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The Applications Of Nano-medicine In The Breast Cancer Therapy

N A Saeed, I H Hamzah, S I Mahmood

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Abstract Breast cancer (BC) is the commonest malignancy in women worldwide. Triple-negative breast cancer (TNBC) with three main-receptors which is estrogen-receptor, progesterone-receptor, and human-epidermal-growth factor receptor-2, Absent hormonal-receptor in cells of breast cancer familiar to expression an aggressive phenotypes as well as increasing the metastasis that leading to develop the resistance for chemotherapies. Different types of treatment and therapies currently can stop the spreading of BC and TNBC but with side-effects for healthy cells or tissues. Nanotechnologies present many unique efficient alternatives to designs and synthesis of small-size nanomaterial which target both active and passive and can be used to attached multi-targeting moiety by controlled cellular uptakes with a minimum amount of nanometric carriers. Which are able to carry drug, tracking-probes, and ligands, designing on same pathway, which specifically targets each cell of BC on sites. Indicating the targeted deliver-system by highly functional molecules with multi specificity, tracking, diagnosing, and treating emerge as theranostic-approach. Particularly, carbon nanomaterial such as fullerenes, nanotube and graphenes, is scientific interesting regarding the chemical functions, biological and physical characteristics. The latest scientific guide offers the possibility usage of carbon nanomaterial to be a therapeutically factors, Systematic agents to control drug releasing as well as contracting factors to diagnostic the tumor. producing new potentials to developing innovatively orders to detecting BC on the beginning and treatment period. In this review, we shed the light on traditional drugs therapy, unique therapy to providing the current nanotechnology applied for approaching metastatic BC treatment and diagnosing by using carbon nanomaterials.