Online citations, reference lists, and bibliographies.

Biomechanical Evaluation Of An Injectable And Biodegradable Copolymer P(PF-co-CL) In A Cadaveric Vertebral Body Defect Model.

Z. Fang, H. Giambini, H. Zeng, J. Camp, M. Dadsetan, R. Robb, K. An, M. Yaszemski, L. Lu
Published 2014 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
A novel biodegradable copolymer, poly(propylene fumarate-co-caprolactone) [P(PF-co-CL)], has been developed in our laboratory as an injectable scaffold for bone defect repair. In the current study, we evaluated the ability of P(PF-co-CL) to reconstitute the load-bearing capacity of vertebral bodies with lytic lesions. Forty vertebral bodies from four fresh-frozen cadaveric thoracolumbar spines were used for this study. They were randomly divided into four groups: intact vertebral body (intact control), simulated defect without treatment (negative control), defect treated with P(PF-co-CL) (copolymer group), and defect treated with poly(methyl methacrylate) (PMMA group). Simulated metastatic lytic defects were made by removing a central core of the trabecular bone in each vertebral body with an approximate volume of 25% through an access hole in the side of the vertebrae. Defects were then filled by injecting either P(PF-co-CL) or PMMA in situ crosslinkable formulations. After the spines were imaged with quantitative computerized tomography, single vertebral body segments were harvested for mechanical testing. Specimens were compressed until failure or to 25% reduction in body height and ultimate strength and elastic modulus of each specimen were then calculated from the force-displacement data. The average failure strength of the copolymer group was 1.83 times stronger than the untreated negative group and it closely matched the intact vertebral bodies (intact control). The PMMA-treated vertebrae, however, had a failure strength 1.64 times larger compared with the intact control. The elastic modulus followed the same trend. This modulus mismatch between PMMA-treated vertebrae and the host vertebrae could potentially induce a fracture cascade and degenerative changes in adjacent intervertebral discs. In contrast, P(PF-co-CL) restored the mechanical properties of the treated segments similar to the normal, intact, vertebrae. Therefore, P(PF-co-CL) may be a suitable alternative to PMMA for vertebroplasty treatment of vertebral bodies with lytic defects.
This paper references
10.1016/S0021-9290(01)00086-0
Parametric finite element analysis of vertebral bodies affected by tumors.
C. Whyne (2001)
New fractures after vertebroplasty: adjacent fractures occur significantly sooner.
A. Trout (2006)
10.1097/01.brs.0000260979.98101.9c
Quantitative Computed Tomography-Based Predictions of Vertebral Strength in Anterior Bending
J. Buckley (2007)
10.1007/s00234-002-0856-1
Percutaneous vertebroplasty: long-term clinical and radiological outcome
A. Pérez-Higueras (2002)
10.1097/01.BRS.0000051910.97211.BA
Burst Fracture in the Metastatically Involved Spine: Development, Validation, and Parametric Analysis of a Three-Dimensional Poroelastic Finite-Element Model
C. Whyne (2003)
10.1021/MA050884C
A Biodegradable and Cross-Linkable Multiblock Copolymer Consisting of Poly(propylene fumarate) and Poly(ε-caprolactone): Synthesis, Characterization, and Physical Properties
Shanfeng Wang (2005)
10.1097/00007632-199001000-00001
Spinal Metastases: The Obvious, the Occult, and the Impostors
D. Wong (1990)
10.1016/S8756-3282(99)00127-1
Temperature elevation caused by bone cement polymerization during vertebroplasty.
H. Deramond (1999)
10.1016/j.jbiomech.2010.04.023
A nonlinear finite element model validation study based on a novel experimental technique for inducing anterior wedge-shape fractures in human vertebral bodies in vitro.
E. Dallara (2010)
10.1097/SPC.0b013e32833d2fdd
Management of metastatic spine disease
Mohammed Eleraky (2010)
10.1097/00007632-200005010-00002
Vertebroplasty: an opportunity to do something really good for patients.
T. Einhorn (2000)
10.1021/bm1008102
Distinct cell responses to substrates consisting of poly(ε-caprolactone) and poly(propylene fumarate) in the presence or absence of cross-links.
K. Wang (2010)
10.1097/BRS.0b013e3181ac8f07
Repeated and Multiple New Vertebral Compression Fractures After Percutaneous Transpedicular Vertebroplasty
Yuan-Yun Tseng (2009)
10.1016/J.BIOMATERIALS.2005.07.013
Synthesis and characterizations of biodegradable and crosslinkable poly(epsilon-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer.
Shanfeng Wang (2006)
10.1097/01.bsd.0000172362.15103.e8
Stability of the Metastatic Spine Pre and Post Vertebroplasty
H. Ahn (2006)
Does vertebroplasty cause incident vertebral fractures? A review of available data.
A. Trout (2006)
10.1243/09544119H00305
The Biomechanical Effect of Vertebroplasty on the Adjacent Vertebral Body: A Finite Element Study
R. Wilcox (2006)
10.1097/BSD.0b013e3182213f57
Evaluation of Calcium Phosphate and Calcium Sulfate as Injectable Bone Cements in Sheep Vertebrae
X. Zhu (2012)
10.1097/00024720-200304000-00010
Biomechanically Derived Guideline Equations for Burst Fracture Risk Prediction in the Metastatically Involved Spine
C. Whyne (2003)
development, validation, and parametric analysis of a three-dimensional poroelastic finiteelement model
C. M. Whyne (1976)
10.1016/S8756-3282(03)00210-2
Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography.
R. Crawford (2003)
cement polymerization during vertebroplasty
T. A. Einhorn (1999)
10.1097/01.BRS.0000076829.54235.9F
Temperature Measurement During Polymerization of Polymethylmethacrylate Cement Used for Vertebroplasty
S. Belkoff (2003)
Subsequent vertebral fractures after vertebroplasty: association with intraosseous clefts.
A. Trout (2006)
10.1097/BRS.0b013e3181714a84
Calcium-Phosphate and Polymethylmethacrylate Cement in Long-term Outcome After Kyphoplasty of Painful Osteoporotic Vertebral Fractures
I. Grafe (2008)
10.3174/ajnr.A1269
Frequency and Outcome of Pulmonary Polymethylmethacrylate Embolism during Percutaneous Vertebroplasty
A. Venmans (2008)
[Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty].
P. Galibert (1987)
10.3322/CANJCLIN.43.1.7
Cancer statistics, 1993
C. Boring (1993)
10.1097/00007632-200301150-00006
Micro-Computed Tomography Evaluation of Trabecular Bone Structure on Loaded Mice Tail Vertebrae
A. Issever (2003)
10.1097/BRS.0b013e3181c9f7fc
Feasibility Study of Using Viscoplastic Bone Cement for Vertebroplasty: An In Vivo Clinical Trial and In Vitro Cadaveric Biomechanical Examination
Shih-Wei Lin (2010)
10.1016/j.ctrv.2012.08.002
Current and emerging concepts in non-invasive and minimally invasive management of spine metastasis.
A. Bhatt (2013)
10.1163/092050610X487765
Cross-linking Characteristics and Mechanical Properties of an Injectable Biomaterial Composed of Polypropylene Fumarate and Polycaprolactone Co-polymer
Jun Yan (2011)
10.1097/01.BRS.0000076831.38265.8D
The Effect of Vertebral Body Percentage Fill on Mechanical Behavior During Percutaneous Vertebroplasty
S. Molloy (2003)
10.1007/s00586-013-2908-0
Biomechanical comparison of vertebral augmentation with silicone and PMMA cement and two filling grades
T. Schulte (2013)
10.1007/s10067-004-0914-7
Long-term follow-up of vertebral osteoporotic fractures treated by percutaneous vertebroplasty
I. Legroux-Gérot (2004)
10.1097/BRS.0b013e3181b61d10
Vertebroplasty With High-Viscosity Polymethylmethacrylate Cement Facilitates Vertebral Body Restoration In Vitro
M. Rüger (2009)
10.1021/bm7012313
Photo-cross-linked hybrid polymer networks consisting of poly(propylene fumarate) and poly(caprolactone fumarate): controlled physical properties and regulated bone and nerve cell responses.
Shanfeng Wang (2008)
10.2106/00004623-200406000-00016
Histologic changes after vertebroplasty.
J. Verlaan (2004)
10.1016/J.SPINEE.2005.02.020
Vertebroplasty and kyphoplasty: filler materials.
I. Lieberman (2005)



This paper is referenced by
10.1089/ten.TEC.2016.0078
Noninvasive Failure Load Prediction of Vertebrae with Simulated Lytic Defects and Biomaterial Augmentation.
H. Giambini (2016)
10.1016/B978-1-78242-087-3.00001-8
Material types for tissue scaffolds
P E Tomlins (2016)
10.1007/s11517-015-1348-x
Specimen-specific vertebral fracture modeling: a feasibility study using the extended finite element method
H. Giambini (2015)
10.1021/ACSMACROLETT.6B00736
Poly(ε-caprolactone) Dendrimer Cross-Linked via Metal-Free Click Chemistry: Injectable Hydrophobic Platform for Tissue Engineering
Xifeng Liu (2016)
10.3390/polym9070260
Tissue Engineering Bionanocomposites Based on Poly(propylene fumarate)
Ana María Díez-Pascual (2017)
10.1097/BRS.0000000000000540
Specimen-Specific Nonlinear Finite Element Modeling to Predict Vertebrae Fracture Loads After Vertebroplasty
Y. Matsuura (2014)
10.1089/ten.TEA.2016.0246
A New Vertebral Body Replacement Strategy Using Expandable Polymeric Cages.
Xifeng Liu (2017)
10.1016/j.biomaterials.2019.03.038
Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications.
Z. Cai (2019)
10.1016/j.medengphy.2017.11.007
Inducing targeted failure in cadaveric testing of 3-segment spinal units with and without simulated metastases.
Karlijn H J Groenen (2018)
10.1080/10790268.2018.1432309
A 3D finite element model of prophylactic vertebroplasty in the metastatic spine: Vertebral stability and stress distribution on adjacent vertebrae
A. Berton (2018)
10.1016/j.jmbbm.2019.103399
Mechanical testing setups affect spine segment fracture outcomes.
A. Rezaei (2019)
Semantic Scholar Logo Some data provided by SemanticScholar