Referencing for people who value simplicity, privacy, and speed.Get Citationsy
← Back to Search
Escape Of Metastasizing Clonal Tumor Cell Variants From Tumor-specific Cytolytic T Lymphocytes
K. Bosslet, V. Schirrmacher
Published 1981 · Medicine, Biology
Save to my Library
Download PDFAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
A metastasizing variant of a chemically induced lymphoma from a DBA/2 mouse is shown to carry a distinct tumor-associated transplantation antigen (TATA), which can be recognized by syngeneic secondary anti- tumor cytolytic T lymphocytes (CTL). During metastasis of twice-cloned cell lines of this tumor, variants develop that are specifically immunoresistant to lysis by anti-tumor CTL. The variants are detected in the spleen of normal syngeneic mice. They remain stable over long- term passage in tissue culture. The high frequency with which these immunoresistant metastatic variants develop was found to explain the relative ineffectiveness of specific immunization against this metastatic tumor. Compared with organ-selective metastatic variants, the immunoresistant tumor variants seem to arise with a much higher frequency. The change in TATA expression described here differs from antibody-induced antigenic modulation in that it is more stable and genetically transmitted.
This paper references
Metastasis results from preexisting variant cells within a malignant tumor.
I. Fidler (1977)
Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. VIII. Expression and shedding of Fc gamma receptors on metastatic tumor cell variants.
V. Schirrmacher (1979)
Shifts in tumor cell phenotypes induced by signals from the microenvironment. Relevance for the immunobiology of cancer metastasis.
V. Schirrmacher (1980)
Hepatocyte-tumor cell interaction in vitro. I. Conditions for rosette formation and inhibition by anti-H-2 antibody
V. Schirrmacher (1980)
Response ofsyngeneic murine lymphomata to immunotherapy in relation to the antigenicity of the tumor
M. L. Lohmann-Matthes (1972)
Modulation of thymus-leukemia antigens on mouse leukemia cells induced by IgG, but not IgM, antibody.
C. Stackpole (1980)
Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL cell-surface antigens and THY1.
J. Hilgers (1980)
Modification of the antigenic structure of the cell membrane by thymus-leukemia (TL) antibody.
E. Boyse (1967)
Metastatic tumor cell variants with increased resistance to infection by Semliki Forest virus.
D. Barz (1981)
Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice. VI. Similar specificity patterns of protective anti‐tumor immunity in vivo and of cytolytic T cells in vitro
K. Bosslet (1979)
Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice X. Immunoselection of tumor variants differing in tumor antigen expression and metastatic capacity
V. Schirrmacher (1980)
Organ specificity of blood - borne metastasis determined by cell adhesion ?
V. Schirrmacher (1975)
Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. VII. Interaction of metastasizing and nonmetastasizing tumors with normal tissue in vitro.
M. Lohmann‐Matthes (1980)
THE INOSINIC ACID PYROPHOSPHORYLASE ACTIVITY OF MOUSE FIBROBLASTS PARTIALLY RESISTANT TO 8-AZAGUANINE.
J. Littlefield (1963)
Spontaneous shedding and antibody induced modulation of histocompatibility antigens on murine lymphomata: Correlation with metastic capacity.
G. Davey (1976)
This paper is referenced by
Successful Application of a Virus-Modified Tumor Vaccine for Anti-Metastatic Cancer Immunotherapy
V. Schirrmacher (1989)
NKG2D CAR T‐cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors
P. Spear (2013)
Characterization of an extracellular matrix-degrading protease derived from a highly metastatic tumor cell line.
M. Kramer (1985)
Successful elimination of large established tumors and avoidance of antigen-loss variants by aggressive adoptive T cell immunotherapy.
K. Matsui (2003)
A rapid method for the isolation of metastasizing tumour cells from internal organs with the help of isopycnic density-gradient centrifugation in Percoll.
K. Bosslet (1981)
Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.
C. Aslakson (1992)
Studies on interleukin 2 receptor expression and IL-2 production by murine T cell lymphomas.
T. Diamantstein (1985)
Sensitivity to macrophages decreases with tumor progression in the AKR lymphoma.
T. Kaptzan (2000)
SUPPRESSOR CELLS: T CELLS AND MACROPHAGES1
R. North (1985)
Heterogeneity and clonal variation related to cell surface expression of a mouse lung tumor-associated antigen quantified using flow cytometry.
D. Bahler (1984)
Progressive growth of immunogenic tumors: relationship between susceptibility of ascites P815 tumor cells to T-cell-mediated lysis and immune destruction in vivo.
J. Fahey (1987)
Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells
P. Baetselier (2004)
Prospects for the treatment of B cell tumors using idiotypic vaccination.
A. George (1989)
Möglichkeiten des Einsatzes zytotoxischer T-Zellen in der Immuntherapie von Tumoren
H. Haubeck (1985)
High‐frequency generation of new immunoresistant tumor variants during metastasis of a cloned murine tumor line (ESb)
K. Bosslet (1982)
Tumor cell diversity and host responses in cancer metastasis--part II--host immune responses and therapy of metastases.
G. Nicolson (1983)
Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes.
H. Schorlemmer (1983)
Immunoresistant metastatic tumor variants can re‐express their tumor antigen after treatment with DNA methylation‐inhibiting agents
P. Altevogt (1986)
Modification of tumor cells by a low dose of Newcastle Disease Virus.
Paul Von Hoegen (1989)
Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites.
G. Nicolson (1988)
Tumor cell metastasis.
V. P. Terranova (1986)
Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis.
I. Vlodavsky (1983)
The selective nature of metastasis
J. Talmadge (2004)
Characterization of L5178Y cell phenotypes isolated during progression of the tumor-dormant state in DBA2 mice.
Trainer Dl (1984)
Specific eradication of micrometastases by transfer of tumour-immune T cells from major-histocompatibility-complex congenic mice
V. Schirrmacher (2005)
Cancer metastasis. Organ colonization and the cell-surface properties of malignant cells.
G. Nicolson (1982)
In-vitro resistance of cloned human glioma cells to natural killer activity of allogeneic peripheral lymphocytes.
K. Zaenker (1982)
Antigenic tumor cell variants obtained with mutagens.
T. Boon (1983)
Different expression of Lyt differentiation antigens and cell surface glycoproteins by a murine T lymphoma line and its highly metastatic variant
P. Altevogt (1982)
Down-regulation of the antitumor immune response.
R. North (1985)
In vivo evolution of adenovirus 2-transformed cell virulence associated with altered E1A gene function.
J. L. Cook (1988)
Endogenous Mouse Mammary Tumor Viruses (Mtv): New Roles for an Old Virus in Cancer, Infection, and Immunity
Michael P Holt (2013)See more