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Injectable Pore-Forming Hydrogel Scaffolds For Complex Wound Tissue Engineering: Designing And Controlling Their Porosity And Mechanical Properties.
Robert M T Staruch, G. Glass, R. Rickard, S. Hettiaratchy, P. Butler
Published 2017 · Materials Science, Medicine, Biology
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Traumatic soft tissue wounds present a significant reconstructive challenge. The adoption of closed-circuit negative pressure wound therapy (NPWT) has enabled surgeons to temporize these wounds before reconstruction. Such systems use porous synthetic foam scaffolds as wound fillers at the interface between the negative pressure system and the wound bed. The idea of using a bespoke porous biomaterial that enhances wound healing, as filler for an NPWT system, is attractive as it circumvents concerns regarding reconstructive delay and the need for dressing changes that are features of the current systems. Porous foam biomaterials are mechanically robust and able to synthesize in situ. Hence, they exhibit potential to fulfill the niche for such a functionalized injectable material. Injectable scaffolds are currently in use for minimally invasive surgery, but the design parameters for large-volume expansive foams remain unclear. Potential platforms include hydrogel systems, (particularly superabsorbent, superporous, and nanocomposite systems), polyurethane-based moisture-cured foams, and high internal phase emulsion polymer systems. The aim of this review is to discuss the design parameters for such future biomaterials and review potential candidate materials for further research into this up and coming field.
This paper references
Surface characterization and in vitro platelet compatibility study of surface sulfonated chitosan membrane with amino group protection–deprotection strategy
Hsi-Yi Yeh (2008)
Versatile click alginate hydrogels crosslinked via tetrazine-norbornene chemistry.
Rajiv M Desai (2015)
A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing.
C. Gong (2013)
A novel design of injectable porous hydrogels with in situ pore formation.
O. Yom-Tov (2014)
The debridement of chronic wounds: a systematic review.
M. Bradley (1999)
Limb Salvage of Severely Injured Extremities After Military Wounds
K. Brown (2011)
Control of cell attachment on pH-responsive chitosan surface by precise adjustment of medium pH.
Yi-Hsin Chen (2012)
The structural and magnetic properties of gadolinium doped CoFe 2 O 4 nanoferrites
Qing Lin (2015)
Injectable, spontaneously assembling inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
J. Kim (2015)
Three-dimensional biomaterial degradation - Material choice, design and extrinsic factor considerations.
L. Yildirimer (2014)
Biological response of hydrogels embedding gold nanoparticles.
E. Marsich (2011)
Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics
M. Lutolf (2003)
Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering.
JunMin Zhu (2010)
Degradation behavior of covalently cross-linked poly(aldehyde guluronate) hydrogels
K. Lee (2000)
Mechanosignaling in bone health, trauma and inflammation.
D. Knapik (2014)
Effect of negative pressure wound therapy on wound healing.
C. Huang (2014)
Does a Zone of Increased Perfusion Exist around Negative-Pressure Dressings?
N. Kairinos (2013)
Effects of negative pressure wound therapy on fibroblast viability, chemotactic signaling, and proliferation in a provisional wound (fibrin) matrix
Amy K. Mcnulty (2007)
Biomimetic hydrogel with tunable mechanical properties for vitreous substitutes.
S. Santhanam (2016)
Injectable cationic hydrogels with high antibacterial activity and low toxicity
H. Du (2016)
Introducing an innovation in NPWT for acute care settings.
S. Jeffery (2012)
Green synthesis and nanotopography of heparin-reduced gold nanoparticles with enhanced anticoagulant activity.
H. Kim (2013)
Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture.
K. Whang (1999)
The influence of the RGD peptide motif and its contextual presentation in PEG gels on human mesenchymal stem cell viability
C. N. Salinas (2008)
Controlled degradation of hydrogels using multi-functional cross-linking molecules.
K. Lee (2004)
Swelling characteristics of thermo‐ sensitive poly[(2‐diethylaminoethyl methacrylate)‐co‐(N,N‐dimethylacrylamide)] porous hydrogels
T. Çaykara (2007)
Template for Skin Regeneration
I. Yannas (2011)
Effects of vacuum‐assisted closure therapy on inguinal wound edge microvascular blood flow
A. Wackenfors (2004)
Interplay of biomaterials and micro-scale technologies for advancing biomedical applications
A. Khademhosseini (2006)
Novel injectable biodegradable glycol chitosan-based hydrogels crosslinked by Michael-type addition reaction with oligo(acryloyl carbonate)-b-poly(ethylene glycol)-b-oligo(acryloyl carbonate) copolymers.
Yuexin Yu (2011)
Influence of cure conditions on the properties of a one-component moisture-cured polyurethane adhesive in the context of green gluing of wood
Magdalena Sterley (2012)
The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells.
Akhilesh Banerjee (2009)
Tough Bonding of Hydrogels to Diverse Nonporous Surfaces
Hyunwoo Yuk (2016)
Contemporary Approaches To Definitive Extremity Reconstruction Of Military Wounds
C. J. Taylor (2009)
Dressings for acute and chronic wounds: a systematic review.
G. Chaby (2007)
Negative‐pressure wound therapy using gauze or open‐cell polyurethane foam: Similar early effects on pressure transduction and tissue contraction in an experimental porcine wound model
M. Malmsjö (2009)
Endothelialized microvasculature based on a biodegradable elastomer.
Christina Fidkowski (2005)
Injectable, interconnected, high-porosity macroporous biocompatible gelatin scaffolds made by surfactant-free emulsion templating.
B. H. L. Oh (2015)
Enhanced Swelling Rate of Poly(ethylene glycol)-Grafted Superporous Hydrogels
K. Huh (2005)
Synthesis of emulsion-templated poly(acrylamide) using CO2-in-water emulsions and poly(vinyl acetate)-based block copolymer surfactants
B. Tan (2007)
Mechanical analysis of Nanocomposite Bipolymer Hydrogel Foams for military wound healing
YL Staruch RMT (2015)
Porous methacrylate scaffolds: supercritical fluid fabrication and in vitro chondrocyte responses.
J. J. Barry (2004)
Pushing back: wound mechanotransduction in repair and regeneration.
V. Wong (2011)
Putting the fizz into chemistry: applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers.
H. Tai (2007)
Alginate‐Encapsulation for the Improved Hypothermic Preservation of Human Adipose‐Derived Stem Cells
S. Swioklo (2016)
Thermosensitive chitosan-Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration.
K. Park (2009)
Hydrogel dressings in the management of a variety of wound types: A review
A. M. Jones (2005)
The Influence Manufacturers Have on Negative-Pressure Wound Therapy Research
N. Kairinos (2014)
Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
Craig S Nowell (2016)
Applications of Supercritical Fluid in Alloplastic Bone Graft: A Novel Method and in Vitro Tests
C. F. Chen (2006)
Matrix Control of Stem Cell Fate
S. Even-Ram (2006)
Photocrosslinkable polysaccharides for in situ hydrogel formation.
K. Smeds (2001)
Composite Hydrogels with Tunable Anisotropic Morphologies and Mechanical Properties
Mokit Chau (2016)
Moving from static to dynamic complexity in hydrogel design.
J. Burdick (2012)
Light-activated hydrogel formation via the triggered folding and self-assembly of a designed peptide.
L. Haines (2005)
In vitro antimicrobial activity of calcium sulfate and hydroxyapatite (Cerament Bone Void Filler) discs using heat-sensitive and non-heat-sensitive antibiotics against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
J. Karr (2011)
Introduction to cell–hydrogel mechanosensing
Mark Ahearne (2014)
Wound repair and regeneration
G. Gurtner (2008)
Polymeric calcium phosphate cements: setting reaction modifiers.
K. Miyazaki (1993)
Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice.
K. Obara (2003)
Polyurethane scaffold with in situ swelling capacity for nucleus pulposus replacement.
Z. Li (2016)
Design of a thermosensitive bioglass/agarose-alginate composite hydrogel for chronic wound healing.
Qiongyu Zeng (2015)
Mechanobiology and developmental control.
T. Mammoto (2013)
Cell Attachment–Detachment Control on Temperature-Responsive Thin Surfaces for Novel Tissue Engineering
Y. Kumashiro (2010)
Substrate modulus directs neural stem cell behavior.
K. Saha (2008)
Mechanosensitive mechanisms in transcriptional regulation
A. Mammoto (2012)
Matrix Elasticity Directs Stem Cell Lineage Specification
A. Engler (2006)
Supercritical fluid technologies and tissue engineering scaffolds
R. Quirk (2004)
"Supercritical carbon dioxide in water" emulsion-templated synthesis of porous calcium alginate hydrogels
S. Partap (2006)
Introduction of gelatin microspheres into an injectable calcium phosphate cement.
W. Habraken (2008)
The influence of substrate stiffness gradients on primary human dermal fibroblasts.
I. Hopp (2013)
Matrix Elasticity of Void-Forming Hydrogels Controls Transplanted Stem Cell-Mediated Bone Formation
Nathaniel Huebsch (2015)
Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine.
B. Kheirabadi (2009)
Soft tissue mechanotransduction in wound healing and fibrosis.
V. Wong (2012)
Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: Dose finding study
M. Peev (2014)
A computational skin model: fold and wrinkle formation
N. Magnenat-Thalmann (2002)
Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks.
D. Griffin (2015)
Synthesis of thermal polymerizable Alginate-GMA hydrogel for cell encapsulation
X. Wang (2015)
Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds.
M. Bradley (1999)
Hydrostatic pressure promotes the proliferation and osteogenic/chondrogenic differentiation of mesenchymal stem cells: The roles of RhoA and Rac1.
Yin-Hua Zhao (2015)
Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal model
M. Januszyk (2014)
Response of Sheep Chondrocytes to Changes in Substrate Stiffness from 2 to 20 Pa: Effect of Cell Passaging
P. Sanz-Ramos (2013)
Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation.
D. Benoit (2005)
Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model.
C. D. Hermann (2014)
Therapeutic application of injectable thermosensitive hydrogel in preventing local breast cancer recurrence and improving incision wound healing in a mouse model.
N. Lei (2012)
Effect of calcium ions on transformation brushite to hydroxyapatite in aqueous solutions
R. Štulajterová (2008)
Biomechanical properties of dermis.
C. Daly (1982)
Injectable cryogel-based whole-cell cancer vaccines.
S. Bencherif (2015)
In vivo renal clearance, biodistribution, toxicity of gold nanoclusters.
X. Zhang (2012)
New processing approaches in calcium phosphate cements and their applications in regenerative medicine.
M. Ginebra (2010)
Stem cells: Imaging the origin of HSCs
R. David (2010)
Electrical pulsed stimulation of surfaces homogeneously coated with gold nanoparticles to induce neurite outgrowth of PC12 cells.
J. Park (2009)
Injectable, porous, and cell-responsive gelatin cryogels.
Sandeep T. Koshy (2014)
Chitosan-PEG hydrogel with sol-gel transition triggerable by multiple external stimuli.
C. T. Tsao (2015)
Wound healing: Phoenix rising
Debbie Walker (2010)
Solution and surface effects on plasma fibronectin structure
N. Tooney (1983)
Fibroblasts and myofibroblasts in wound healing
I. Darby (2014)
Systematic review of molecular mechanism of action of negative‐pressure wound therapy
G. Glass (2014)
Gas foaming of segmented poly(ester amide) films
P. Lips (2005)
SHAPE-DEFINING SCAFFOLDS FOR MINIMALLY INVASIVE TISSUE ENGINEERING
A. Thornton (2004)
Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads
F. L. Mi (2003)
Synthesis and characterization of Pluronic® grafted chitosan copolymer as a novel injectable biomaterial
H. J. Chung (2005)
Spatially controlled hydrogel mechanics to modulate stem cell interactions
Ross Marklein (2010)
Microengineered hydrogels for tissue engineering.
A. Khademhosseini (2007)
Mechanotransduction gone awry
D. E. Jaalouk (2009)
In vivo measurements of the elastic mechanical properties of human skin by indentation tests.
C. Pailler-Mattéi (2008)
Regulation of cellular morphology using temperature-responsive hydrogel for integrin-mediated mechanical force stimulation.
K. Yamaki (2009)
A case Series Describing Thermal Injury Resulting From Zeolite Use for Hemorrhage Control in Combat Operations
J. McManus (2007)
Friction of hydrogels with controlled surface roughness on solid flat substrates.
S. Yashima (2014)
Early bone formation around calcium-ion-implanted titanium inserted into rat tibia.
T. Hanawa (1997)
Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and alpha-cyclodextrin.
J. Li (2003)
Extracellular-matrix tethering regulates stem-cell fate.
Britta Trappmann (2012)
Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates
M. C. Wake (1994)
Substrate stiffness modulates gene expression and phenotype in neonatal cardiomyocytes in vitro.
Giancarlo Forte (2012)
In situ injectable nano-composite hydrogel composed of curcumin, N,O-carboxymethyl chitosan and oxidized alginate for wound healing application.
X. Li (2012)
Injectable preformed scaffolds with shape-memory properties
S. Bencherif (2012)
Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers
A. Sawhney (1993)
Development of a long-acting, protein-loaded, redox-active, injectable gel formed by a polyion complex for local protein therapeutics.
S. Ishii (2016)
Negative-Pressure Wound Therapy II: Negative-Pressure Wound Therapy and Increased Perfusion. Just an Illusion?
N. Kairinos (2009)
Microscale technologies for tissue engineering and biology.
A. Khademhosseini (2006)
Military trauma care in Birmingham: observational study of care requirements and resource utilisation.
P. Jackson (2014)
Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture.
Li-Shan Wang (2010)
In situ cell manipulation through enzymatic hydrogel photopatterning.
Katarzyna A. Mosiewicz (2013)
Fabrication of injectable, cellular, anisotropic collagen tissue equivalents with modular fibrillar densities.
B. Marelli (2015)
Ex vivo expansion of limbal stem cells is affected by substrate properties.
R. R. Jones (2012)
Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials
Praveen Thoniyot (2015)
Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells.
C. Verbeke (2015)
Moisture-cured silicone-urethanes-candidate materials for tissue engineering: a biocompatibility study in vitro.
P. Mrowka (2010)
Photo-activated ionic gelation of alginate hydrogel: real-time rheological monitoring of the two-step crosslinking mechanism.
Alina K. Higham (2014)
The effect of electrical stimulation on the differentiation of hESCs adhered onto fibronectin-coated gold nanoparticles. Biomaterials
DG Woo (2009)
Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) Hydrogels
A. A. Aimetti (2009)
Synthesis of two-component injectable polyurethanes for bone tissue engineering.
Ian C Bonzani (2007)
The phase mixing of moisture cured polyurethane-urea during cure
D. Chattopadhyay (2005)
The effect of electrical stimulation on the differentiation of hESCs adhered onto fibronectin-coated gold nanoparticles.
D. Woo (2009)
Injectable gels for tissue engineering
A. Gutowska (2001)
Thermoresponsive macroporous scaffolds prepared by emulsion templating.
S. Zhou (2012)
Hydrolytically degradable hyaluronic acid hydrogels with controlled temporal structures.
S. Sahoo (2008)
Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.
Rachel J. Jerrell (2016)
Application of topical negative pressure for traumatic amputations.
P. Guyver (2013)
Vacuum‐Assisted Closure: A New Method for Wound Control and Treatment: Clinical Experience
L. Argenta (1997)
Injectable polyurethane composite scaffolds delay wound contraction and support cellular infiltration and remodeling in rat excisional wounds.
Elizabeth J. Adolph (2012)
Effects of Negative Pressure Wound Therapy on Mesenchymal Stem Cells Proliferation and Osteogenic Differentiation in a Fibrin Matrix
J. Zhu (2014)
Influence of negative pressure on the viability of adipocytes and mesenchymal stem cell, considering the device method used to harvest fat tissue.
Luiz Charles-de-Sá (2015)
Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds.
S. Guelcher (2006)
In vitro surface reaction layer formation and dissolution of calcium phosphate cement-bioactive glass composites.
C. Liu (2008)
Matrix control of stem cell
S Even-Ram (2006)
Outcomes in lower limb amputation following trauma: a systematic review and meta-analysis.
J. Penn-Barwell (2011)
Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior.
H. Li (2016)
Guided bone regeneration using injectable vascular endothelial growth factor delivery gel.
D. Kaigler (2013)
Tensegrity, cellular biophysics, and the mechanics of living systems.
D. Ingber (2014)
Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin.
I. Yannas (1989)
Injectable silk foams for soft tissue regeneration.
Evangelia Bellas (2015)
Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction.
M. C. D’agostino (2015)
Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.
Basma Hashmi (2014)
Shaping the military wound: issues surrounding the reconstruction of injured servicemen at the Royal Centre for Defence Medicine
D. Evriviades (2011)
Injectable foams for regenerative medicine.
E. Prieto (2014)
Characterization of photocrosslinked alginate hydrogels for nucleus pulposus cell encapsulation.
Alice I Chou (2009)
Glycosaminoglycan hydrogel films as bio-interactive dressings for wound healing.
K. R. Kirker (2002)
Supercritical carbon dioxide: putting the fizz into biomaterials
J. J. Barry (2005)
Effect of the cross-linking degree on the morphology of poly(NIPAAm-co-AAc) hydrogels
Regiane Christine da Silva (2007)
Dual-setting brushite-silica gel cements.
Martha Geffers (2015)
Mechanotransduction of fluid stresses governs 3D cell migration
William J. Polacheck (2014)
Evaluation of orthopaedic injuries in Operation Enduring Freedom.
D. Lin (2004)
Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids
R. Muzzarelli (2009)
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Microencapsulation improves chondrogenesis in vitro and cartilaginous matrix stability in vivo compared to bulk encapsulation.
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Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula
J. Huang (2018)
Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities.
Kevin J De France (2018)
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
B. Homayun (2019)
Correction: Preparation of a novel injectable in situ-gelling nanoparticle with applications in controlled protein release and cancer cell entrapment
Min Kyung Khang (2018)
On the electrical conductivity of alginate hydrogels
G. Kaklamani (2018)
A Potential Filling Material for Wound Healing and Shaping: Acellular Dermal Matrix Combined with Autologous Dermis
S. Qu (2019)
High‐strength hydrogels: Microstructure design, characterization and applications
Jiachuan Hua (2018)
Gut bioengineering promotes gut repair and pharmaceutical research: a review
J. Huang (2019)
Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering
Adam Chyzy (2020)
3D-printable self-healing and mechanically reinforced hydrogels with host-guest non-covalent interactions integrated into covalently linked networks.
Zhifang Wang (2019)
Adipose-Derived Stem Cells in Aesthetic Surgery
G. Glass (2019)