← Back to Search
Mucoadhesive DL-Lactide/Glycolide Copolymer Nanospheres Coated With Chitosan To Improve Oral Delivery Of Elcatonin
Y. Kawashima, H. Yamamoto, H. Takeuchi, Y. Kuno
Published 2000 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity following oral administration. The desired PLGA nanospheres with elcatonin were prepared by the emulsion solvent diffusion method to coat the surface of the resultant nanospheres with a mucoadhesive polymer such as chitosan, poly(acrylic acid), and sodium alginate. Their mucoadhesive properties were evaluated by measuring the nanospheres adsorbed to a rat everted intestinal sac (in vitro). The chitosan-coated nanospheres showed higher mucoadhesion to the everted intestinal tract in saline than the other polymer-coated nanospheres. There was no mucoadhesion site-specificity of the chitosan-coated nanospheres between duodenal, jejunal, and ileal sacs. The payload of drug in the chitosan-coated nanospheres was successfully increased by using the solvent diffusion method in oil. The pattern of drug release of the resultant nanospheres did not differ markedly from that of uncoated nanospheres. The chitosan-coated nanospheres with elcatonin were administered intragastrically to fasted Wistar rats. The chitosan-coated nanosphere reduced significantly the blood calcium level compared with elcatonin solution and uncoated nanospheres, and the reduced calcium level was sustained for a period of 48 hr. Even under nonfasting conditions, the mucoadhesion of chitosan-coated nanospheres was unaltered and the reduction in blood Ca levels was maintained satisfactorily.
This paper references
Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery.
S. Miyazaki (1994)
Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer.
M. Longer (1985)
Effects of the Mucoadhesive Polymer Polycarbophil on the Intestinal Absorption of a Peptide Drug in the Rat
C. Lehr (1992)
Chitosan and sodium alginate based bioadhe- sive tablets for intraoral drug
S. Miyazaki (1994)
Evaluation of a mucoadhesive buccal patch for delivery of peptides: in vitro screening of bioadhesion.
C. Li (1998)
Intestinal peptide and protein delivery: novel bioadhesive drug-carrier matrix shielding from enzymatic attack.
A. Bernkop-Schnürch (1998)
In Vitro and in Vivo Evaluation of Mucoadhesive Microspheres Prepared for the Gastrointestinal Tract Using Polyglycerol Esters of Fatty Acids and a Poly(acrylic acid) Derivative
Y. Akiyama (2004)
Properties of a peptide containing DL-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods.
Y. Kawashima (1998)
Development and in vitro evaluation of a buccoadhesive pindolol tablet formulation.
B. Dortunç (1998)
Bioadhe- sive polymers as platforms for oral controlled drug deliv- ery III: Oral delivery of chlorothiazide using a bioadhe- sive polymer
M. A. Longer (1985)
In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers.
Y. Ogawa (1988)
Ponchel, Bi- oadhesion of lectin-latex conjugates to rat intestinal mu- cosa
J. M. Irache (1996)
Investigation of surface properties of some polymers by a thermodynamic and mechanical approach: possibility of predicting mucoadhesion and biocompatibility.
P. Esposito (1994)
Development and in vitro evaluation of a buccoadhesive pindolol tablet formu- lation
B. Dortunc (1998)
A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid.
Y. Ogawa (1988)
New approach for oral administration of insulin with po- lyalkylcyanoacrylate nanocapsules as drug
C. Damge (1988)
Physico- chemical properties and assay of elcatonin
Y. Nogata (1982)
Lovrecich, Investigation of surface properties of some polymers by a thermody- namic and mechanical approach: possibility of predicting mucoadhesion and biocompatibility, Biomaterials
P. Esposito (1994)
Mucoadhesion of colloidal particulate systems in the gastro-intestinal tract
G. Ponchel (1997)
New Approach for Oral Administration of Insulin With Polyalkylcyanoacrylate Nanocapsules as Drug Carrier
C. Damgé (1988)
Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches
Shinji Sakuma (1997)
Toguchi, In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative, Pharm
Y. Akiyama (1995)
Effects of Polyacrylic Polymers on the Degradation of Insulin and Peptide Drugs by Chymotrypsin and Trypsin
J. M. Bai (1996)
[Development of topical drug delivery systems utilizing polymeric materials].
Y. Machida (1993)
This paper is referenced by
PHYSICAL STABILITY OF POLY (LACTIC-CO-GLYCOLIC ACID) AND PLGA/CHITOSAN NANOPARTICLES AND CHEMICAL STABILITY OF ENTRAPPED ALPHA-TOCOPHEROL AND LUTEIN
A Thesis (2014)
Cationic gelatin nanoparticles for drug delivery to the ocular surface: in vitro and in vivo evaluation
Ching Li Tseng (2013)
Zwitterionic Chitosan Derivative, a New Biocompatible Pharmaceutical Excipient, Prevents Endotoxin-Mediated Cytokine Release
Gaurav Bajaj (2012)
Is the oral route possible for peptide and protein drug delivery?
M. Morishita (2006)
Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.
A. des Rieux (2006)
Bioadhesion: new possibilities for drug administration?
J. Woodley (2001)
Design of Nano-particulate Systems for Drug Delivery
H. Takeuchi (2003)
Synthesis, characterization and ultrasonic study of aqueous suspensions containing polymeric nano particles of poly (L-lactide)
G. C. J. Swarnavalli (2015)
Rheumatoid arthritis and the challenge of using nanoparticles for its treatment
L. Chabib (2018)
Development of in situ gel containing asiaticoside/cyclodextrin complexes. Evaluation in culture human periodontal ligament cells (HPLDCs).
Hay Man Saung Hnin Soe (2020)
In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases.
D. Guggi (2003)
Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale
J. das Neves (2011)
Physical Stability of Poly (lactic-co-glycolic acid) and PLGA/Chitosan Nanoparticles and Chemical Stability of Entrapped Alpha-Tocopherol and Lutein
M. Whaley (2014)
- Antibody-Conjugated Nanoparticles of Biodegradable Polymers for Targeted Drug Delivery
Birsen Demirbag (2011)
Nanotechnology Delivery Systems of Coenzyme Q10: Pharmacokinetic and Clinical Implications
Shweta Paroha (2017)
Delivery of LMW Heparin via Surface Coated Chitosan/peg-Alginate Microspheres Prevents Thrombosis
T. Chandy (2002)
In vitro and in vivo evaluation of sustained release chitosan-coated ketoprofen microparticles.
T. Yamada (2001)
Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery.
X. Y. Xiong (2007)
Nanoparticles as protein and gene carriers to mucosal surfaces.
M. de la Fuente (2008)
MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
G. Ruíz (2006)
Triple therapy-based targeted nanoparticles for the treatment of Helicobacter pylori
S. Ramteke (2008)
Self-assembled Chitosan-Ceramide Nanoparticle for Enhanced Oral Delivery of Paclitaxel
G. Battogtokh (2014)
Nanotechnology in Biomaterials : Nanoparticulates as Drug Delivery Systems
Birsen Demirbag (2012)
Nanomedicines for oral administration based on diverse nanoplatform
Taehoon Sim (2016)
In vitro–in vivo evaluation of chitosan-PLGA nanoparticles for potentiated gastric retention and anti-ulcer activity of diosmin
Walaa Ebrahim Abd El Hady (2019)
PLGA Nanoparticle Design and Preparation for DDS and Medical Device
H. Tsujimoto (2018)
Development and In Vitro Evaluation of Surface Modified Poly(lactide-co-glycolide) Nanoparticles with Chitosan-4-Thiobutylamidine
V. Grabovac (2007)
BIODEGRADABLE POLYMER MICRO- AND NANOPARTICLES AS PROTEIN DELIVERY SYSTEMS: INFLUENCE OF MICROPARTICLE MORPHOLOGY AND IMPROVEMENT OF PROTEIN LOADING CAPACITY OF NANOPARTICLES
C. Cai (2007)
Efficacy and Mechanism of Action of Chitosan Nanocapsules for Oral Peptide Delivery
C. Prego (2006)
The use of multifunctional polymers for non-invasive peptide and protein application
A. Bernkop-Schnürch (2000)
Preparation and Characterization of Novel Drug-Inserted-Montmorillonite Chitosan Carriers for Ocular Drug Delivery
Dongzhi Hou (2015)
Poly (D, L-lactide-co-glycolide) and chitosan particles for oral delivery of model lipophilic vitamin
Abitha Murugeshu (2009)See more