonato (2003)
10.1007/s11419-010-0096-8
Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column
Xiao-Pen Lee (2010)
Second Derivative Synchronous Fluorescence Spectroscopy for the Simultaneous Determination of Chlorzoxazone and Ibuprofen in Pharmaceutical Preparations and Biological Fluids
N. El-enany (2009)
Determination of Ibuprofen and Sodium Phenobarbital in Compound Ibuprofen for Suspension by HPLC
C. Miao (2009)
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF CHLORZOXAZONE ANDIBUPROFEN, SIMULTANEOUSLY FROM PHARMACEUTICAL PREPARATION
S. S. Zarapkar (1996)
10.1016/S0731-7085(00)00584-7
Spectrofluorometric determination of ibuprofen in pharmaceutical formulations.
Patricia C. Damiani (2001)
Martindale: The Complete Drug Reference
Sean C. Sweetman (1999)
10.1016/J.SAA.2007.07.033
Simultaneous spectrophotometric determination of paracetamol, ibuprofen and caffeine in pharmaceuticals by chemometric methods.
M R Khoshayand (2008)
High-Performance Liquid-Chromatographic Determination of Chlorzoxazone and Ibuprofen, Simultaneously from Pharmaceutical Preparations
S. S. Zarapkar (1996)
10.1002/jps.2600830411
Methocarbamol degradation in aqueous solution.
Nicole Pouli (1994)
10.1016/j.jpba.2008.08.009
A simple and rapid high-performance liquid chromatographic method for the determination of bisoprolol fumarate and hydrochlorothiazide in a tablet dosage form.
Saleem Z. Shaikh (2008)
10.1016/J.ARABJC.2010.06.044
Simultaneous determination of ibuprofen and paracetamol using derivatives of the ratio spectra method
Yousry Moustafa Issa (2011)
10.1016/J.JPBA.2007.11.006
Simultaneous determination of metoprolol succinate and amlodipine besylate in pharmaceutical dosage form by HPLC.
Vaijanath G. Dongre (2008)
10.1016/j.jpba.2010.03.024
Quantitative determination of peptide drug in human plasma samples at low pg/ml levels using coupled column liquid chromatography-tandem mass spectrometry.
Ulf Lövgren (2010)
The Complete Drug Reference, 34th ed
Sweetman (2005)
THREE SIMPLE SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF IBUPROFEN AND CHLORZOXAZONE IN TABLETS
S. Ravi Sankar (1997)
Simultaneous Spectrophotometric Determination of Ibuprofen and Chlorzoxazone in Tablet Formulation
L.N.M. Kotak (1998)
Spectrophotometric Methods for Simultaneous Determination of Ibuprofen and Methocarbamol
N. K. Ramadan (2006)
Simultaneous Spectrophotometric Determination of Ibuprofen and Chlorzoxazone in Tablet Formulation. Eastern Pharm
L N M Kotak (1998)
UPLC=MS=MS Determination of Prednisone Acetate, Dexamethasone Acetate, Diclofenac Sodium and Ibuprofen Mixed in Antirheumatic Traditional Chinese Medicine. Chin
F Zhao (2010)
イブプロフェンとその不純物のTLC(薄層クロマトグラフィー)‐デンシトメトリー分析
Starek Malgorzata (2010)
10.1016/0731-7085(95)01306-6
Determination of ibuprofen in erythrocytes and plasma by high performance liquid chromatography.
Jaroslav Sochor (1995)
UPLC/MS/MS determination of prednisone acetate,dexamethasone acetate,diclofenac sodium and ibuprofen mixed in antirheumatic traditional Chinese medicine
Wang Sheng-ying (2010)
Simultaneous spectrophotometric estimation of ibuprofen and methocarbamol in tablet dosage form
T R S Satheeshmanikandan (2004)
The United States Pharmacopoeia (USP 30), National Formulary (NF 25)
(2007)
Comprar Martindale the complete reference 36th Ed | Sean Sweetman | 9780853698401 | Pharmaceutical Press
Sean C. Sweetman (2010)
10.1016/S0039-9140(03)00095-X
Spectrofluorimetric study of the beta-cyclodextrin-ibuprofen complex and determination of ibuprofen in pharmaceutical preparations and serum.
L. A. Hergert (2003)
10.1016/j.jchromb.2004.11.060
New approaches with two cyano columns to the separation of acetaminophen, phenylephrine, chlorpheniramine and related compounds.
B. Olmo (2005)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar