Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Antigen-Induced Death Of T-Lymphocytes
D. Kabelitz, O. Janssen
Published 1998 · Biology
Save to my Library
Download PDFAnalyze on Scholarcy
Resting mature T-lymphocytes are activated when they are triggered via their antigen-specific T-cell receptor (TCR) molecule or the associated CD3 antigen. In contrast, preactivated T-cells can undergo activation-induced cell death (AICD) in response to the same signals. Stimulation of activated T-cells upregulates the expression of the Fas-ligand, and the interaction of Fas-ligand with the corresponding Fas receptor triggers an apoptosis program that culminates in cellular suicide usually associated with the fragmentation of DNA into oligonucleosomal bands. Molecular evidence indicates that proteases related to interleukin-1-β converting enzyme play an essential role in the execution of cell death. AICD of mature T-lymphocytes can be efficiently triggered by monoclonal antibodies against the CD3/TCR complex, or by superantigens such as bacterial enterotoxins. Although it is more difficult to induce AICD by conventional peptide antigens, it is now clear that antigen-induced AICD is a powerful means of eli...
This paper references
Activation and re-activation potential of T cells responding to staphylococcal enterotoxin B.
M. E. Hamel (1995)
Identification and characterization of a new member of the TNF family that induces apoptosis.
S. Wiley (1995)
Induction of unresponsiveness to the superantigen staphylococcal enterotoxin B: cyclosporin A resistant split unresponsiveness unfolds in vivo without preceding clonal expansion.
K. Heeg (1993)
Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.
P. Bossù (1993)
RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
B. Stanger (1995)
FK506 augments activation-induced programmed cell death of T lymphocytes in vivo.
K. Migita (1995)
In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.
Y. Shi (1991)
Fas ligand mediates activation-induced cell death in human T lymphocytes
M. Alderson (1995)
APO-1 (CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines.
M. Peter (1995)
Immunosuppression by OKT3--induction of programmed cell death (apoptosis) as a possible mechanism of action.
O. Janssen (1992)
Induction of cell death via Fas (CD95, Apo-1) may be associated with but is not dependent on Fas-induced tyrosine phosphorylation.
O. Janssen (1996)
Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression.
J. Critchfield (1995)
Peripheral deletion of mature CD8+ antigen-specific T cells after in vivo exposure to male antigen.
L. Zhang (1992)
A Kinin in Apple Fruitlets
P. Goldacre (1959)
Antigen‐induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*
E. Jenkinson (1989)
Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones
S. Meuer (1983)
Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion
X. Zhang (1995)
Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
G. Schönrich (1991)
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
S. Yonehara (1989)
IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.
M. Radrizzani (1995)
lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis
M. Lenardo (1991)
Life and death of a superantigen-reactive human CD4+ T cell clone: staphylococcal enterotoxins induce death by apoptosis but simultaneously trigger a proliferative response in the presence of HLA-DR+ antigen-presenting cells.
D. Kabelitz (1992)
Programmed cell death of T cells signaled by the T cell receptor and the alpha 3 domain of class I MHC.
S. Sambhara (1991)
CD3‐mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin‐1, interleukin‐2, interferon‐γ and accessory cells
H. Groux (1993)
Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand
T. Renno (1996)
Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals.
C. Pelfrey (1995)
Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes.
J. Dutz (1992)
Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice
C. Sidman (1992)
Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases
S. Mariani (1995)
A role for CD95 ligand in preventing graft rejection
D. Bellgrau (1995)
Dna fragmentation and cell death mediated by t cell antigen receptor/cd3 complex on a leukemia t cell line*
S. Takahashi (1989)
Soluble MHC II-peptide complexes induce antigen-specific apoptosis in T cells.
B. Nag (1996)
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
M. Cifone (1994)
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
J. Kerr (1972)
Influenza peptide-induced self-lysis and down-regulation of cloned cytotoxic T cells.
R. M. Pemberton (1990)
Development and selection of T cells: facts and puzzles.
P. Kisielow (1995)
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.
S. Meuer (1984)
Sensitivity of T cells to anti‐CD3‐stimulated suicide is independent of functional phenotype
J. H. Russell (1992)
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
D. Nicholson (1995)
Antigen‐Induced Death of Mature T Lymphocytes: Analysis by Flow Cytometry
D. Kabelitz (1994)
The pharmacology of T cell apoptosis.
G. Kroemer (1995)
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
T. Brunner (1995)
The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.
H. Sytwu (1996)
Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.
S. Wesselborg (1993)
Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.
T. Stalder (1994)
Apoptotic elimination of Vβ8.2+ cells from the central nervous system during recovery from experimental autoimmune encephalomyelitis induced by the passive transfer of Vβ8.2+ encephalitogenic T cells
Z. Tabi (1994)
Anti‐CD3‐induced cell death in T cell hybridomas: mitochondrial failure and DNA fragmentation are distinct events
S. Vukmanović (1991)
Apoptosis of αβ T Lymphocytes in the Nervous System in Experimental Autoimmune Encephalomyelitis: Its Possible Implications for Recovery and Acquired Tolerance
M. Pender (1992)
Antigen as a positive and negative regulator of proliferation in cytotoxic lymphocytes. A model for the differential regulation of proliferation and lytic activity.
J. H. Russell (1988)
Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity
E. Rouvier (1993)
Growth inhibition of human T cells by antibodies recognizing the T cell antigen receptor complex.
J. Breitmeyer (1987)
T cell deletion follows chronic antigen specific T cell activation in vivo.
C. Mamalaki (1993)
Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis
S. Strand (1998)
Naive murine neonatal T cells undergo apoptosis in response to primary stimulation.
B. Adkins (1996)
Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes
N. Zavazava (1996)
Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes.
P. Walden (1990)
Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape
M. Hahne (1996)
Fas and Fas ligand: lpr and gld mutations.
S. Nagata (1995)
Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.
N. Damle (1993)
Antigen-induced death of alloreactive human T-lymphocytes occurs in the absence of low molecular weight DNA fragmentation.
T. Pohl (1995)
Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.
L. Radvanyi (1993)
Fas‐induced programmed cell death is mediated by a Ras‐regulated O2− synthesis
E. Gulbins (1996)
Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice.
D. Scott (1993)
Fas (CD95)-independent regulation of immune responses by antigen-specific CD4-CD8+ T cells.
S. J. Teh (1996)
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
A. Wyllie (1980)
Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.
F. Kischkel (1995)
The Fas death factor
S. Nagata (1995)
Receptor-stimulated death pathway is opened by antigen in mature T cells.
J. H. Russell (1991)
Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules.
M. Merćep (1988)
Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen
M. Newell (1990)
Induction of donor-specific tolerance to cardiac but not skin or renal allografts by intrathymic injection of splenocyte alloantigen.
Y. Nakafusa (1993)
Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes
S. Wesselborg (1993)
Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines
S. Baschieri (1993)
Apoptosis in Immunology
G. Kroemer (1995)
Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation.
G. Cohen (1992)
Cell nucleus and DNA fragmentation are not required for apoptosis
K. Schulze-Osthoff (1994)
Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.
C. Eischen (1994)
Clonal expansion precedes anergy and death of Vβ8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo
H. Macdonald (1991)
Virus-induced polyclonal T cell activation is followed by apoptosis: partitioning of CD8+ T cells based on alpha 4 integrin expression.
J. Christensen (1996)
Induction of apoptosis in mature T cells by tumour necrosis factor
Lixin Zheng (1995)
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis
Q. Tian (1995)
Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus
H. Acha-Orbea (1991)
Inhibition of T cell proliferation specific for acetylcholine receptor epitopes related to myasthenia gravis with antibody to T cell receptor or with competitive synthetic polymers.
S. Brocke (1990)
Thymic and peripheral apoptosis of antigen‐specific T cells might cooperate in establishing self tolerance
L. D'Adamio (1993)
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen.
N. Itoh (1993)
T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells.
O. Janssen (1991)
Peripheral tolerance through clonal deletion of mature CD4-CD8+ T cells.
D. Carlow (1992)
Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
S. Webb (1990)
Apoptosis in AIDS.
M. Gougeon (1993)
Induction of sensitivity to activation‐induced death in primary CD4+ cells: A role for interleukin‐2 in the negative regulation of responses by mature CD4+ T cells
R. Wang (1996)
Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice
Y. Kawabe (1990)
The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis
M. Salmon (1994)
T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides
D. Kyburz (1993)
Peptide epitope induced apoptosis of human cytotoxic T lymphocytes. Implications for peripheral T cell deletion and peptide vaccination.
A. Suhrbier (1993)
FAP-1: a protein tyrosine phosphatase that associates with Fas.
T. Sato (1995)
THE STAPHYLOCOCCAL ENTEROTOXINS AND THEIR RELATIVES
P. Marrack (1990)
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death
L. Casciola-Rosen (1996)
Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.
D. Ucker (1989)
Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.
S. Ju (1994)
CTLA4 mediates antigen-specific apoptosis of human T cells.
J. Gribben (1995)
The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance.
L. van Parijs (1996)
Multiple levels of peripheral tolerance.
B. Arnold (1993)
Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle
S. Boehme (1993)
Agents that mimic antigen receptor signaling inhibit proliferation of cloned murine T lymphocytes induced by IL-2.
G. Nau (1988)
Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model
R. Baccala (1993)
Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals.
P. Katsikis (1996)
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
M. Boldin (1996)
Antigen-specific down-regulation of myelin basic protein-reactive T cells during spontaneous recovery from experimental autoimmune encephalomyelitis: further evidence of apoptotic deletion of autoreactive T cells in the central nervous system.
Z. Tabi (1995)
Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo.
R. Mogil (1995)
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
G. Williams (1990)
CD95 ligand in graft rejection
H. Yagita (1996)
Peripheral clonal deletion of superantigen‐reactive T cells is enhanced by cortisone
A. R. Lussow (1993)
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
J. Savill (1990)
Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.
D. McConkey (1989)
CD2-induced apoptosis in activated human peripheral T cells: a Fas-independent pathway that requires early protein tyrosine phosphorylation.
B. Mollereau (1996)
Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis
N. Banda (1992)
Surface T cell Fas receptor/CD95 regulation, in vivo activation, and apoptosis. Activation-induced death can occur without Fas receptor.
C. Tucek-Szabo (1996)
Programmed cell death and AIDS pathogenesis: significance and potential mechanisms.
J. C. Ameisen (1995)
Peripheral deletion of antigen-reactive T cells in oral tolerance
Y. Chen (1995)
Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus
G. Waanders (1993)
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
T. Fernandes-Alnemri (1994)
Complex complexes: signaling at the TCR.
R. Wange (1996)
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
A. Chinnaiyan (1995)
Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin‐2 pathway
José Angel Gonzalo (1992)
Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL
M. Alexander-Miller (1996)
Effects of antigen presentation on superantigen‐induced apoptosis mediated by Fas/Fas ligand interactions in human T cells
M. Boshell (1996)
Staphylococcal Enterotoxin B Promotes Deletion and Functional Inactivation of CD4Vβ8‐Positive Cells in the Absence of CD8 T Cells
O. Williams (1993)
Antigen-induced programmed T cell death as a new approach to immune therapy.
J. Critchfield (1995)
The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.
J. Drappa (1993)
Downregulation of T cell responses by antibodies to the T cell receptor
S. Webb (1987)
Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance
Y. Liu (1990)
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
C. A. Smith (1989)
Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes.
D. Kabelitz (1993)
Activation with superantigens induces programmed death in antigen‐primed CD4+ class II+ major histocompatibility complex T lymphocytes via a CD11a/CD18‐dependent mechanism
N. Damle (1993)
The fate of adoptively transferred antigen‐specific T cells in vivo
L. Zhang (1996)
Deletion of donor-reactive T lymphocytes in adult mice after intrathymic inoculation with lymphoid cells.
J. Markmann (1993)
Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?
S. Strand (1996)
Activation interferes with the APO-1 pathway in mature human T cells.
C. Klas (1993)
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
T. Suda (1993)
THE ASSESSMENT OF TRANSPLANTATION TOLERANCE INDUCED BY ANTI‐CD4 MONOCLONAL ANTIBODY IN THE MURINE MODEL1
T. Pearson (1993)
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
J. Dhein (1995)
High‐Dose Soluble Antigen: Peripheral T‐Cell Proliferation or Apoptosis
R. Liblau (1994)
Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway.
Hong Duck Um (1996)
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
M. Muzio (1996)
T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis.
J. Critchfield (1994)
CD4+CD8+ thymocytes are susceptible to DNA fragmentation induced by phorbol ester, calcium ionophore and anti‐CD3 antibody
T. Tadakuma (1990)
Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.
R. O’Hehir (1990)
In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B
B. Rellahan (1990)
The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice.
G. Singer (1994)
Collagen-induced arthritis in rats: antigen-specific suppression of arthritis and immunity by intravenously injected native type II collagen.
M. A. Cremer (1983)
Selective induction of autocytotoxic activity through the CD3 molecule
A. Bensussan (1990)
Involvement of LFA‐1/ICAM‐2 adhesive interactions and PKC in activation‐induced cell death following SEB rechallenge
E. Z. Tchilian (1996)
Antigen-induced suppression of the proliferative response of T cell clones.
G. Suzuki (1988)
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
D. Kaufman (1993)
T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas.
C. Odaka (1990)
Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody.
G. Nau (1987)
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway.
E. Gulbins (1995)
Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals
H. Groux (1992)
Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis
B. Combadiere (1996)
Fas modulation of apoptosis during negative selection of thymocytes.
J. Castro (1996)
T cell-T cell killing is induced by specific epitopes: evidence for an apoptotic mechanism
D. Moss (1991)
Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.
J. H. Russell (1993)
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
S. Ju (1995)
Programmed cell death induced by ceramide.
L. Obeid (1993)
Prolonged survival of rat orthotopic liver allografts after intrathymic inoculation of donor-strain cells.
L. Campos (1993)
Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli
A. Sarin (1996)
Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
Y. Shi (1989)
Synergy between T cell Receptor and Fas (CD95/APO-1) signaling in mouse thymocyte death.
G. H. Fisher (1996)
CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance.
T. Griffith (1996)
Definition and incidence of apoptosis : A historical perspective
J. F. R. Kerr (1991)
Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B
Y. Kawabe (1991)
The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes.
S. Mccarthy (1992)
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
N. Itoh (1991)
CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.
L. Radvanyi (1996)
CD4+8− help prevents rapid deletion of CD8+ cells after a transient response to antigen
J. Kirberg (1993)
Noncytotoxic human CD4+ T-cell clones presenting and simultaneously responding to an antigen die of apoptosis.
F. Bettens (1995)
Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation.
Y. Shi (1990)
Peripheral tolerance in T cell receptor‐transgenic mice: Evidence for T cell anergy
D. Falb (1996)
Deletion of CD4+ T cells and thymocytes by apoptosis in mouse mammary tumor virus (C4)‐infected Vβ2 transgenic mice
H. Wang (1994)
Apoptosis in the pathogenesis and treatment of disease
C. Thompson (1995)
This paper is referenced by
Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction
R. Shen (2002)
Apoptosis, graft rejection, and transplantation tolerance.
D. Kabelitz (1998)