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In Vivo Effects Of Antibodies To Immune Response Gene Products. I. Haplotype-specific Suppression Of Humoral Immune Responses With A Monoclonal Anti-I-A
J. Rosenbaum, N. Adelman, H. Mcdevitt
Published 1981 · Biology, Medicine
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Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I-Ak, but not to antigen (T,G)-A--L, under the control of I-Ab. This relative specificity was lost if the antigen was given in complete Freund's adjuvant rather than aqueous solution. The monoclonal antibody reduced the antibody titer in an ongoing, secondary response as well. Several potential mechanisms can be postulated for this effect. This haplotypic specificity might ultimately be relevant to human disease.
This paper references
Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine.
M. Sela (1962)
Studies on the chemical basis on the antigenicity of proteins
M. Sela (1962)
Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type
H. Mcdevitt (1969)
Solid-phase radioimmune assay. Using 3 H-labeled antigen for the mouse olfactory bulb specific protein.
F. Margolis (1972)
Genetic control of the immune response. A selective defect in immunologic (IgG) memory in nonresponder mice
F C Grumet (1972)
Genetic control of the immune response. Mapping of the It-1 locus
H O Mcdevitt (1972)
Genetic control of the immune response. A selective defect in immunologic (IgG) memory in nonresponder mice.J
F. C. Grumet (1972)
ALLOANTISERUM-INDUCED INHIBITION OF IMMUNE RESPONSE GENE PRODUCT FUNCTION
E. Shevach (1974)
GENETIC CONTROL OF THE IMMUNE RESPONSE
P. Lonai (1974)
Inhibition of immune responses m vitro by specific antiserums to Ia antigens Alloantiserum-induced inhibition of immune response gene product function. II. Genetic analysis of target antigens
J A Frelinger (1974)
Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L- glutamic acid50-L-tyrosine50 (GT)
P. Debré (1975)
Inhibition of immune responses in vitro by specific antiserums to Ia antigens.
J. Frelinger (1975)
THE ROLE OF PRODUCTS OF THE HISTOCOMPATIBILITY GENE COMPLEX IN IMMUNE RESPONSES
D. Katz (1975)
T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera.
R. Schwartz (1976)
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex
T. Tada (1976)
Antigen specific T cell factors in the genetic control of the immune response to poly(tyr,glu)poly(pro)--poly(lys).
E. Mozes (1976)
A Cardinal Role for I‐Region Antigens (Ia) in Immunological Enhancement, and the Clinical Implications
D. A. Davies (1976)
A cardinal role for I region antigens (Ia) in immunological enhancement, and clineal implications. Transplant
D.A.L. Davies (1976)
Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex.
M. Pierres (1977)
Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.
M. Greene (1977)
The association between genes in the major histocompatibility complex and disease susceptibility,.
T. Sasazuki (1977)
INHIBITORY EFFECT OF ANTI-Ia SERA ON PROLIFERATIVE RESPONSES TO (H,G)-A--L and (Phe,G)-A--L
P. Lonai (1978)
Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.
V. T. Oi (1978)
Function of macrophages in genetic control of immune responsiveness.
A. Rosenthal (1978)
The major histocompatibility complex of the mouse.
Jan Klein (1979)
Organization of the immune response genes.
J. Uhr (1979)
Major histocompatibility complex-restricted self recognition. A monoclonal anti-I-Ak reagent blocks helper T cell recognition of self major histocompatibility complex determinants
R. Hodes (1980)
Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30)
S. Broder (1980)
Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements
J. Sprent (1980)
In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia.
D. Meruelo (1980)
Definitive mapping of the immune response gene(s) for (T,G)-A--L to the I-A subregion.
M. Markman (1980)
Mechanisms of regulation of cell-mediated immunity: anti-I-A alloantisera interfere with induction and expression of T-cell-mediated immunity to cell-bound antigen in vivo.
L. Perry (1980)
Inhibition of antigen-specific proliferation by antisera recognizing antigens encoded by the human DR locus may be due to active suppression
A. V. Muchmore (1980)
Solid phase radioimmune assays
T. T. Tsu (1980)
T cell subset interactions in the regulation of syngeneic tumor immunity.
L. Perry (1981)
Different macrophage populations distinguished by means of fluorescent polysaccharides. Recognition and properties of marginal‐zone macrophages
J. Humphrey (1981)
Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection.
W. Green (1981)
Genetic control of the immune response to myoglobins. IV. Inhibition of determinant-specific Ir gene-controlled antigen presentation and induction of suppression by pretreatment of presenting cells with anti-Ia antibodies.
J. Berzofsky (1981)
Suppression of immunoglobulin (Ig) production by anti-Ia antibody (Ab) is dependent on prostaglandin production (PG)
J. Ceuppens (1981)
J. Exp. Med
This paper is referenced by
Suppressor mechanisms in tumor immunity
G. Nepom (2005)
Identification on I-Ak molecules of a functional site recognized by proliferating T-lymphocytes
P. Dubreuil (2004)
Correlation between increase in Ia-bearing macrophages and induction of T cell-dependent antitumor activity by Lactobacillus casei in mice
Ikuo Kato (2004)
Regulation of the immune response to antigens on the malignant cell surface
JeffreyA. Drebin (2004)
New therapeutic approaches to autoimmune disease
N. Talal (2004)
Anti-major histocompatibility complex class II treatment prevents graft rejection in the hamster-to-rat cardiac xenograft.
N. E. Saxton (1999)
Toxicity of major histocompatibility complex class II specific monoclonal antibodies: audietur et altera pars.
I. Toral (1999)
Vaccination with peptides from MHC class II beta chain hypervariable region causes allele-specific suppression of EAE
J. Bright (1996)
Down‐regulation of class II major histocompatibility complex molecules on antigen‐presenting cells by antibody fragments
D. Vidović (1995)
Cytokine dysregulation and the initiation of systemic autoimmunity.
D. Hartwell (1994)
Monoclonal antibodies: probes for studying experimental autoimmunity in animals.
C. Boitard (1991)
Experimental immunoprevention of type I diabetes mellitus.
C. Boitard (1991)
Treatment of autoimmune diseases with antibodies to class II major histocompatibility complex antigens.
A. Vladutiu (1991)
Role of the first external domain of I-A beta chain in immune responses and diabetes in non-obese diabetic (NOD) mice.
B. Singh (1990)
4 – Allelic Polymorphism of HLA Class II Antigens: Clues to the Molecular Basis of Autoimmunity
A. Sinha (1990)
Autoimmune diseases: the failure of self tolerance.
A. A. Sinha (1990)
Manipulation of the immune response by monoclonal antibodies in auto-immune pathology.
P. Benoit (1990)
Effects of anti-I-A and anti-I-E monoclonal antibodies on the induction and expression of experimental autoimmune thyroiditis in mice.
S. J. Stull (1990)
The T cell as a therapeutic target
I. Otterness (1989)
T CELL RECEPTORS IN
H. Acha-Orbea (1989)
Effects of in vivo administration of anti-Ia antibodies on contact sensitivity.
W. Aberer (1989)
In vivo effects of antibodies to immune response gene products. II. Suppression of humoral immune responses with monoclonal anti-I-A is due to suppressor cells.
N. Adelman (1988)
Therapy of Autoimmune Diseases with Monoclonal Antibodies to Class II Major Histocompatibility Complex Antigens: The Role of T Lymphocytes
C. Boitard (1988)
Anti-la antibody diminishes ocular inflammation in experimental autoimmune uveitis
Richard P. Wetzig (1988)
Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.
C. Boitard (1988)
Treatment of Experimental Autoimmune Myasthenia Gravis with Monoclonal Antibodies to Immune Response Gene Products a
M. Waldor (1987)
Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: critical importance of timing of treatment
A. Friedmann (1987)
Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response
D. Moskophidis (1987)
Immunomodulation of murine visceral leishmaniasis by administration of monoclonal anti‐Ia antibodies: differential effects of anti‐I‐A vs. anti‐I‐E antibodies
J. Blackwell (1987)
Antibodies to immune response gene products inhibit the IgM and IgG antibody response but not the development of resistance to Toxoplasma gondii.
S. Sharma (1986)
Ir gene expression on T cells: Effect of a monoclonal antibody directed against I region‐controlled determinants on T cells
J. Yagi (1986)
The Nephritogenic Immune Response and Renal Immunopathogenesis
M. Clayman (1986)See more