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Synthesis And Characterization Of Ultra-small Superparamagnetic Iron Oxide Nanoparticles Thinly Coated With Silica.

A. Bumb, M. Brechbiel, P. Choyke, L. Fugger, A. Eggeman, D. Prabhakaran, J. Hutchinson, P. Dobson
Published 2008 · Materials Science, Medicine

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Ultra-small superparamagnetic iron oxide nanoparticles (SPIOs) were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (~2nm) layers of silica. The particles have been characterized for size, diffraction pattern, surface charge, and magnetic properties. This rapid and economical synthesis has a number of industrial applications; however, the silica-coated particles have been optimized for use in medical applications as MR contrast agents, biosensors, DNA capturing, bioseparation and enzyme immobilization.
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