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Folic Acid Functionalized PEG Coated Magnetic Nanoparticles For Targeting Anti-cancer Drug Delivery: Preparation, Characterization And Cytotoxicity On Doxorubicin, Zoledronic Acid And Paclitaxel Resistant MCF-7 Breast Cancer Cell Lines

Tuğba Keskin, Serap Yalçın, Ufuk Gunduz
Published 2018 · Chemistry
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ABSTRACT In this study, MNPs were synthesized, coated with biocompatible polyethylene glycol (PEG) and conjugated with folic acid. Crystal and chemical structures, shape, size and magnetic properties of synthesized nanoparticles were characterized. Agglomeration tendency of naked nanoparticles were prevented by oleic acid addition during the synthesis. All synthesized MNPs have been found to exhibit superparamagnetic behavior at 23°C and 37°C. Cytotoxic effects of MNPs were investigated on Doxorubicin, Zoledronic acid and Paclitaxel resistant MCF-7 breast cancer cell lines. The synthesized nanoparticles have been found to be suitable for drug targeting in terms of size, shape, magnetic and cytotoxic properties.
This paper references
Folate-mediated delivery of macromolecular anticancer therapeutic agents.
Yingjuan June Lu (2002)
Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments.
Fabio Sonvico (2005)
Biocompatibility of Fe3O4 Nanoparticles Evaluated by in vitro Cytotoxicity Assays Using Normal, Glia and Breast Cancer Cells
B Ankamwar (2007)
Preparation of Fe3O4/polystyrene composite particles from monolayer oleic acid modified Fe3O4 nanoparticles via miniemulsion polymerization
Feng Yan (2009)
Synthesis and characterization of biocompatible Fe3O4 nanoparticles.
Jing Sun (2007)
Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies
A.K. Gupta (2004)
The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications
Cyrille Boyer (2010)
Biocompatibility of Fe3O4 Nanoparticles Evaluated by in vitro Cytotoxicity Assays Using Normal, Glia and Breast Cancer Cells. Nanotechnology
B. Ankamwar (2007)
Inhibition of α Folate Receptor Resulting in a Reversal of Taxol Resistance in Nasopharyngeal Carcinoma
Wei Li (2012)
Infrared absorption spectra of Buriti (Mauritia flexuosa L.) oil
M.L.S. Albuquerque (2003)
Effect of poly (ethylene glycol) stearate on the phase behavior of monocaprate/ Tween80/ water system and characterization of poly (ethylene glycol) stearete modified solid lipid nanoparticles
X. W. Li (2008)
Magnetic nanoparticles for gene and drug delivery
Stuart C McBain (2008)
Magnetic poly ε-caprolactone nanoparticles containing Fe3O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model
Jingu Gang (2007)
Fundamental Size Limits in Ferroelectricity
Nicola A. Spaldin (2004)
Preparation and characterization of hydrophobic superparamagnetic magnetite gel
Xianqiao Liu (2006)
PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications
Murali M Yallapu (2010)
Magnetic nanoparticles in MR imaging and drug delivery.
Conroy Sun (2008)
PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations
Rouhollah Khodadust (2013)
Biocompatibility of Fe(3)O(4) nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells.
Balaprasad Ankamwar (2010)
Nanomedicine: Design and Applications of Magnetic Nanomaterials, Nanosensors and Nanosystems, by Vijay K. Varadan, Linfeng Chen and Jining Xie
Peter James Dobson (2012)
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake.
Yong Lin Zhang (2002)
Synthesis of bilayer oleic acid-coated Fe3O4 nanoparticles and their application in pH-responsive Pickering emulsions.
Qiang Lan (2007)
Materials science. Fundamental size limits in ferroelectricity.
Nicola A. Spaldin (2004)
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
Ajay Kumar Gupta (2005)
High-Pressure crystal chemistry of spinel (MgAl2O4) and magnetite (Fe3O4): Comparisons with silicate spinels
Larry W. Finger (1986)
Magnetic poly e-caprolactone nanoparticles containing Fe3O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model
J. Gang (2007)
Interaction of Fatty Acid Monolayers with Cobalt Nanoparticles
Nianqiang Wu (2004)
Active targeting schemes for nanoparticle systems in cancer therapeutics.
James D. Byrne (2008)
In vitro evaluation of zoledronic acid resistance developed in MCF-7 cells.
Meltem Demirel Kars (2007)
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
Infrared absorption spectra of Buritti oil
M.L.S. Albuquerque (2003)
und€ uz, U. In Vitro Evaluation of Zoledronic Acid Resistance Developed in MCF-7 Cells
K. M. Demirel (2007)
Preparation of magnetic nanoparticles embedded in polystyrene microspheres
Nguyen Hoang Hai (2009)
On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles.
Ji liang Zhang (2008)
Therapeutic Nanoparticles for Drug Delivery in Cancer
Kwangjae Cho (2008)
Synthesis of variable-sized nanocrystals of Fe3O4 with high surface reactivity
Daniela Caruntu (2004)
Synthesis of highly stable folic acid conjugated magnetite nanoparticles for targeting cancer cells
Sasmita Mohapatra (2007)
Synthesis, properties and application of a novel series of one-ended monooleate-modified poly(ethylene glycol) with active carboxylic terminal
Fei Xiong (2006)
Magnetic Granulometry and Super-Paramagnetism
Charles P. Bean (1956)
Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival
Balazs Györffy (2005)
Oleic acid coating on the monodisperse magnetite nanoparticles
Ling Tao Zhang (2006)
Optimization of iron oxide nanoparticles encapsulation within poly(d,l-lactide-co-glycolide) sub-micron particles.
Lazare Ngaboni Okassa (2007)
Tegafur loading and release properties of magnetite/poly(alkylcyanoacrylate) (core/shell) nanoparticles.
J. Arias (2008)

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