Online citations, reference lists, and bibliographies.
← Back to Search

The Bethesda System For Reporting Thyroid Cytopathology.

E. Cibas, Syed Z. Ali
Published 2009 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
OBJECTIVE To address terminology and other issues related to thyroid fine-needle aspiration (FNA), the National Cancer Institute (NCI) hosted The NCI Thyroid FNA State of the Science Conference. The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for the Bethesda System for Reporting Thyroid Cytopathology. DESIGN Participants of the Atlas Project were selected from among the committee members of the NCI FNA State of the Science Conference and other participants at the live conference. The terminology framework was based on a literature search of English language publications dating back to 1995 using PubMed as the search engine; online forum discussions ( http://thyroidfna.cancer.gov/forums/default.aspx ); and formal interdisciplinary discussions held on October 22 and 23, 2007, in Bethesda, MD. MAIN OUTCOME For clarity of communication, the Bethesda System for Reporting Thyroid Cytopathology recommends that each report begin with one of the six general diagnostic categories. Each of the categories has an implied cancer risk that links it to an appropriate clinical management guideline. CONCLUSIONS The project participants hope that the adoption of this framework will facilitate communication among cytopathologists, endocrinologists, surgeons, and radiologists; facilitate cytologic-histologic correlation for thyroid diseases; facilitate research into the understanding of thyroid diseases; and allow easy and reliable sharing of data from different laboratories for national and international collaborative studies.
This paper references
10.1016/0002-9343(82)90731-8
Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care.
B. Hamberger (1982)
10.1016/0002-9343(82)90719-7
Cardiac conduction abnormalities in Reiter's syndrome.
G. Ruppert (1982)
Fine needle aspiration cytology of the thyroid, 1980 to 1986.
J. Goellner (1987)
10.1002/DC.2840040119
How does one separate cellular follicular lesions of the thyroid by fine‐needle aspiration biopsy?
K. Suen (1988)
[Diagnosis and treatment of differentiated thyroid carcinoma].
L. Schelfhout (1989)
Long-term follow-up of patients with benign thyroid fine-needle aspiration cytologic diagnoses.
C. Grant (1989)
Long-term follow-up of patients with benign thyroid fine-needle aspiration cytologic diagnoses. Surgery
CS Grant (1989)
10.1016/S0272-2712(18)30434-7
Fine-needle aspiration cytology of the thyroid. A 12-year experience with 11,000 biopsies.
H. Gharib (1993)
10.7326/0003-4819-118-4-199302150-00007
Fine-Needle Aspiration Biopsy of the Thyroid: An Appraisal
H. Gharib (1993)
Non-diagnostic fine needle aspiration biopsy: a dilemma in management of nodular thyroid disease.
C. Mchenry (1993)
Value of repeat fine needle aspiration (FNA) of the thyroid
K H Van Hoeven (1994)
Value of repeat fine needle aspiration (FNA) of the thyroid [Abstract
KH van Hoeven (1994)
10.4065/72.10.913
Factors that predict malignant thyroid lesions when fine-needle aspiration is "suspicious for follicular neoplasm".
R. Schlinkert (1997)
10.1016/S0272-2712(18)30159-8
Fine needle aspiration cytology of the thyroid.
P. Gutman (1998)
NCCN thyroid carcinoma practice guidelines
EL Mazzaferri (1999)
NCCN thyroid carcinoma practice guidelines. Oncology
EL Mazzaferri (1999)
10.1002/1097-0142(20001225)90:6<357::AID-CNCR6>3.0.CO;2-4
Usefulness of fine‐needle aspiration in the diagnosis of thyroid carcinoma
C. Ravetto (2000)
10.1002/1097-0339(200012)23:6<380::AID-DC3>3.0.CO;2-0
Thyroid nodules with FNA cytology suspicious for follicular variant of papillary thyroid carcinoma: Follow‐up and management
S. Logani (2000)
Usefulness of fineneedle aspiration in the diagnosis of thyroid carcinoma: a retrospective study in 37,895 patients
C Ravetto (2000)
10.1309/M3K5-23C2-455E-0HB5
Accuracy of thyroid fine-needle aspiration using receiver operator characteristic curves.
A. Renshaw (2001)
10.1089/105072501750159714
Thyroid cytology and the risk of malignancy in thyroid nodules: importance of nuclear atypia in indeterminate specimens.
A. Kelman (2001)
10.1043/0003-9985(2001)125<0484:AOFNAO>2.0.CO;2
Accuracy of fine-needle aspiration of thyroid.
M. Amrikachi (2001)
10.1002/DC.10043
Diagnosis of “follicular neoplasm”: A gray zone in thyroid fine‐needle aspiration cytology
Z. Baloch (2002)
10.1309/QDLD-FTY3-M8ED-CX6U
Focal features of papillary carcinoma of the thyroid in fine-needle aspiration material are strongly associated with papillary carcinoma at resection.
A. Renshaw (2002)
Fine-needle aspiration of follicular lesions of the thyroid: diagnosis and follow-up Diagnosis of " follicular neoplasm " : a gray zone in thyroid fine-needle aspiration cytology
Ms Deveci (2002)
10.1016/S0002-9440(10)63902-8
Genetic and biological subgroups of low-stage follicular thyroid cancer.
C. French (2003)
Pathology and genetics of tumours of endocrine organs
R. DeLellis (2004)
10.1002/DC.20132
Does the fine‐needle aspiration diagnosis of “Hürthle‐cell neoplasm/follicular neoplasm with oncocytic features” denote increased risk of malignancy?
T. Giorgadze (2004)
10.1002/cncr.20832
“Atypical” cells in fine‐needle aspiration biopsy specimens of benign thyroid cysts
W. Faquin (2005)
10.1159/000326192
Fine Needle Aspiration Cytology of the Thyroid
S. Jogai (2005)
Atypical” cells in fineneedle aspiration biopsy specimens of benign thyroid
WC Faquin (2005)
10.1002/cncr.21709
“Atypical” cells in fine‐needle aspiration biopsy specimens of benign thyroid cysts
Y. Oertel (2006)
10.1186/1742-6413-3-9
Fine-needle aspiration of follicular lesions of the thyroid. Diagnosis and follow-Up
M. Deveci (2006)
10.1002/DC.20440
Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine‐needle aspiration?
Robert T. Pu (2006)
Fineneedle aspiration of follicular lesions of the thyroid. Diagnosis and follow-up. CytoJournal 3:9
MS Deveci (2006)
Fineneedle aspiration of follicular lesions of the thyroid
MS Deveci (2006)
10.1002/cncr.23116
Long‐term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation
L. Yassa (2007)
10.1002/DC.20702
Macrofollicular variant of papillary carcinoma: A potential thyroid FNA pitfall
D. Chung (2007)
10.1002/cncr.22955
Fine‐needle aspiration of thyroid nodules: A study of 4703 patients with histologic and clinical correlations
Jack Yang (2007)
Fineneedle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations
J Yang (2007)
10.1002/dc.20832
Post‐thyroid FNA testing and treatment options: A synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference
L. Layfield (2008)
10.1186/1742-6413-5-6
The National Cancer Institute Thyroid fine needle aspiration state of the science conference: a summation
Z. Baloch (2008)
10.1002/dc.20830
Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: A synopsis of the National Cancer Institute Thyroid Fine‐Needle Aspiration State of the Science Conference
Z. Baloch (2008)
10.1309/AJCPPHLWMI3JV4LA
The Bethesda System For Reporting Thyroid Cytopathology.
E. Cibas (2009)
10.1089/thy.2009.1602
Guidelines for guidelines: content, accountability, peer review, and intellectual ownership.
C. Emerson (2009)
The 2009 American
Efisio Puxeddu (2009)
Association Guidelines for Management of Thyroid Nodules and Differentiated Thyroid Cancer : Progress on the Road from Consensus - to Evidence - Based Practice
Charles H. Emerson (2009)
Cibas ES (eds) 2009 The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria, and Explanatory Notes
SZ Ali (2009)
American Thyroid Association Guidelines for Management of Thyroid Nodules and Differentiated Thyroid Cancer: Progress on the Road from Consensus-to Evidence-Based Practice
Efisio Puxeddu (2009)
10.4132/KOREANJPATHOL.2010.44.6.657
The Analysis of Indeterminate Category in Thyroid Fine Needle Aspiration
S. Min (2010)
10.1089/thy.2010.0015
Diagnostic value of a cytomorphological subclassification of follicular patterned thyroid lesions: a study of 927 consecutive cases with histological correlation.
M. Deandrea (2010)
10.1016/j.surg.2010.09.017
Effect of the Bethesda system for reporting thyroid cytopathology on thyroidectomy rates and malignancy risk in cytologically indeterminate lesions.
J. Rabaglia (2010)
10.1089/thy.2009.0283
BRAF status of follicular variant of papillary thyroid carcinoma and its relationship to its clinical and cytological features.
A. Proietti (2010)
10.1111/j.1365-2303.2010.00751.x
Diagnostic terminology for reporting thyroid fine needle aspiration cytology: European Federation of Cytology Societies thyroid working party symposium, Lisbon 2009
G. Kocjan (2010)
10.1111/j.1365-2303.2010.00750.x
Thyroid fine needle aspiration cytology: a review of the National Cancer Institute state of the science symposium
L. Layfield (2010)
10.1016/j.surg.2010.09.029
Routine second-opinion cytopathology review of thyroid fine needle aspiration biopsies reduces diagnostic thyroidectomy.
T. Davidov (2010)
10.1016/j.surg.2011.09.006
The impact of atypia/follicular lesion of undetermined significance on the rate of malignancy in thyroid fine-needle aspiration: evaluation of the Bethesda System for Reporting Thyroid Cytopathology.
J. Broome (2011)
10.1089/thy.2011.2103.ed
Can thyroid ultrasound and related procedures provide diagnostic information about thyroid nodules: a look at the guidelines.
C. Emerson (2011)
10.4174/jkss.2011.81.2.75
Review of atypical cytology of thyroid nodule according to the Bethesda system and its beneficial effect in the surgical treatment of papillary carcinoma
Y. Chung (2011)
10.1097/01.ruq.0000405292.34741.26
An Ultrasound Model to Discriminate the Risk of Thyroid Carcinoma
Y. Endo (2011)
10.1016/j.jpedsurg.2011.02.013
Pediatric thyroidectomy: a collaborative surgical approach.
J. Wood (2011)
10.1089/thy.2011.0146
Predictors of malignancy in patients with cytologically suspicious thyroid nodules.
M. Castro (2011)
10.1111/j.1365-2265.2011.04011.x/abstract
Factors affecting inadequate sampling of ultrasound-guided fine-needle aspiration biopsy of thyroid nodules.
윤정현 (2011)
10.1089/thy.2010.0243
A large multicenter correlation study of thyroid nodule cytopathology and histopathology.
Chung-Che Charles Wang (2011)
10.1016/j.anorl.2011.01.003
Interest of fine-needle aspiration cytology in thyroid nodule.
M. Sellami (2011)
10.1089/thy.2011.0014
Immunocytochemistry with cytokeratin 19 and anti-human mesothelial cell antibody (HBME1) increases the diagnostic accuracy of thyroid fine-needle aspirations: preliminary report of 150 liquid-based fine-needle aspirations with histological control.
B. Cochand-Priollet (2011)
10.1245/s10434-011-1605-7
Inadequate Cytology in Thyroid Nodules: Should We Repeat Aspiration or Follow-Up?
J. Yoon (2011)
10.1089/thy.2010.0458
The diagnostic accuracy of ultrasound-guided fine-needle aspiration biopsy and the sonographic differences between benign and malignant thyroid nodules 3 cm or larger.
J. Yoon (2011)
10.5858/arpa.2010-0606-RA
Quality improvement in cytology: where do we go from here?
A. Renshaw (2011)
10.1007/s12022-011-9156-9
Changes Associated with Percutaneous Ethanol Injection in the Treatment of Thyroid Nodules
G. C. A. Schrut (2011)
10.3346/jkms.2011.26.2.237
Malignancy Rate in Sonographically Suspicious Thyroid Nodules of Less than a Centimeter in Size Does Not Decrease with Decreasing Size
Y. Bo (2011)
10.3342/KJORL-HNS.2011.54.1.69
A Case of Minimal Invasive Follicular Carcinoma in Childhood
S. Y. Ahn (2011)
10.1016/j.jpedsurg.2010.09.009
Thyroid surgery at Children's Hospital Boston: a 35-year single-institution experience.
S. Scholz (2011)
10.3348/kjr.2011.12.1.1
Ultrasonography and the Ultrasound-Based Management of Thyroid Nodules: Consensus Statement and Recommendations
W. Moon (2011)
Nodule Cytopathology and Histopathology
Charles H. Emerson (2011)
Nodules
Jung Hyun Yoon (2011)
Diagnostic value of liquid-based (LiquiPREP) preparations and interobserver reproducibility in fine needle aspiration cytology of the nodular thyroid lesions. Diagnostic Cytopathology n/a-n/a
U. S. Tetikkurt (2011)
Nodules 3 cm or Larger
Seon Hyeong Choi (2011)
The Johns Hopkins Medical Institutions The Johns Hopkins Medical Institutions
Pedro Patricio De Agustin
Vanishing Thyroid Tumors: A Diagnostic Dilemma Following Ultrasound Guided Fine Needle Aspiration
American Society for Clinical Pathology AJCP / SPECIAL ARTICLE
Baloch ZW 2006 Fineneedle aspiration of follicular lesions of the thyroid. Diagnosis and follow-up
M S Deveci
Kwangseon Min, Hye-Rim Park. 2010. The Analysis of Indeterminate Category in Thyroid Fine Needle Aspiration
Jinwon Soo Kee Min



This paper is referenced by
10.1002/dc.24756
Analysis of intra‐observer and inter‐observer variability of pathologists for non‐benign thyroid fine needle aspiration cytology according to Bethesda system categories
T. Y. Kuzan (2021)
10.21037/AOT-20-44
Impact of healthcare resources on management of indeterminate thyroid tumors
E. Alçi (2021)
10.1016/j.surg.2021.05.016
Fine needle aspiration and the Bethesda system: Correlation with histopathology in 1,228 surgical patients.
Samantha M Linhares (2021)
10.1177/0003489421993976
Diagnostic Lobectomy for Bethesda III Thyroid Nodules: Pathological Outcomes and Risk Factors for Malignancy
Benjamin K Walters (2021)
10.3390/diagnostics11081396
Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods
Chih-Yi Liu (2021)
Surgeon Performed Ultrasound in Assessing Thyroid Nodule Using American College of Radiology Tirads and Total Malignancy Score (TMS): A Validation Cross Sectional Study
Muhammad Latar (2021)
10.1159/000513066
Cytological Sub-Classification of Atypia of Undetermined Significance May Predict Malignancy Risk in Thyroid Nodules
Abdulghani S. Elomami (2021)
10.1016/B978-0-323-66127-0.00010-7
The Evaluation and Management of Thyroid Nodules
K. Kovatch (2021)
10.1111/cyt.12970
Revised Bethesda System for Reporting Thyroid Cytology: Lessons learned from an appraisal of 5 years of experience in a central hospital
I. E. El Hag (2021)
10.1186/s13244-021-01053-y
Role of the cytopathologist during the procedure of fine-needle aspiration biopsy of thyroid nodules
F. Feletti (2021)
10.1530/EC-21-0034
Assessment of perinodular stiffness in differentiating malignant from benign thyroid nodules
Lei Hu (2021)
10.3390/cancers13174467
Diagnostic Performance of Kwak, EU, ACR, and Korean TIRADS as Well as ATA Guidelines for the Ultrasound Risk Stratification of Non-Autonomously Functioning Thyroid Nodules in a Region with Long History of Iodine Deficiency: A German Multicenter Trial
P. Seifert (2021)
Thyroid Oncocytic Cell in Cytological and Histologic Reports: Institutional Experience
José Marçalo (2021)
10.1002/cncy.22449
Subacute (De Quervain) thyroiditis during the COVID‐19 pandemic
R. Abreu (2021)
10.1007/s12022-021-09679-w
Follicular Epithelial Dysplasia as Hashimoto Thyroiditis-Related Atypia: a Series of 91 Specimens
I. Kholová (2021)
10.1002/jcla.23920
A five‐gene panel refines differential diagnosis of thyroid nodules
Sang Lu (2021)
10.1136/bcr-2020-236399
Primary thyroid leiomyosarcoma: a diagnostic and therapeutic challenge
M. T. Bashir (2021)
10.1002/dc.24823
Malignancy outcomes and the impact of repeat fine needle aspiration of thyroid nodules with Bethesda category III cytology: A multicenter experience
D. Köseoğlu (2021)
10.3906/sag-2011-177
Can preoperative modified systemic inflammation score (mSIS) be used to predict malignancy in persistent nondiagnostic thyroid nodules?
Hakan Ataş (2021)
10.3389/fendo.2021.566362
Radiofrequency Thermal Ablation for a Small Papillary Thyroid Carcinoma in a Patient Unfit for Surgery: A Case Report
F. Maletta (2021)
10.1007/s00405-021-06733-5
Risk-stratification of thyroid nodules examined by 18FDG-PET/CT while ensuring congruity between imaging and histopathological localization
Peter Bakkegaard (2021)
10.3390/jcm10050970
Obesity and Overweight Are Associated with Minimal Extrathyroidal Extension, Multifocality and Bilaterality of Papillary Thyroid Cancer
Krzysztof Kaliszewski (2021)
Agreement between thyroid nodules ultrasound and cytology of fine needle aspiration (FNA) based on TIRADS and Bethesda system
S. Livani (2021)
10.1007/s40618-021-01570-z
Evaluation of thyroid nodules by shear wave elastography: a review of current knowledge
K. Z. Swan (2021)
10.7759/cureus.16708
Impact of Ultrasonographic Features for Thyroid Malignancy in Patients With Bethesda Categories III, IV, and V: A Retrospective Observational Study in a Tertiary Center
N. A. Hacım (2021)
10.1016/j.ejrad.2021.109571
Evaluation of thyroid micro-carcinoma using shear wave elastography: Initial experience with qualitative and quantitative analysis.
Shi Tan (2021)
10.3390/jcm10143082
Atypia and Follicular Lesions of Undetermined Significance in Subsequent Biopsy Result: What Clinicians Need to Know
Krzysztof Kaliszewski (2021)
10.3889/oamjms.2021.6442
Reevaluation of the Correlations between Ultrasound Features of Thyroid Nodules and Grades of Bethesda Classification
E. Tako (2021)
10.1007/s00330-020-07591-1
Comparison of diagnostic performance of the ACR and Kwak TIRADS applying the ACR TIRADS’ size thresholds for FNA
Sun Huh (2021)
10.1111/cyt.12984
False positive cases in thyroid cytopathology – the experience of a single laboratory and a systematic review
T. Mezei (2021)
10.2478/raon-2021-0025
Five-year Follow-up and Clinical Outcome in Euthyroid Patients with Thyroid Nodules
Katica Bajuk Studen (2021)
10.1186/s13000-021-01087-2
Diagnostic pitfall of thyroid fine-needle aspiration induced fibrosis: follicular adenoma mimicking medullary thyroid carcinoma in frozen section
W. Moon (2021)
See more
Semantic Scholar Logo Some data provided by SemanticScholar