Online citations, reference lists, and bibliographies.
← Back to Search

Focal White Matter Changes In Spasmodic Dysphonia: A Combined Diffusion Tensor Imaging And Neuropathological Study.

K. Simonyan, F. Tovar-Moll, J. Ostuni, M. Hallett, V. Kalasinsky, M. Lewin-Smith, E. Rushing, A. Vortmeyer, C. Ludlow
Published 2008 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Spasmodic dysphonia is a neurological disorder characterized by involuntary spasms in the laryngeal muscles during speech production. Although the clinical symptoms are well characterized, the pathophysiology of this voice disorder is unknown. We describe here, for the first time to our knowledge, disorder-specific brain abnormalities in these patients as determined by a combined approach of diffusion tensor imaging (DTI) and postmortem histopathology. We used DTI to identify brain changes and to target those brain regions for neuropathological examination. DTI showed right-sided decrease of fractional anisotropy in the genu of the internal capsule and bilateral increase of overall water diffusivity in the white matter along the corticobulbar/corticospinal tract in 20 spasmodic dysphonia patients compared to 20 healthy subjects. In addition, water diffusivity was bilaterally increased in the lentiform nucleus, ventral thalamus and cerebellar white and grey matter in the patients. These brain changes were substantiated with focal histopathological abnormalities presented as a loss of axonal density and myelin content in the right genu of the internal capsule and clusters of mineral depositions, containing calcium, phosphorus and iron, in the parenchyma and vessel walls of the posterior limb of the internal capsule, putamen, globus pallidus and cerebellum in the postmortem brain tissue from one patient compared to three controls. The specificity of these brain abnormalities is confirmed by their localization, limited only to the corticobulbar/corticospinal tract and its main input/output structures. We also found positive correlation between the diffusivity changes and clinical symptoms of spasmodic dysphonia (r = 0.509, P = 0.037). These brain abnormalities may alter the central control of voluntary voice production and, therefore, may underlie the pathophysiology of this disorder.
This paper references
10.1006/exnr.1999.7171
Tottering Mouse Motor Dysfunction Is Abolished on the Purkinje Cell Degeneration (pcd) Mutant Background
D. B. Campbell (1999)
10.1002/CPHY.CP010233
Perceptual Structures and Distributed Motor Control
M. Arbib (1981)
10.1212/WNL.40.2.309
Corticofugal projections to the motor nuclei of the brainstem and spinal cord in humans
T. Iwatsubo (1990)
10.1016/j.bandl.2005.06.001
Neural modeling and imaging of the cortical interactions underlying syllable production
F. Guenther (2006)
10.1016/S0165-1781(03)00202-6
Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging
M. Casanova (2003)
Dystonia: abnormal movements result from loss of inhibition.
M. Hallett (2004)
10.1093/BRAIN/120.4.571
Botulinum toxin does not reverse the cortical dysfunction associated with writer's cramp. A PET study.
A. O. Ceballos-Baumann (1997)
10.1016/j.neuroscience.2004.06.077
Extrasynaptic volume transmission and diffusion parameters of the extracellular space
E. Syková (2004)
10.1111/j.1600-0404.1996.tb07049.x
Basal ganglia and thalamo‐cortical hypermetabolism in patients with spasmodic torticollis
Giuseppe Galardi (1996)
Effects of lipid peroxidation on GABA uptake and release in iron-induced seizures.
Z. H. Zhang (1989)
10.1002/1522-2594(200006)43:6<921::AID-MRM23>3.0.CO;2-I
Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain
S. Pajevic (2000)
10.1006/nimg.2000.0672
Differential Contributions of Motor Cortex, Basal Ganglia, and Cerebellum to Speech Motor Control: Effects of Syllable Repetition Rate Evaluated by fMRI
D. Wildgruber (2001)
10.1212/01.wnl.0000230141.40784.09
Autosomal dominant dystonia-plus with cerebral calcifications
Z. Wszolek (2006)
10.1007/s004150170263
Cerebral activation patterns in patients with writer's cramp: a functional magnetic resonance imaging study
C. Preibisch (2001)
10.1016/j.neuroimage.2006.12.041
Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: A combined fMRI and DTI study
M. Vernooij (2007)
MRI Atlas of Human White Matter
S. Wakana (2005)
Internal capsule: normal anatomy and ischemic changes demonstrated by computed tomography.
C. Manelfe (1981)
Automated image registration
R. Woods (1993)
10.1212/01.wnl.0000184478.59063.db
“Silent event-related” fMRI reveals reduced sensorimotor activation in laryngeal dystonia
B. Haslinger (2005)
10.1148/RADIOL.2343032087
Diffusion-tensor MR tractography of somatotopic organization of corticospinal tracts in the internal capsule: initial anatomic results in contradistinction to prior reports.
A. Holodny (2005)
10.1177/000348940010900215
Effects of Botulinum Toxin on Pathophysiology in Spasmodic Dysphonia
S. Bielamowicz (2000)
10.1016/0093-934X(82)90058-X
On the role of the anterior cingulate cortex in phonation: A case report
U. Jürgens (1982)
10.1212/WNL.51.3.819
Putamen volume in idiopathic focal dystonia
K. Black (1998)
10.1177/000348948509400111
Symptom Improvement of Spastic Dysphonia in Response to Phonatory Tasks
C. S. Bloch (1985)
10.1097/00019052-199808000-00007
Functional brain networks in movement disorders.
D. Eidelberg (1998)
10.1523/JNEUROSCI.09-11-04033.1989
Regional cerebral glucose utilization reveals widespread abnormalities in the motor system of the rat mutant dystonic
L. Brown (1989)
10.1016/S0892-1997(00)80008-9
Adductor spasmodic dysphonia and muscular tension dysphonia: acoustic analysis of sustained phonation and reading.
C. Sapienza (2000)
10.1016/j.neuroimage.2006.02.024
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
S. Smith (2006)
10.1002/MDS.870030410
Degenerative cerebellar ataxia and focal dystonia
N. Fletcher (1988)
Brain stem pathology in cranial dystonia.
R. Zweig (1988)
10.1016/j.cmpb.2005.08.004
DtiStudio: Resource program for diffusion tensor computation and fiber bundle tracking
H. Jiang (2006)
10.1016/0306-4522(94)00618-F
Time-dependent changes in iron levels and associated neuronal loss within the substantia nigra following lesions within the neostriatum/globus pallidus complex
S. Sastry (1995)
10.1212/01.wnl.0000269478.69285.7e
PREDOMINANT DYSTONIA WITH MARKED CEREBELLAR ATROPHY: A RARE PHENOTYPE IN FAMILIAL DYSTONIA
J. Hagenah (2007)
10.1016/j.brainres.2007.02.020
The descending motorcortical pathway to the laryngeal motoneurons in the squirrel monkey
U. Jürgens (2007)
10.1097/01.WNR.0000230500.03330.01
White matter abnormalities in dystonia normalize after botulinum toxin treatment
A. Blood (2006)
10.1002/NBM.782
The basis of anisotropic water diffusion in the nervous system – a technical review
C. Beaulieu (2002)
10.1002/ana.10073
Impaired brain GABA in focal dystonia
L. Levy (2002)
10.1177/000348949510401203
Abnormalities in Long Latency Responses to Superior Laryngeal Nerve Stimulation in Adductor Spasmodic Dysphonia
C. Ludlow (1995)
Abnormalities in long latency responses to superior laryngeal nerve stimulation in 458
Cl Ludlow (2008)
Abnormalities in long latency responses to superior laryngeal nerve stimulation in Page 12 of 13
Cl Ludlow (2007)
Effects of lipid peroxidation on GABA uptake and release in iron-induced seizures.
Z. Zh (1989)
10.1109/42.796284
Nonrigid registration using free-form deformations: application to breast MR images
D. Rueckert (1999)
10.1046/j.1469-7580.2000.19730335.x
The anatomy of language: contributions from functional neuroimaging
C. Price (2000)
10.1016/S0006-3495(94)80775-1
MR diffusion tensor spectroscopy and imaging.
P. Basser (1994)
10.1148/RADIOLOGY.219.1.R01AP14101
Mild cognitive impairment and Alzheimer disease: regional diffusivity of water.
K. Kantarci (2001)
10.1212/WNL.40.10.1499
Capsular genu syndrome
J. Bogousslavsky (1990)
10.1148/RADIOLOGY.201.3.8939209
Diffusion tensor MR imaging of the human brain.
C. Pierpaoli (1996)
10.1002/NBM.787
Applications of diffusion‐weighted and diffusion tensor MRI to white matter diseases – a review
M. Horsfield (2002)
10.1006/nimg.2001.0765
Water Diffusion Changes in Wallerian Degeneration and Their Dependence on White Matter Architecture
C. Pierpaoli (2001)
10.1001/ARCHNEUR.1995.00540300067015
Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging.
J. Binder (1995)
10.1093/BRAIN/121.7.1195
The pathophysiology of primary dystonia.
A. Berardelli (1998)
Ann Otol Rhinol Laryngol
Dysphonia Adductor Spasmodic (1995)
Pure motor hemiplegia and computed tomography. 19 cases.
T. Soisson (1982)
10.1002/ana.20177
Microstructural white matter changes in carriers of the DYT1 gene mutation
M. Carbon (2004)
10.2152/JMI.52.186
Regional changes of fractional anisotropy with normal aging using statistical parametric mapping (SPM).
K. Furutani (2005)
10.1016/S0022-510X(01)00487-7
Acute and chronic changes of the apparent diffusion coefficient in neurological disorders—biophysical mechanisms and possible underlying histopathology
A. Gass (2001)
10.1002/ana.20225
Brainstem pathology in DYT1 primary torsion dystonia
K. S. P. McNaught (2004)
10.1016/S0306-4522(97)00672-6
Cerebellar circuitry is activated during convulsive episodes in the tottering (tg/tg) mutant mouse
D. Campbell (1998)
10.1523/JNEUROSCI.22-17-07825.2002
Abnormal Cerebellar Signaling Induces Dystonia in Mice
Carolyn E. Pizoli (2002)
10.1097/00005537-199604000-00017
Laryngeal Muscle Activity During Speech Breaks in Adductor Spasmodic Dysphonia
E. A. Nash (1996)
10.1093/BRAIN/117.4.859
The behavioural and motor consequences of focal lesions of the basal ganglia in man.
K. Bhatia (1994)
Corticobular connexions to the pons and lower brain-stem in man: an anatomical study.
H. Kuypers (1958)
10.1212/01.wnl.0000246112.19504.61
A new twist on the anatomy of dystonia
H. Jinnah (2006)
Quantitative evaluation of the pyramidal tract segmented by diffusion tensor tractography: feasibility study in patients with amyotrophic lateral sclerosis.
S. Aoki (2005)
10.1001/ARCHNEUR.55.5.601
The neurophysiology of dystonia.
M. Hallett (1998)
10.1177/1073858402239593
Dystonia: Lessons from Brain Mapping
S. Meunier (2003)
10.1002/mds.21295
Structural white matter abnormalities in patients with idiopathic dystonia
L. Bonilha (2007)
10.1002/MDS.870130321
Cerebral and cerebellar activation in correlation to the action‐induced dystonia in Writer's cramp
T. Odergren (1998)
10.1002/MDS.870130419
[3H]‐2‐Deoxyglucose uptake study in mutant dystonic hamsters: Abnormalities in discrete brain regions of the motor system
A. Richter (1998)
10.1093/BRAIN/81.3.364
CORTICOBULBAR CONNEXIONS TO THE PONS AND LOWER BRAIN-STEM IN MAN
H. G. Kuypers (1958)
10.1001/ARCHNEUR.1960.03840090124020
Handbook of Physiology.
F. Plum (1960)
10.1212/WNL.40.2.332
The pyramidal tract.
R. Davidoff (1990)
10.1212/WNL.55.5.673
The metabolic topography of essential blepharospasm
M. Hutchinson (2000)
10.1016/S0892-1997(01)00038-8
Acoustic measures of symptoms in abductor spasmodic dysphonia.
J. D. Edgar (2001)
10.1136/jnnp.2004.056614
Diffusion tensor imaging in primary cervical dystonia
C. Colosimo (2005)
10.1002/hbm.10062
Fast robust automated brain extraction
S. Smith (2002)
10.1016/S0021-9924(00)00039-3
Identification of symptoms for spasmodic dysphonia and vocal tremor: a comparison of expert and nonexpert judges.
J. Barkmeier (2001)
Dystonia: lessons from brain
S Meunier (2003)
10.1044/1092-4388(2006/081)
Alterations in CNS activity induced by botulinum toxin treatment in spasmodic dysphonia: an H215O PET study.
S. O. Ali (2006)
10.1002/MDS.870030209
Meige syndrome: Neuropathology of a case
J. Kulisevsky (1988)
The site of motor corticospinal fibres in the internal capsule of man. A computerised tomographic study of restricted lesions.
G. Tredici (1982)
10.1212/WNL.48.4.1056
A direct comparison of PET activation and electrocortical stimulation mapping for language localization
S. Bookheimer (1997)
10.1002/hbm.1058
Nonparametric permutation tests for functional neuroimaging: A primer with examples
T. Nichols (2002)
10.1016/j.neuroscience.2004.08.031
Afferent cortical connections of the motor cortical larynx area in the rhesus monkey
K. Simonyan (2005)
10.1093/BRAIN/118.6.1411
Functional MRI measurement of language lateralization in Wada-tested patients.
J. Desmond (1995)
10.1016/S0006-8993(02)02960-8
Cortico-cortical projections of the motorcortical larynx area in the rhesus monkey
K. Simonyan (2002)
10.1006/exnr.1993.1064
Cerebellectomy Eliminates the Motor Syndrome of the Genetically Dystonic Rat
M. LeDoux (1993)
10.1002/mrm.10452
Increased brain white matter diffusivity in normal adult aging: Relationship to anisotropy and partial voluming
A. Pfefferbaum (2003)
10.1212/WNL.30.1.59
Localization of the pyramidal tract in the internal capsule by whole brain dissection
E. Ross (1980)
Brain changes in spasmodic dysphonia Brain
(2007)
10.1016/S0149-7634(01)00068-9
Neural pathways underlying vocal control
U. Jürgens (2002)
10.1016/J.JVOICE.2006.05.001
Reliability of clinician-based (GRBAS and CAPE-V) and patient-based (V-RQOL and IPVI) documentation of voice disorders.
M. Karnell (2007)
10.1002/nbm.798
From the diffusion coefficient to the diffusion tensor
D. Le Bihan (2002)
10.1097/00004728-199801000-00027
Automated image registration: I. General methods and intrasubject, intramodality validation.
R. Woods (1998)
10.1523/JNEUROSCI.17-02-00843.1997
Decreased [18F]Spiperone Binding in Putamen in Idiopathic Focal Dystonia
J. Perlmutter (1997)



This paper is referenced by
10.1002/lary.26655
Central voice production and pathophysiology of spasmodic dysphonia
Niv Mor (2018)
10.1002/mds.24055
Bilateral cerebellar stroke presenting with acute dysphonia and late palatal tremor
R. Walsh (2012)
10.1007/s11682-016-9513-x
Neural correlates of dystonic tremor: a multimodal study of voice tremor in spasmodic dysphonia
Diana N Kirke (2016)
10.1016/j.parkreldis.2016.02.003
Brain structural changes in spasmodic dysphonia: A multimodal magnetic resonance imaging study.
V. Kostic (2016)
10.1007/s00702-019-02030-y
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update. II. Hyperkinetic disorders
K. Jellinger (2019)
10.1007/978-1-62703-471-5_11
Neuroimaging of Dystonia
S. Horovitz (2013)
10.1002/mds.25934
What's special about task in dystonia? A voxel‐based morphometry and diffusion weighted imaging study
Ritesh A. Ramdhani (2014)
10.1007/s11910-013-0400-1
The Evolving Role of Diffusion Magnetic Resonance Imaging in Movement Disorders
C. Hess (2013)
10.1016/j.clinph.2019.03.003
Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia
Sanaz Khosravani (2019)
10.4172/2161-119X.S1-003
Acoustic Measures of Phonation during Connected Speech in Adductor Spasmodic Dysphonia
M. Cannito (2012)
10.1002/mds.25567
The focal dystonias: Current views and challenges for future research
H. Jinnah (2013)
10.1044/VVD22.3.104
Epidemiologic Advances in Spasmodic Dysphonia
Kristine Tanner (2012)
10.1002/mds.26502
GNAL mutation in isolated laryngeal dystonia
G. Putzel (2016)
10.1093/brain/aws222
Beyond the arcuate fasciculus: consensus and controversy in the connectional anatomy of language.
A. Dick (2012)
10.1016/j.neuroimage.2012.11.063
Investigating the need of triggering the acquisition for infant diffusion MRI: A quantitative study including bootstrap statistics
L. R. Kozák (2013)
10.1038/s41598-018-34553-x
A novel therapeutic agent, sodium oxybate, improves dystonic symptoms via reduced network-wide activity
K. Simonyan (2018)
10.1016/j.homp.2008.11.009
Treatment of spasmodic dysphonia with homeopathic medicine: a clinical case report.
S. Xue (2009)
InVivoDiffusionTensorImagingandHistopathologyofthe Fimbria-FornixinTemporalLobeEpilepsy
DanielJ . Livy (2010)
10.1111/ene.12151
Sonographic detection of basal ganglia abnormalities in spasmodic dysphonia
U. Walter (2014)
10.4172/2155-6121.1000261
Vocal Cord Dysfunction after an Inhalation Exposure
S. Brooks (2017)
10.1016/j.jvoice.2019.05.016
Laboratory Evaluation of Spasmodic Dysphonia.
S. Othman (2019)
10.1002/lary.27245
Defining differences in patient characteristics between spasmodic dysphonia and laryngeal tremor
Priyesh N Patel (2019)
10.1212/WNL.0000000000007317
Top-down alteration of functional connectivity within the sensorimotor network in focal dystonia
Giovanni Battistella (2019)
Effects of deep brain stimulation on speech in patients with Parkinson’s disease and dystonia
E. Tripoliti (2011)
10.1016/j.jvoice.2012.05.005
Perceptual structure of adductor spasmodic dysphonia and its acoustic correlates.
M. Cannito (2012)
10.1016/j.jvoice.2019.04.003
The Influence of Linguistic Demand on Symptom Expression in Adductor Spasmodic Dysphonia.
L. Froeschke (2019)
TITLE : Spasmodic Dysphonia : Evaluation and Management SOURCE : Grand Rounds Presentation , UTMB , Dept . of Otolaryngology DATE : March 10 , 2009 SENIOR MEDICAL STUDENT : Olvia Revelo FACULTY ADVISOR : Michael Underbrink
F. Quinn (2014)
10.1186/2047-9158-1-12
Anatomical correlates of blepharospasm
S. Horovitz (2012)
10.1523/JNEUROSCI.0384-17.2017
Connectome-Wide Phenotypical and Genotypical Associations in Focal Dystonia
S. Fürtinger (2017)
10.1177/000348941112000708
Spasmodic Dysphonia: Onset, Course, Socioemotional Effects, and Treatment Response
Kristine Tanner (2011)
10.1016/j.anl.2013.10.017
Brain activity related to phonation in young patients with adductor spasmodic dysphonia.
Asanori Kiyuna (2014)
10.1523/JNEUROSCI.1619-09.2010
In Vivo Diffusion Tensor Imaging and Histopathology of the Fimbria-Fornix in Temporal Lobe Epilepsy
L. Concha (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar