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Symptom Frequency And Severity In Patients With Metastatic Or Locally Recurrent Lung Cancer: A Prospective Study Using The Lung Cancer Symptom Scale In A Community Hospital.

S. Lutz, R. Norrell, C. Bertucio, L. Kachnic, C. Johnson, D. Arthur, M. Schwarz, G. Palardy
Published 2001 · Medicine

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PURPOSE To define symptoms and therapeutic requirements for patients with metastatic or locally recurrent lung cancer. METHODS AND MATERIALS Data were collected from 69 consecutive patients with locally advanced lung cancer seen in consultation at a radiation oncology facility serving a community hospital in Virginia. The Lung Cancer Symptom Scale, a validated quality of life instrument, measured the incidence of symptoms in this group. RESULTS Average survival for the entire group was 7 months. Fifty-seven patients received 81 courses of radiation therapy, 33 directed at thoracic disease and 48 delivered to sites of metastasis. Thirty-three percent of those who received radiation therapy required treatment to more than one anatomic site. Every patient was symptomatic at the time of consultation, with the number (p = 0.001) and severity (p = 0.001) of symptoms they suffered worse in the patient group seen 0 to 3 months prior to death rather than 4 to 6 months prior to death. With the exception of cough, symptoms were marked in their severity. CONCLUSIONS Patients with advanced lung cancer suffer frequent and severe symptoms that worsen in the final months of life. The appropriate timing and combination of radiotherapy and chemotherapy are yet to be resolved. Future studies will require use of validated quality of life instruments to better catalogue palliation and treatment toxicity.
This paper references
Non-small cell lung cancer. Part I: Biology, diagnosis, and staging.
D. Ihde (1991)
Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. The Elderly Lung Cancer Vinorelbine Italian Study Group.
C. Gridelli (1999)
A dilemma in analysis: issues in the serial measurement of quality of life in patients with advanced lung cancer.
P. Hollen (1997)
The validity and clinical utility of symptom monitoring in advanced lung cancer: a literature review.
M. Soni (2002)
Comparison of instruments for measuring quality of life in patients with lung cancer.
P. Hollen (1996)
Locally advanced non-small cell lung cancer: do we know the questions? A survey of randomized trials from 1966-1993.
M. Brundage (1996)
Toxicity, physical function and everyday activity reported by patients with inoperable non-small cell lung cancer in a randomized trial (chemotherapy versus radiotherapy).
S. Kaasa (1988)
A retrospective quality of life analysis using the Lung Cancer Symptom Scale in patients treated with palliative radiotherapy for advanced nonsmall cell lung cancer.
S. Lutz (1997)
Normative data and trends in quality of life from the Lung Cancer Symptom Scale (LCSS)
P. Hollen (1999)
Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer.
M. J. Matthews (1973)
Frequency and prognostic importance of pretreatment clinical characteristics in patients with advanced non-small-cell lung cancer treated with combination chemotherapy.
J. O'connell (1986)
A Medical Research Council (MRC) randomised trial of palliative radiotherapy with two fractions or a single fraction in patients with inoperable non-small-cell lung cancer (NSCLC) and poor performance status. Medical Research Council Lung Cancer Working Party.
N. Bleehen (1992)
Hospice lengths of stay dwindling.
A. Saphir (1999)
Staging and prognostic factors in small cell carcinoma of the lung.
K. Osterlind (1983)
Measurement of quality of life in patients with lung cancer in multicenter trials of new therapies. Psychometric assessment of the lung cancer symptom scale
P. Hollen (1994)
Survival of Medicare patients after enrollment in hospice programs.
N. Christakis (1996)
A randomized study on palliative radiation therapy for inoperable non small cell carcinoma of the lung.
P. Teo (1988)
Quality of life assessment in individuals with lung cancer: testing the Lung Cancer Symptom Scale (LCSS).
P. Hollen (1993)
Prognostic implications of the International Staging System for Lung Cancer.
C. Mountain (1988)
Quality of life end points in cancer clinical trials: review and recommendations.
C. Moinpour (1989)
National cancer institute sponsored cooperative clinical trials
M. Friedman (1990)
Quality of life and survival in patients with advanced non-small cell lung cancer receiving supportive care plus chemotherapy with carboplatin and etoposide or supportive care only. A multicentre randomised phase III trial. Joint Lung Cancer Study Group.
M. Helsing (1998)
Small-cell carcinoma of the lung: derivation of a prognostic staging system.
U. Sagman (1991)
Food and Drug Administration requirements for approval of new anticancer drugs.
J. Johnson (1985)
Palliative radiotherapy for inoperable carcinoma of the lung: final report of a RTOG multi-institutional trial.
J. M. Simpson (1985)

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Implementation of optimized supportive care and hospital needs along the management of patients with advanced lung cancer.
Claire Lafitte (2018)
Lung cancer on Haugalandet, Norway
K. Skaug (2012)
Comprehensive management of respiratory symptoms in patients with advanced lung cancer.
Jessica B. McCannon (2012)
The meaning and significance of routine follow-up in lung cancer - a qualitative study of patients' experiences and interpretations.
G. Sandeman (2011)
H. Gürses (2015)
A brief symptom index for advanced lung cancer.
S. Yount (2012)
Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer: results of a randomized study of early palliative care.
J. Temel (2011)
Motivo de consulta en el diagnóstico de cáncer de pulmón. Revisión de 481 casos
I. V. Cajoto (2009)
Integrating Palliative Medicine into Comprehensive Breast Cancer Therapy – a Pilot Project
J. Gaertner (2011)
Early palliative care for patients with metastatic non-small-cell lung cancer.
J. Temel (2010)
Pilot Study of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer.
J. Greer (2015)
End-of-Life Care for People With Cancer From Ethnic Minority Groups
M. LoPresti (2016)
Dyspnoea in advanced disease : a guide to clinical management
S. Booth (2006)
The validity and clinical utility of symptom monitoring in advanced lung cancer: a literature review.
M. Soni (2002)
The relationship between fibromyalgia symptoms and physical function in middle-aged and older adults
C. Shillam (2008)
Oncological and Palliative Care for Patients with Lung Cancer and Patients with Breast Cancer: Two Opposite Ends of a Spectrum
Norbert Frickhofen (2015)
Utilization of supportive and palliative care services among oncology outpatients at one academic cancer center: determinants of use and barriers to access.
Pallavi Kumar (2012)
How should we design supportive cancer care? The patient's perspective.
D. Casarett (2008)
Prognostic Factors in Non-Small Cell Lung Cancer (NSCLC)
Georg Holgersson (2017)
Palliative care units in lung cancer in the real-world setting: a single institution's experience and its implications.
E. Masel (2017)
Effects of exercise training programs on physical performance and quality of life in patients with metastatic lung cancer undergoing palliative chemotherapy--a study protocol.
W. Jensen (2014)
Correction to: Can early palliative care with anticancer treatment improve overall survival and patient-related outcomes in advanced lung cancer patients? A review of the literature
M. Ambroggi (2018)
Perceptions of health status and survival in patients with metastatic lung cancer.
J. Greer (2014)
The Relationships Among Pain, Dyspnea, Constipation and Quality of Life in Lung Cancer Patients Enrolled in a Hospice Program
Lisa A. Laches (2007)
The emerging role of palliative medicine in the treatment of lung cancer patients
M. Davis (2012)
Palliative External Beam Thoracic Radiation Therapy of Non-Small Cell Lung Cancer
Stein H Sundstrøm (2011)
Symptom prevalence in patients with incurable cancer: a systematic review.
S. Teunissen (2007)
Photodynamic therapy for the treatment of non-small cell lung cancer.
C. Simone (2012)
Symptom assessment in patients with advanced lung cancer at the in-patient palliative care unit and at home palliative care
W. Leppert (2010)
Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer.
J. Greer (2012)
Prevalence and predictors of symptoms in the terminal stage of lung cancer: A community study.
K. Skaug (2007)
Quality of Life in Patients With Advanced Lung Cancer Treated at Home and at a Palliative Care Unit
W. Leppert (2012)
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