Online citations, reference lists, and bibliographies.
← Back to Search

THE GENETIC CONTROL OF ANTIBODY SPECIFICITY

E. Mozes, H. Mcdevitt, J. Jaton, M. Sela
Published 1969 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The immune response to a synthetic polypeptide built on multichain polyproline, poly-L-(Tyr,Glu)-poly-L-Pro-poly-L-Lys [(T,G)-Pro--L], in the offspring of a cross between DBA/1 and SJL mice is under a genetic control superficially similar to the one operating for the immune response to a similar synthetic polypeptide built on multichain polyalanine, poly-L-(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys [(T,G)-A--L], in the offspring of a cross between CBA and C57 mice. In both cases, the genetic control is a quantitative trait in which the major gene(s) is (are) dominant and the trait is not linked to any of the known structural genes coding for mouse immunoglobulin heavy chains. However, the genetic control of response to (T, G)-Pro--L, designated immune response-3 (Ir-3), is qualitatively different from the one operating for (T,G)-A--L [immune response-1 (Ir-1)] in that it is not linked to the histocompatibility-2 (H-2) locus. A study of the immune response to a related polypeptide built on multichain polyproline, poly-L-(Phe,Glu)-poly-L-Pro-poly-L--Lys [(Phe, G)-Pro--L], in the DBA/1 x SJL cross has shown a genetic control of antibody specificity. F1 x DBA/1 backcross anti-(Phe, G)-Pro--L sera segregate in their ability to bind (T,G)-Pro--L, and there is no linkage of anti-(T,G)-Pro--L binding capacity with the H-2s allele of the SJL grandparent. F1 x SJL anti-(Phe, G)-Pro-L sera segregate in their capacity to bind poly-L-(Phe,Glu)-poly-D,L-Ala-poly-L-Lys [(Phe, G)-A--L] and the ability to bind (Phe, G)-A--L is clearly linked to the H-2q allele from the DBA/1 grandparent. Thus, in mice all responding well to a given antigen [(Phe, G)-Pro--L], the specificity of the antibodies produced [i.e., anti-(Phe,G) or anti-prolyl] is genetically determined. Cross-inhibition of binding m (DBA/1 x SJL)F1 anti-(Phe,G)-Pro--L antisera indicates that the anti-(Phe,G) and anti-prolyl specificities are a function of two separate and largely non-crossreacting antibody populations.
This paper references
10.1111/J.1699-0463.1953.TB00247.X
Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.
O. Ouchterlony (1953)
10.1038/088566a0
The Precipitin Reaction
O. Plescia (1957)
10.1016/0003-9861(60)90624-x
On the mechanism of enzyme action. 71. Acylations of trypsin in organic solvents.
S. Vratsanos (1960)
10.1097/00006534-196101000-00038
The use of pvp as a developing agent in mouse hemagglutination tests.
J. Stimpfling (1961)
10.1042/BJ0890114
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.
F. Greenwood (1963)
10.1126/science.142.3590.400
Genetic Differences in Antibody Production to Determinant Groups on Insulin
E. Arquilla (1963)
10.1016/0006-291X(63)90329-2
Allotypy in rabbit 19S protein.
C. Todd (1963)
Allotypy in rabbit 19 S protein
C. W. Todd (1963)
10.1042/BJ0930566
Antigenicity of some new synthetic polypeptides and polypeptidyl gelatins.
S. Fuchs (1964)
10.1084/JEM.121.3.415
IMMUNOGLOBULIN ISOANTIGENS (ALLOTYPES) IN THE MOUSE I. GENETICS AND CROSS-REACTIONS OF THE 7S γ2A-ISOANTIGENS CONTROLLED BY ALLELES AT THE IG-1 LOCUS
L. Herzenberg (1965)
10.1084/JEM.122.4.771
GENETIC CONTROL OF COMBINING SITES OF INSULIN ANTIBODIES PRODUCED BY GUINEA PIGS
E. Arquilla (1965)
10.1084/JEM.122.3.517
GENETIC CONTROL OF THE ANTIBODY RESPONSE
H. Mcdevitt (1965)
Immunoglobulin isoantigens (aliotypes) in the mouse. I. Genetics and cross-reactions of the 7S
L A Herzenberg (1965)
10.1101/SQB.1967.032.01.019
Location of Specificity and Allotypic Amino Acid Residues in Antibody Fd Fragments
M. Koshland (1967)
10.1111/J.1423-0410.1967.TB03388.X
Tertiary relationships necessary for antigenic determinants and biological activity of insulin.
E. Arquilla (1967)
10.1073/PNAS.57.2.353
Somatic recombination of duplicated genes: an hypothesis on the origin of antibody diversity.
G. Edelman (1967)
10.1038/216330a0
Linked Groups of Residues in Immunoglobulin κ Chains
C. Milstein (1967)
10.1084/JEM.126.5.969
Genetic control of the antibody response. II. Further analysis of the specificity of determinant-specific control, and genetic analysis of the response to (H,G)-A--L in CBA and C57 mice.
H. Mcdevitt (1967)
Light chain evolution. Cold Spring Harbor Syrap
L Hood (1967)
Identical allotypic markers of heavy polypeptide chains present in different immunoglobulin classes.
B. Pernis (1968)
10.1146/ANNUREV.GE.02.120168.001233
Genetics of Antibodies
L. Herzenberg (1968)
Genetic control of the antibody response. 3. Qualitative and quantitative characterization of the antibody response to (T,G)-A--L in CBA and C57 mice.
H. Mcdevitt (1968)
Role of optical configuration in the immunogenicity and specificity of synthetic antigens derived from multichain polyproline.
J. Jaton (1968)
10.1084/JEM.128.1.1
GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE
H. Mcdevitt (1968)
Genetic control of aspects of the immune response
Pinchuck (1968)
10.1126/science.163.3872.1207
Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type
H. Mcdevitt (1969)
10.1084/JEM.130.3.493
THE NATURE OF THE ANTIGENIC DETERMINANT IN A GENETIC CONTROL OF THE ANTIBODY RESPONSE
E. Mozes (1969)
10.1042/BJ1120173
Variation in the N-terminal sequence of heavy chains of immunoglobulin G from rabbits of different allotype.
J. Wilkinson (1969)
Genetic control of the immune response in mice. I. Segregation data and localization to the fifth linkage group of a gene affecting antibody production.
D. Gasser (1969)
10.1042/BJ1170002PA
Genetic control of the antibody response.
E. Lennox (1970)
10.1136/jcp.s1-4.1.1
The mechanism of enzyme action.
B. Rabin (1970)
IDENTIFICATION OF A GENE LOCUS FOR yG , IMMUNOGLOBULIN H CHAINS AND ITS LINKAGE TO THE H CHAIN CHROMOSOME REGION IN THE MOUSE * BY
J. Minna



This paper is referenced by
10.1111/J.1439-0388.1971.TB01368.X
Antibody Production Studied by Means of the LHG Assay in two Inbred Strains of Mice and their Crosses1
H. Kräusslich (2010)
10.1038/gene.2008.77
Rheumatoid arthritis: a view of the current genetic landscape
M. Coenen (2009)
10.1002/art.23953
Clinical images: incidental retinal vasculopathy: a clue to diagnosing systemic disease.
S. Sharma (2008)
10.1002/ART.23127
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.
K. N. Verpoort (2007)
10.1002/ART.22716
Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis.
A. H. M. van der Helm-van Mil (2007)
10.1007/BF01733077
Immunantwort mit monoklonaler Differenzierung
D. G. Braun (2005)
10.1007/BF01564074
Genetic control of the immune response to a thymus independent synthetic polypeptide
Anne -Marie Schmitt-Verhulst (2005)
10.1007/BF01572311
Expression of immune response (Ir) genes in T and B cells
E. Mozes (2005)
10.1007/BF01575676
Immune response deficiency of BSVS mice
D. Briles (2005)
Idcnnficanon of Different Antigenic Determinants Within the Synthetic Multichain Co-Polymer Poly(Tyr,Glu)-PolyAla--PolyLys As Recognized by the Chicken I. Significance of the Poly Ala--PolyLys Backbone and Identification of PoIy-D'Alanine as the Antigenic Determinant in Backbone'Directed Responses
(2005)
10.1007/BF01843998
Genetic control of igG2a production in the response to sheep erythrocytes
M. Seman (2005)
10.1007/BF01564052
Inheritance in the rat of the antibody response to two different determinants of (T,G)-A--L
Claus B. Koch (2005)
10.1007/BF01564064
Immune response of mice to Thy-1.1 antigen: Studies on congenic lines
M. Zaleski (2005)
10.1007/BF01570436
Genetic control of susceptibility to experimental allergic encephalomyelitis in mice
Z. Lando (2005)
10.1007/BF01570506
The T-Cell factor specific for poly(Tyr, Glu)-Poly(Pro)-Poly(Lys) is an I-Region gene product
Ronit Isac (2005)
10.1007/BF01576972
Antigen-Specific T-cell factors in the immune response to poly(Tyr,Glu)-poly(Pro)-poly(Lys)
Ronit Isac (2005)
10.1007/BF00364443
Genetic regulation of the antibody response to H-2Db alloantigens in mice. I. Differences in activation of helper T cells in C57BL/10 and BALB/c congenic strains
D. Wernet (2004)
10.1007/BF00201977
The challenge of the combined use of synthetic antigens and synthetic adjuvants
M. Sela (2004)
10.1016/S0069-8032(04)43017-4
My world through science
M. Sela (2004)
CELLULAR BASIS OF GENETIC CONTROL OF IMMUNITY antibody response to a synthetic polypeptide : transfer of response with spleen cells or lymphoid precursors
Gions W I T H I N POLY-PHE (2003)
I. DIFFERENCES IN FREQUENCY OF SPLENIC PRECURSOR CELL~ SPECIFIC FOR A SYNTHETIC POLYPEPTIDE DERIVED FROM MULTICHAIN POLYPROLINE
E. Mozes (2003)
GENETIC CONTROL OF T H E I M M U N E RESPONSE TO STAPHYLOCOCCAL NUCLEASE I. IR-NASE: CONTROL OF THE ANTIBODY RESPONSE TO NUCLEASE BY THE IR REGION OF THE MOUSE H-2 COMPLEX BY EUGENE
E. Lozner (2003)
V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OF L-GLUTAMIC
H. Bluestein (2003)
10.1002/EJI.1830241036
Dichotomy between the T and the B cell epitopes of the synthetic polypeptide (T,G)‐A–L
Einat Zisman (1994)
10.1016/B978-0-12-635507-9.50007-6
Ir Genes: Antigen-Specific Genetic Regulation of the Immune Response
J. Berzofsky (1987)
10.31274/RTD-180813-1795
Genetic control of the humoral immune response to avian egg white lysozymes in the chicken
M. Flanagan (1987)
10.1016/0142-9612(84)90048-6
Effect of the chemical structure of N- (2- hydroxypropyl) methacrylajnide copolymers on their ability to induce antibody formation in inbred strains of mice
B. Říhová (1984)
10.1016/S0769-2625(84)81187-3
Speculations on how Ia antigens (Ir genes) influence the specificity of the immune response.
H. Mcdevitt (1984)
10.1007/978-1-4612-5633-5_77
Analysis of the T Cell Recognition System Using (T,G)-A--L Specific Helper T Cell Lines
E. Mozes (1983)
10.1002/BIP.360220155
From synthetic antigens to synthetic vaccines
M. Sela (1983)
10.14288/1.0095910
Genetics of the immune response to ferredoxin : assessment of control at the determinant level
L. Sikora (1983)
10.1016/0161-5890(82)90252-8
The immune response to ferredoxin: characterization of a major idiotype in serum using monoclonal antibody derived by cell fusion.
M. Weaver (1982)
See more
Semantic Scholar Logo Some data provided by SemanticScholar