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FBH1 Promotes DNA Double-strand Breakage And Apoptosis In Response To DNA Replication Stress

Yeon-Tae Jeong, M. Rossi, Lukas Cermak, A. Saraf, L. Florens, M. Washburn, P. Sung, C. Schildkraut, M. Pagano
Published 2013 · Biology, Medicine

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Enzymatic activity of the UvrD DNA helicase FBH1 is required for the efficient induction of DSBs and apoptosis specifically in response to DNA replication stress.
This paper references
Skaar for critical reading of the manuscript ; and C. Sørensen and J. Bartek for sharing unpublished results
M The Authors Thank
DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics.
D. Tabb (2002)
Stress-Induced Phosphorylation of S. pombe Atf1 Abrogates Its Interaction with F Box Protein Fbh1
C. Lawrence (2009)
Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.
E. Raderschall (1999)
Shotgun identification of protein modifications from protein complexes and lens tissue
M. MacCoss (2002)
The DNA damage response: making it safe to play with knives.
Alberto Ciccia (2010)
Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair
Chikako Sakaguchi (2007)
Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse
香崎 正宙 (2007)
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
E. Petermann (2010)
RecQ helicases: multifunctional genome caretakers
W. Chu (2009)
Phosphorylated H 2 Ax is not an unambiguous marker for DNA double - strand breaks
V. D’Angiolella
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse
Karoline C. Manthey (2007)
Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress.
Corentin Laulier (2010)
The Human F-Box DNA Helicase FBH1 Faces Saccharomyces cerevisiae Srs2 and Postreplication Repair Pathway Roles
I. Chiolo (2007)
SCFhFBH 1 can act as helicase and E 3 ubiquitin ligase
J. H. Kim
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Yeon-Tae Jeong (2013)
Mammalian Fbh 1 is important to restore normal mitotic progression following decatena - tion stress
C. Laulier (2010)
mediates DSBs upon replication stress @BULLET Jeong et al
RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination
L. Barber (2008)
Replication Stress-Induced Chromosome Breakage Is Correlated with Replication Fork Progression and Is Preceded by Single-Stranded DNA Formation
W. Feng (2011)
Hong, respectively , for continuous support This work was funded by grants from the National Institutes of Health (R01-GM057587, R37-CA076584, and R21-CA161108 to M
M Pagano
SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins
L. Busino (2007)
SCFCyclin F controls centrosome homeostasis and mitotic fidelity via CP110 degradation
Vincenzo D’Angiolella (2010)
The Novel Human DNA Helicase hFBH1 Is an F-box Protein*
J. Kim (2002)
Proteomic analysis by multidimensional protein identification technology.
L. Florens (2006)
Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities
Kasper Fugger (2009)
Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse
Masaoki Kohzaki (2007)
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
J. Eng (1994)
Inhibition of homologous recombination by the PCNA-interacting protein PARI.
G. Moldovan (2012)
A DNA Helicase from Schizosaccharomyces pombeStimulated by Single-stranded DNA-binding Protein at Low ATP Concentration*
J. Park (1997)
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
M. Washburn (2001)
Large - scale analysis of the yeast proteome by multidimensional protein identification technol
Y. Zhang (2001)
The F-Box DNA Helicase Fbh1 Prevents Rhp51-Dependent Recombination without Mediator Proteins
F. Osman (2005)
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110
V. D’Angiolella (2010)
SCFhFBH1 can act as helicase and E3 ubiquitin ligase.
J. Kim (2004)
SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP 110 degradation
Vincenzo D’Angiolella (2010)
Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks
J. Cleaver (2011)
Characterization of homologous recombination induced by replication inhibition in mammalian cells
Y. Saintigny (2001)
Replication protein A phosphorylation and the cellular response to DNA damage.
Sara K. Binz (2004)
Analysis of protein dynamics at active, stalled, and collapsed replication forks.
Bianca M. Sirbu (2011)
Role of the Schizosaccharomyces pombe F-Box DNA Helicase in Processing Recombination Intermediates
T. Morishita (2005)
Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteins.
Y. Zhang (2010)
Large - scale analysis of the yeast proteome by multidimensional protein identification technol
M. P. Washburn (2001)

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Nikolay Tsanov (2014)
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W. Chu (2015)
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Agathe Bacquin (2013)
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M. Soler (2015)
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Yeon-Tae Jeong (2018)
Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?
R. Tsai (2016)
The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.
J. Guervilly (2015)
Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins.
Nana Zheng (2016)
Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair
Colleen C Caldwell (2020)
DNA helicases involved in DNA repair and their roles in cancer
R. Brosh (2013)
Synergistic effect of two E2 ubiquitin conjugating enzymes in SCFhFBH1 catalyzed polyubiquitination
J. Kim (2015)
Replication protein A as a major eukaryotic single-stranded DNA-binding protein and its role in DNA repair
Y. Krasikova (2016)
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The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.
Antonio Marzio (2019)
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Catherine J. Potenski (2013)
The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation
H. Galick (2017)
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response
A. Maréchal (2015)
Replication Catastrophe: When a Checkpoint Fails because of Exhaustion.
L. Toledo (2017)
Rare Coding Variants and Breast Cancer Risk: Evaluation of Susceptibility Loci Identified in Genome-Wide Association Studies
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H. Gaillard (2015)
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