← Back to Search
Lipid Nanocarriers (GeluPearl) Containing Amphiphilic Lipid Gelucire 50/13 As A Novel Stabilizer: Fabrication, Characterization And Evaluation For Oral Drug Delivery.
A. Date, N. Vador, Aarti Jagtap, M. Nagarsenker
Published 2011 · Medicine, Materials Science
Save to my Library
Download PDFAnalyze on Scholarcy
PURPOSE To evaluate the ability of Gelucire 50/13 (an amphiphilic lipid excipient) to act as a stabilizer for lipid nanocarriers such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) and to establish the ability of Gelucire 50/13 based lipid nanocarriers to improve oral delivery of hydrophobic drugs using repaglinide (RPG) as a model drug. METHODS The ability of Gelucire 50/13 to nanosize various solid lipids was evaluated. The ability of Gelucire 50/13 to yield NLC was evaluated by using Precirol ATO 5 as a model solid lipid and various liquid lipids (oils). Gelucire 50/13 based NLC (GeluPearl) were evaluated for their ability to improve the efficacy of RPG on oral administration in comparison to RPG tablets. The short term stability of RPG-GeluPearl was evaluated at 25 °C/60% RH. RESULTS Gelucire 50/13 could successfully yield SLN and NLC of various solid lipids, demonstrating its potential to act as a novel stabilizer. DSC studies indicated that Gelucire 50/13 interacts with Precirol ATO 5 and this interaction suppresses polymorphic transitions of both the components. RPG-GeluPearl exhibited significantly higher anti-diabetic activity compared to marketed RPG tablets. RPG-GeluPearl demonstrated good colloidal and chemical stability at the end of 1 month.
This paper references
In vivo and in vitro antioxidant activity of lipid based extract of Bacopa monniera Linn . compared to conventional extract and traditional preparation Eur
L Sathianarayanan (2010)
Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles.
T. Helgason (2009)
Evidence for Phospholipid Bilayer Formation in Solid Lipid Nanoparticles Formulated with Phospholipid and Triglyceride
H. Heiati (2004)
Solid-state characterization of nifedipine solid dispersions.
S. Vippagunta (2002)
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
R. Mueller (2002)
An investigation into the mechanism of dissolution rate enhancement of poorly water - soluble drugs from spray chilled gelucire 50 / 13 microspheres J
S Qi (2010)
Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations.
M. Uner (2004)
Stabilization and improved in vivo performance of 11 Nanotechnology
S LShimpi (2005)
Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives
Melike Üner (2007)
A novel calcium silicate based microspheres of repaglinide: in vivo investigations.
S. K. Jain (2006)
Solid lipid nanoparticles ( SLN ) of tretinoin : potential in topical delivery Int
A ShahK (2007)
Solid lipid nanoparticles prepared by solvent diffusion method in a nanoreactor system.
H. Yuan (2008)
Ultrasound emulsification: effect of ultrasonic and physicochemical properties on dispersed phase volume and droplet size.
S. Gaikwad (2008)
Preparation and evaluation of stealth Tashinone IIA-loaded solid lipid nanoparticles: Influence of Poloxamer 188 coating on phagocytic uptake.
W. Zhang (2008)
Solid lipid nanoparticles ( SLNs ) to improve oral bioavailability of poorly soluble
L Hu (2004)
Solid lipid extrusion of sustained release dosage forms.
C. Reitz (2007)
Pharmaceutical approach to HIV protease inhibitor atazanavir for bioavailability enhancement based on solid dispersion system.
K. Fukushima (2007)
Stabilization and Improved in Vivo Performance of Amorphous Etoricoxib using Gelucire 50/13
S. Shimpi (2005)
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
M. Muchow (2008)
Physical and thermal characterisation of Precirol and Compritol as lipophilic glycerides used for the preparation of controlledrelease matrix pellets Int
J Hamdani (2003)
Diclofenac salts, II. Solid dispersions in PEG6000 and Gelucire 50/13.
A. Fini (2005)
Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles
S. Martins (2007)
Solid lipid nanoparticles for parenteral drug delivery.
S. Wissing (2004)
An investigation into the mechanism of dissolution rate enhancement of poorly water-soluble drugs from spray chilled gelucire 50/13 microspheres.
S. Qi (2010)
Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the alpha-modification.
K. Rosenblatt (2009)
Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery.
Kumar A. Shah (2007)
Design, optimization, preparation and evaluation of dispersion granules of valsartan and formulation into tablets.
A. R. Shrivastava (2009)
Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC.
Veerawat Teeranachaideekul (2008)
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
J. Pardeike (2009)
Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs
L. Hu (2004)
Enhancing effect of Labrafac Lipophile WL 1349 on oral bioavailability of hydroxysafflor yellow A in rats.
S. Wang (2008)
Poly ( vinyl alcohol ) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the αmodification Mol
M RosenblattK (2009)
Activity of water-soluble turmeric extract using hydrophilic excipients
S. Gilda (2010)
Cefuroxime axetil solid dispersion with polyglycolized glycerides for improved stability and bioavailability
R. Dhumal (2009)
Solid lipid nanoparticles prepared by solvent diffusion method in a nanoreactor system Colloids Surf
H Yuan (2008)
Functional Relationship between Volume Concentration of Dispersed Phase and Relative Viscosity in a Liquid-Liquid Dispersion and Emulsion
Physical and thermal characterisation of Precirol and Compritol as lipophilic glycerides used for the preparation of controlled-release matrix pellets.
J. Hamdani (2003)
In vivo and in vitro antioxidant activity of lipid based extract of Bacopa monniera Linn. compared to conventional extract and traditional preparation
L. Sathiyanarayanan (2010)
This paper is referenced by
Glutathione-loaded solid lipid nanoparticles based on Gelucire® 50/13: Spectroscopic characterization and interactions with fish cells
A. Trapani (2018)
Near-infrared mediated quantum dots and paclitaxel co-loaded nanostructured lipid carriers for cancer theragnostic.
L. Olerile (2017)
Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.
Daniel Wehrung (2012)
Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation.
V. Dhawan (2020)
Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles.
D. Codoni (2015)
Single-step and low-energy method to prepare solid lipid nanoparticles and nanostructured lipid carriers using biocompatible solvents
A. Date (2019)
Self-Assembled Lipid Nanoparticles for Oral Delivery of Heparin-Coated Iron Oxide Nanoparticles for Theranostic Purposes
Eleonora Truzzi (2017)
Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting.
Ming-Jun Tsai (2012)
Self-Nanoemulsifying Lyophilized Tablets for Flash Oral Transmucosal Delivery of Vitamin K: Development and Clinical Evaluation.
K. El-Say (2017)
Supercritical Fluid Technology-Based Trans-Resveratrol SLN for Long Circulation and Improved Radioprotection
I. Ahmad (2016)
Nanostructure Lipid Carrier (NLC): the new generation of lipid nanoparticles
Sarabjot Kaur (2015)
Solid lipid nanoparticles made of self-emulsifying lipids for efficient encapsulation of hydrophilic substances
A. Trapani (2019)
Glutathione loaded solid lipid nanoparticles: Preparation and in vitro evaluation as delivery systems of the antioxidant peptide to immunocompetent fish cells
A. Trapani (2016)
DEVELOPMENT AND IN VITRO EVALUATION OF NANOSTRUCTURED LIPID CARRIERS (NLCs) OF GLICLAZIDE
Aindrilla S Duttagupta (2016)
Enhanced Oral Absorption of Amisulpride Via a Nanostructured Lipid Carrier-Based Capsules: Development, Optimization Applying the Desirability Function Approach and In Vivo Pharmacokinetic Study
Abd El-Halim I. El Assasy (2019)
Quality by Design Approach for Preparation of Zolmitriptan/Chitosan Nanostructured Lipid Carrier Particles – Formulation and Pharmacodynamic Assessment
Randa Hanie Awadeen (2020)
Optimization of nanostructured lipid carriers: understanding the types, designs, and parameters in the process of formulations
B. Subramaniam (2020)
Development and physical characterisation of polyethylene glycol glycerides-based gel formulations for macromolecule delivery
D. Codoni (2013)
Nanostructured lipid carriers: versatile oral delivery vehicle
Neelam Poonia (2016)
Tacrolimus-loaded lecithin-based nanostructured lipid carrier and nanoemulsion with propylene glycol monocaprylate as a liquid lipid: formulation characterization and assessment of dermal delivery compared to referent ointment.
V. Savić (2019)
Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin
Mirza Salman Baig (2020)
Fabrication of an Ion-sensitive in situ Gel loaded with Nanostructured Lipid Carrier for Nose to Brain Delivery of Donepezil
Shital B Butani (2019)
Nanostructured lipid carriers (NLCs) for drug delivery and targeting.
C. Fang (2013)
Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
M. Haider (2020)
The influence of different nanocarriers on skin’s biophysical parameters
Sara Catarina Henriques Andrade (2017)
Promoted Antitumor Activity of Myricetin against Lung Carcinoma Via Nanoencapsulated Phospholipid Complex in Respirable Microparticles
N. Nafee (2020)
Solid Lipid Nanoparticles as Formulative Strategy to Increase Oral Permeation of a Molecule Active in Multidrug-Resistant Tuberculosis Management
Antonella Obinu (2020)
Gelucire-Based Nanoparticles for Curcumin Targeting to Oral Mucosa: Preparation, Characterization, and Antimicrobial Activity Assessment.
Heba A Hazzah (2015)
Formulation and ex vivo Evaluation of Solid Lipid Nanoparticles (SLNS) Based Hydrogel for Intranasal Drug Delivery
P. Jagtap (2015)
P. Nazemi (2017)
Physicochemical and pharmacodynamic evaluation of pioglitazone binary systems with hydrophilic carriers
M. Ibrahim (2019)
Gelucire-stabilized nanoparticles as a potential DNA delivery system
M. Oyewumi (2016)See more