← Back to Search
The Preparation Of Size-controlled Functionalized Polymeric Nanoparticles In Micelles.
A. Vakurov, N. A. Pchelintsev, Jessica Forde, C. Ó'Fágáin, T. Gibson, P. Millner
Published 2009 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
The reverse micellar system of dioctyl-sulfosuccinate (AOT)/octane and toluene have been used as a template for polymerization of acrylamide (AA)/bisacrylamide (BAA)-based functionalized polymeric nanoparticles. Such nanoparticles are typically sized between 20 and 90 nm. They can be synthesized with different functional groups according to the monomers added to the polymerization mixture. In our experiments the nanoparticles carried amino and carboxyl groups following incorporation of allylamine (AAm) or methacrylic acid (MAA) monomers, respectively. The available amine or carboxyl groups can then be used for immobilization of enzymes or other biomolecules. These enzymes, subtilisin, laccase and lipase, were immobilized onto polyAA/BAA/MAA nanoparticles covalently after activating the MAA carboxylic groups with Woodward's K reagent. Non-covalent immobilization via electrostatic interaction was also performed.
This paper references
Activity and stability studies of ultrafine nanoencapsulated catalase and penicillinase
N. Munshi (1995)
Conducting polymeric nanoparticles synthesized in reverse micelles and their gas sensitivity based on quartz crystal microbalance
Yajie Yang (2007)
Development of a polymeric nanoparticulate drug delivery system. In vitro characterization of nanoparticles based on sugar-containing conjugates.
I. Kim (2002)
Size control of polymeric nanoparticles from polystyrene-b-poly(2-vinylpyridine)
Yoon-Hee Cho (2004)
pH-Sensitivity and pH-dependent structural change in polymeric nanoparticles of poly(vinyl sulfadimethoxine)–deoxycholic acid conjugate
K. Na (2006)
Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
I. Kim (2003)
Structure and properties of AOT reversed micelles as studied by the fluorescence probe technique
M. Hasegawa (1996)
Skin penetration and distribution of polymeric nanoparticles.
R. Alvarez-Román (2004)
Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract.
S. Sakuma (1999)
Reactive polymeric nanoparticles based on unconventional dextran derivatives
T. Heinze (2007)
Fabrication of polymeric particles composed of two-dimensionally self-assembled nanoparticles by use of a microporous film as a template
K. Tamaki (2008)
Size Modulation of Polymeric Nanoparticles under Controlled Dynamics of Microemulsion Droplets
Distribution of amines in water/AOT/n-hexane reverse micelles: influence of the amine chemical structure.
Lilian Zingaretti (2005)
DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination.
Arianna Castaldello (2006)
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
Physicochemical characteristics and doxorubicin-release behaviors of pH/temperature-sensitive polymeric nanoparticles
S. I. Kang (2003)
Facile preparation of pH-responsive gelatin-based core-shell polymeric nanoparticles at high concentrations via template polymerization
Y. Zhang (2007)
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
C. Reis (2006)
Reversed micelles of polymeric surfactants in nonpolar organic solvents. A new microheterogeneous medium for enzymatic reactions.
Y. Khmelnitsky (1992)
The use of biodegradable polymeric nanoparticles in combination with a low-pressure gene gun for transdermal DNA delivery.
Po-Wei Lee (2008)
Thermally responsive polymeric micellar nanoparticles self-assembled from cholesteryl end-capped random poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): synthesis, temperature-sensitivity, and morphologies.
Xue-Ming Liu (2003)
Core-shell type polymeric nanoparticles composed of poly(L-lactic acid) and poly(N-isopropylacrylamide).
I. Kim (2000)
This paper is referenced by
Development of polymeric nanoparticles showing tuneable pH-responsive precipitation
A. Vakurov (2012)
PEBBLE Nanosensors for Intracellular Imaging and Analysis of Free Calcium and Zinc.
D. Si (2011)
Magnetic mesoporous silica nanoparticles: fabrication and their laccase immobilization performance.
Feng Wang (2010)
NTA : Applications in drug delivery Part 5 of NTA
Preparation of polymeric nanoparticles using a new polymerizable surfactant
P. Bunio (2011)
Nanoparticulate Carriers of Anticancer Drugs and Therapeutics
Ignác Capek (2019)
Structure-activity relationships of Candida rugosa lipase immobilized on polylactic acid nanoparticles
L. Chronopoulou (2011)
Amphoteric nano-, micro-, and macrogels, membranes, and thin films
S. Kudaibergenov (2012)
Synthesis and characterization of latex nanoparticles using a visible-light photoinitiating system in reverse micelles
E. M. Arbeloa (2014)
A review on impedimetric immunosensors for pathogen and biomarker detection
J. Leva-Bueno (2020)
Visible light photopolymerization in BHDC reverse micelles. Laser flash photolysis study of the photoinitiating mechanism
G. Porcal (2013)
Orthogonally bifunctionalised polyacrylamide nanoparticles: a support for the assembly of multifunctional nanodevices.
F. Giuntini (2012)
Influence of Shell Thickness on the Colloidal Stability of Magnetic Core-Shell Particle Suspensions
F. Neville (2018)
Detection of Salmonella typhi utilizing bioconjugated fluorescent polymeric nanoparticles
S. Jain (2016)