← Back to Search
Overcoming The Stability, Toxicity, And Biodegradation Challenges Of Tumor Stimuli-responsive Inorganic Nanoparticles For Delivery Of Cancer Therapeutics
J. L. Paris, A. Baeza, M. Vallet-Regí
Published 2019 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
ABSTRACT Introduction: Stimuli-responsive nanomaterials for cancer therapy have attracted much interest recently due to their potential for improving the current standard of care. Different types of inorganic nanoparticles are widely employed for the development of these strategies, but in some cases safety concerns hinder their clinical translation. This review aims to provide an overview of the challenges that inorganic nanoparticles face regarding their stability, toxicity, and biodegradability, as well as the strategies that have been proposed to overcome them. Areas covered: The available information about the in vitro and in vivo biocompatibility, as well as the biodegradability of the following nanoparticles, is presented and discussed: superparamagnetic iron oxide nanoparticles, gold nanoparticles, graphene and mesoporous nanoparticles made of silicon or silicon oxide. The toxicology of inorganic nanoparticles is greatly affected by many physicochemical parameters, and their surface modification emerges as the main intervention to improve their biocompatibility and tailor their performance for specific biomedical applications. Expert opinion: Even though many different studies have been performed regarding the biological behavior of inorganic nanoparticles, long-term in vivo data is still scarce, limiting our capacity to evaluate the proposed nanomaterials for clinical use. The role of biodegradability in different therapeutic contexts is also discussed.
This paper references
Toxicity of silica nanoparticles depends on size, dose, and cell type.
I. Kim (2015)
Graphene-based nanoplatelets: a new risk to the respiratory system as a consequence of their unusual aerodynamic properties.
Anja Schinwald (2012)
Slight temperature changes affect protein affinity and cellular uptake/toxicity of nanoparticles.
M. Mahmoudi (2013)
Gold Nanorods: Electrochemical Synthesis and Optical Properties
Y. Yu (1997)
The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo.
Xinglu Huang (2011)
Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration
Xiaoyong Zhang (2011)
Magnetic nanoparticles: material engineering and emerging applications in lithography and biomedicine
Y. Bao (2015)
Environment-Friendly Method To Produce Graphene That Employs Vitamin C and Amino Acid
J. Gao (2010)
In vitro and in vivo behaviors of dextran functionalized graphene
S. Zhang (2011)
Molecular Scaffolds as Double-Targeting Agents For the Diagnosis and Treatment of Neuroblastoma.
Gonzalo Villaverde (2019)
TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine
Q. Pankhurst (2003)
Targeted Chemo‐Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment
Gonzalo Villaverde (2018)
Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells.
Yongbin Zhang (2010)
• Review which describes the use of GNP in hyperthermia treatment of tumours
Seed-Mediated Synthesis of Gold Nanorods: Role of the Size and Nature of the Seed
Anand Gole and (2004)
Surface charge of gold nanoparticles mediates mechanism of toxicity.
Nicole Schaeublin (2011)
Review which describes in detail the optical properties and clinical applications of GNP
In Vivo Toxicity of Intravenously Administered Silica and Silicon Nanoparticles
S. Ivanov (2012)
Studies of silicon nanoparticles uptake and biodegradation in cancer cells by Raman spectroscopy.
E. Tolstik (2016)
Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues
Adi Tzur-Balter (2015)
Biocompatibility of Fe(3)O(4) nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells.
B. Ankamwar (2010)
In vivo delivery of silica nanorattle encapsulated docetaxel for liver cancer therapy with low toxicity and high efficacy.
L. Li (2010)
A Nanostopper Approach To Selectively Engineer the Surfaces of Mesoporous Silicon
Wujun Xu (2014)
Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism.
Wendi Zhang (2012)
In vitro toxicity evaluation of graphene oxide on A549 cells.
Yanli Chang (2011)
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
Prashant Dogra (2018)
Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts.
Ken-Hsuan Liao (2011)
Reducing sugar: new functional molecules for the green synthesis of graphene nanosheets.
C. Zhu (2010)
Hybrid lipid-capped mesoporous silica for stimuli-responsive drug release and overcoming multidrug resistance.
N. Han (2015)
Review on the preparation and biomedical applications of MSiNs
Hollow mesoporous organosilica nanoparticles: a generic intelligent framework-hybridization approach for biomedicine.
Y. Chen (2014)
Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy.
K. Yang (2016)
Degradation and biocompatibility of multistage nanovectors in physiological systems.
J. Martinez (2014)
Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity.
Yu-Shen Lin (2010)
Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage.
Y. Pan (2009)
The combined magnetic field and iron oxide-PLGA composite particles: Effective protein antigen delivery and immune stimulation in dendritic cells.
Chalathan Saengruengrit (2018)
Thickness of functionalized graphene oxide sheets plays critical role in tissue accumulation and urinary excretion: A pilot PET/CT study
Dhifaf A Jasim (2016)
Bioceramics: from bone regeneration to cancer nanomedicine.
M. Vallet-Regí (2011)
•• Review on the biomedical applications of graphene
• Review which describes the toxicity of graphene and related nanostructures
A review of stimuli-responsive nanocarriers for drug and gene delivery.
Srinivas Ganta (2008)
Amine-modified graphene: thrombo-protective safer alternative to graphene oxide for biomedical applications.
S. Singh (2012)
Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery
X. Huang (2014)
Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles.
M. Mahmoudi (2011)
Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells.
I. Slowing (2009)
Intravenous delivery of hydrophobin-functionalized porous silicon nanoparticles: stability, plasma protein adsorption and biodistribution.
Mirkka Sarparanta (2012)
Degradable Drug Carriers: Vanishing Mesoporous Silica Nanoparticles
Karin Moller (2019)
Poly(methyl vinyl ether-alt-maleic acid)-functionalized porous silicon nanoparticles for enhanced stability and cellular internalization.
M. Shahbazi (2014)
Mesoporous silica nanoparticles grafted with a light-responsive protein shell for highly cytotoxic antitumoral therapy.
M. Martínez-Carmona (2015)
Cytotoxicity and Cellular Internalization Studies of Biogenic Gold Nanotriangles in Animal Cell Lines
A. Singh (2011)
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
Lingling Ou (2016)
Green synthesis of graphene and its cytotoxic effects in human breast cancer cells
S. Gurunathan (2013)
Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs.
L. Zhang (2010)
Safety and biocompatibility of graphene: A new generation nanomaterial for biomedical application.
S. Syama (2016)
Shape and surface effects on the cytotoxicity of nanoparticles: Gold nanospheres versus gold nanostars.
P. Favi (2015)
Assessing biocompatibility of graphene oxide-based nanocarriers: A review.
Siaw Fui Kiew (2016)
Preparation of Colloidal Mesoporous Silica Nanoparticles with Different Diameters and Their Unique Degradation Behavior in Static Aqueous Systems
Hironori Yamada (2012)
Oligonucleotide delivery by chitosan-functionalized porous silicon nanoparticles
Morteza Hasanzadeh Kafshgari (2015)
Recent advancements in the use of exosomes as drug delivery systems
E. J. Bunggulawa (2018)
Aqueous colloidal mesoporous nanoparticles with ethenylene-bridged silsesquioxane frameworks.
Chihiro Urata (2011)
Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy.
Y. Hu (2018)
Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer.
W. Miao (2013)
On-chip evaluation of shear stress effect on cytotoxicity of mesoporous silica nanoparticles.
Donghyuk Kim (2011)
Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation.
B. Godin (2010)
Review which describes the synthesis, characteristics and clinical application of SPION
Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery.
S. Heidegger (2016)
Iron Oxide Nanoparticles Induce Autophagosome Accumulation through Multiple Mechanisms: Lysosome Impairment, Mitochondrial Damage, and ER Stress.
X. Zhang (2016)
The biocompatibility of mesoporous silicates.
S. Hudson (2008)
Poly(D,L-lactide-co-glycolide) coated superparamagnetic iron oxide nanoparticles : Synthesis, characterization and in vivo study as MRI contrast agent
D. Patel (2008)
Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy.
K. Yang (2010)
Biopolymer functionalized reduced graphene oxide with enhanced biocompatibility via mussel inspired coatings/anchors.
Chong Cheng (2013)
Successful stabilization of graphene oxide in electrolyte solutions: enhancement of biofunctionalization and cellular uptake.
B. Hong (2012)
Effects of Iron-Oxide Nanoparticle Surface Chemistry on Uptake Kinetics and Cytotoxicity in CHO-K1 Cells
Camille C. Hanot (2015)
Review on stimuli-responsive MSNs for drug delivery
Biomedical applications of graphene. Theranostics
H Shen (2012)
The in vitro and in vivo toxicity of graphene quantum dots.
Yu Chong (2014)
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
B. Chithrani (2006)
Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells.
J. Paris (2018)
Tunable sustained intravitreal drug delivery system for daunorubicin using oxidized porous silicon.
Huiyuan Hou (2014)
Nano-graphene oxide for cellular imaging and drug delivery
X. Sun (2008)
Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings
Qiyi Feng (2018)
The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice
Soyoung Lee (2013)
Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity
H. Kim (2010)
Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers.
E. Guisasola (2018)
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.
H. Maeda (2013)
The three-stage in vitro degradation behavior of mesoporous silica in simulated body fluid
Q. He (2010)
The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems.
Mirkka Sarparanta (2012)
Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time
T. Mironava (2010)
"Manganese Extraction" Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles.
Luodan Yu (2016)
A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity
H. Johnston (2010)
Graphene in biomedicine: opportunities and challenges.
L. Feng (2011)
Drug-loaded liposome-capped mesoporous core-shell magnetic nanoparticles for cellular toxicity study.
M. E. Sharifabad (2016)
Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy.
J. Robinson (2011)
Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy.
M. Wu (2016)
Tailoring the biodegradability of porous silicon nanoparticles.
N. K. Hon (2012)
Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity.
H. Takahashi (2006)
Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles
Eduardo Guisasola (2018)
Selective topotecan delivery to cancer cells by targeted pH-sensitive mesoporous silica nanoparticles
Marina Martínez-Carmona (2016)
Toxicity of graphene in normal human lung cells (BEAS-2B).
N. V. S. Vallabani (2011)
PEGylated nanographene oxide for delivery of water-insoluble cancer drugs.
Zhuang Liu (2008)
Hemocompatibility and macrophage response of pristine and functionalized graphene.
A. Sasidharan (2012)
Biocompatibility of Graphene Oxide
K. Wang (2011)
Biphase stratification approach to three-dimensional dendritic biodegradable mesoporous silica nanospheres.
D. Shen (2014)
In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles.
Oshra Betzer (2017)
A Facile Strategy to Prepare an Enzyme-Responsive Mussel Mimetic Coating for Drug Delivery Based on Mesoporous Silica Nanoparticles.
Chunlin Hu (2017)
Influence of geometry, porosity, and surface characteristics of silica nanoparticles on acute toxicity: their vasculature effect and tolerance threshold.
T. Yu (2012)
The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice
A. Thakor (2011)
Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity.
Elodie Boisselier (2009)
Colorimetric screening of DNA-binding molecules with gold nanoparticle probes.
Min Su Han (2006)
Size-dependent cytotoxicity of gold nanoparticles.
Y. Pan (2007)
Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles.
Jonas G. Croissant (2017)
Preparation of mesoporous calcium doped silica spheres with narrow size dispersion and their drug loading and degradation behavior
Xia Li (2007)
Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy.
M. Mahmoudi (2011)
Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.
S. Wang (2016)
Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species.
Ping'an Ma (2017)
Multifunctional Protocells for Enhanced Penetration in 3D Extracellular Tumoral Matrices.
M. R. Villegas (2018)
A novel approach for targeted delivery to motoneurons using cholera toxin-B modified protocells
Maria A. Gonzalez Porras (2016)
Lipid Bilayer-Gated Mesoporous Silica Nanocarriers for Tumor-Targeted Delivery of Zoledronic Acid in Vivo.
D. Desai (2017)
Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape.
L. Li (2015)
Impact of different PEGylation patterns on the long-term bio-stability of colloidal mesoporous silica nanoparticles
V. Cauda (2010)
Cellular Organelle-Dependent Cytotoxicity of Iron Oxide Nanoparticles and Its Implications for Cancer Diagnosis and Treatment: A Mechanistic Investigation
Chieh-Cheng Huang (2016)
Chemical and magnetic functionalization of graphene oxide as a route to enhance its biocompatibility
K. Urbaś (2014)
The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes.
Changhui Fu (2013)
Behavior and toxicity of graphene and its functionalized derivatives in biological systems.
K. Yang (2013)
Toxicology of silica nanoparticles: an update
S. Murugadoss (2017)
Effect of gold nanoparticle aggregation on cell uptake and toxicity.
Alexandre Albanese (2011)
Bacteria-mediated delivery of nanoparticles and cargo into cells.
D. Akin (2007)
Biodistribution and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles In Vitro and In Vivo
Q. Yu (2018)
Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues.
M. R. Villegas (2015)
Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery
A. Baeza (2015)
Toxicity Assessment of Silica Coated Iron Oxide Nanoparticles and Biocompatibility Improvement by Surface Engineering
M. A. Malvindi (2014)
Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility.
Derrick Tarn (2013)
Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity
K. Choi (2017)
Nanotoxicity of graphene and graphene oxide.
Amedea B. Seabra (2014)
In vitro toxicity studies of polymer-coated gold nanorods.
R. G. Rayavarapu (2010)
Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery.
K. Butler (2016)
In vitro degradation behavior of silica nanoparticles under physiological conditions.
Nanjing Hao (2012)
Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery
J. Paris (2017)
Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
C. Argyo (2014)
Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers.
J. Paris (2015)
Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications.
B. Fadeel (2010)
Therapeutic application of anti-angiogenic nanomaterials in cancers.
S. Mukherjee (2016)
Accumulation and toxicity of intravenously‐injected functionalized graphene oxide in mice
Kai-ping Wen (2015)
Nano‐targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo
D. F. Mardhian (2018)
Biomedical Applications of Graphene
H. Shen (2012)
Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications.
H. Santos (2014)
Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells.
A. Kunzmann (2011)
First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas
S. Bonvalot (2016)
A new targeting agent for the selective drug delivery of nanocarriers for treating neuroblastoma.
Gonzalo Villaverde (2015)
Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy.
Lesan Yan (2018)
Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo
Q. Zhang (2014)
Biocompatible reduced graphene oxide prepared by using dextran as a multifunctional reducing agent.
Y. Kim (2011)
Copper-free azide-alkyne cycloaddition of targeting peptides to porous silicon nanoparticles for intracellular drug uptake.
Chang-Fang Wang (2014)
Ultrasound-induced inertial cavitation from gas-stabilizing nanoparticles.
J. Kwan (2015)
Recent advances in graphene family materials toxicity investigations
A. Jastrzębska (2012)
Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice.
Tianlong Liu (2011)
Encapsulation of VEGF 165 into magnetic PLGA nanocapsules for potential local delivery and bioactivity in human brain endothelial cells
E. Carenza (2015)
Breakable mesoporous silica nanoparticles for targeted drug delivery.
L. Maggini (2016)
Cellular imaging using biocompatible dendrimer-functionalized graphene oxide-based fluorescent probe anchored with magnetic nanoparticles.
Prateek S. Wate (2012)
Bio-degradation study of colloidal mesoporous silica nanoparticles: Effect of surface functionalization with organo-silanes and poly(ethylene glycol)
V. Cauda (2010)
A novel visible light responsive nanosystem for cancer treatment.
M. Martínez-Carmona (2017)
Surface coatings shape the protein corona of SPIONs with relevance to their application in vivo.
Angéla Jedlovszky-Hajdú (2012)
Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells.
C. Medley (2008)
Bovine Serum Albumin (BSA) coated iron oxide magnetic nanoparticles as biocompatible carriers for curcumin-anticancer drug.
H. Nosrati (2018)
A New Property of MCM-41: Drug Delivery System
M. Vallet-Regí (2001)
Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics.
J. Martinez (2013)
Size dependent biodistribution and toxicokinetics of iron oxide magnetic nanoparticles in mice.
L. Yang (2015)
Photochemical synthesis of gold nanorods.
F. Kim (2002)
Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron.
M. Umair (2016)
Silica-coated super-paramagnetic iron oxide nanoparticles (SPIONPs): a new type contrast agent of T1 magnetic resonance imaging (MRI).
M. Iqbal (2015)
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
N. Singh (2010)
Magnetic nanoparticles for theragnostics.
V. Shubayev (2009)
Gold nanorods coated with mesoporous silica shell as drug delivery system for remote near infrared light-activated release and potential phototherapy.
Ji Liu (2015)
Chemical Modification As a Versatile Tool for Tuning Stability of Silica Based Mesoporous Carriers in Biologically Relevant Conditions
Thomas Fontecave (2012)
Magnetic-Responsive Release Controlled by Hot Spot Effect.
E. Guisasola (2015)
Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice.
C. Lasagna-Reeves (2010)
Stability of small mesoporous silica nanoparticles in biological media.
Yu-Shen Lin (2011)
In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration.
K. Yang (2013)
In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles
U. Patil (2015)
Light-Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo.
Xiaju Cheng (2017)
Graphite nanoplatelets and Caenorhabditis elegans: insights from an in vivo model.
E. Zanni (2012)
Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids
Katharina Braun (2016)
Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages in vitro.
K. Mueller (2007)
Multi-functional graphene as an in vitro and in vivo imaging probe.
Ganesh Gollavelli (2012)
Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment
P. Mora-Raimundo (2019)
Tuning mesoporous silica dissolution in physiological environments: a review
J. L. Paris (2017)
Magnetically Triggered Multidrug Release by Hybrid Mesoporous Silica Nanoparticles
A. Baeza (2012)
Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.
Katharine E. Epler (2012)
The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility.
M. Shahbazi (2013)
Biodegradable luminescent porous silicon nanoparticles for in vivo applications.
J. Park (2009)
In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer.
A. Rengan (2015)
Engineered stealth porous silicon nanoparticles via surface encapsulation of bovine serum albumin for prolonging blood circulation in vivo.
Bing Xia (2013)
Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial
P. Lyon (2018)
Molecular bases of cellular iron toxicity.
J. Eaton (2002)
In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylation.
Q. He (2011)
Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation.
M. Xu (2016)
The journey of a drug-carrier in the body: an anatomo-physiological perspective.
N. Bertrand (2012)
Can graphene oxide cause damage to eyesight?
L. Yan (2012)
Single cell array based assay for in vitro genotoxicity study of nanomaterials.
Y. Qiao (2013)
State-of-the-art in design rules for drug delivery platforms: lessons learned from FDA-approved nanomedicines.
Charlene M. Dawidczyk (2014)
Review which describes in detail the synthesis and principal uses in the clinical field of SPION
Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells.
Tanya S. Hauck (2008)
Encapsulation of VEGF165 into magnetic PLGA nanocapsules for potential local delivery and bioactivity in human brain endothelial cells.
E. Carenza (2015)
Exploitation of functional nanomaterials in therapy and diagnostics.
Tapas Sen (2016)
Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.
C. Ashley (2012)
In vivo integrity of polymer-coated gold nanoparticles.
W. Kreyling (2015)
In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles.
Carrie A. Simpson (2013)
Recent advances in porous nanoparticles for drug delivery in antitumoral applications: inorganic nanoparticles and nanoscale metal-organic frameworks
A. Baeza (2017)
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
• Review which describes the principal mechanisms of toxicity caused by SPION
Review which describes the degradability and clearance of silicon and silica nanoparticles
Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers
This paper is referenced by
Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices
V. Buda (2020)
Biodegradable Silica‐Based Nanoparticles with Improved and Safe Delivery of Protoporphyrin IX for the In Vivo Photodynamic Therapy of Breast Cancer
Zachary Lyles (2020)
Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets
Suchada Niamsuphap (2020)
Black phosphorus-based 2D materials for bone therapy
L. Cheng (2020)
Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review
J. Paris (2020)
Cell-Based Nanoparticles Delivery Systems for Targeted Cancer Therapy: Lessons from Anti-Angiogenesis Treatments
P. de la Torre (2020)
Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles.
D. Luther (2020)
Understanding the mechanisms of silica nanoparticles for nanomedicine.
Z. Li (2020)
Stimuli-sensitive crosslinked hydrogels as drug delivery systems: Impact of the drug on the responsiveness.
C. Alvarez-Lorenzo (2020)