Online citations, reference lists, and bibliographies.
← Back to Search

Decreased Natural Killer Cell Activity Is Associated With Severity Of Chronic Fatigue Immune Dysfunction Syndrome.

E. Ojo-Amaize, E. Conley, J. Peter
Published 1994 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Natural killer (NK) cell activity was measured blindly in vitro with blood specimens from 50 healthy individuals and 20 patients with clinically defined chronic fatigue immune dysfunction syndrome (CFIDS) who met the criteria established by the Centers for Disease Control and Prevention (Atlanta). In accordance with a group scoring system of 1-10 points, with 10 being the most severe clinical status, the patient population was stratified into three clinical groups: A (> 7 points), B (5-7 points), and C (< 5 points). NK cell activity was assessed by the number of lytic units (LU), which for the 50 healthy controls varied between 20 and 250 (50%, 20-50 LU; 32%, 51-100 LU; 6%, 101-130 LU; and 12%, > 150 LU). In none of the 20 patients with CFIDS was the NK cell activity > 100 LU. For group C, the 10 patients stratified as having the least severe clinical condition, the measure was 61.0 +/- 21.7 LU; for group B (more severe, n = 7), it was 18.3 +/- 7.3 LU; and for group A (most severe, n = 3), it was 8.0 +/- 5.3 LU. These data suggest a correlation between low levels of NK cell activity and severity of CFIDS, which, if it is confirmed by additional studies of larger groups, might be useful for subgrouping patients and monitoring therapy and/or the progression of CFIDS.
This paper references



This paper is referenced by
10.1186/s13643-019-1202-6
A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome
N. Eaton-Fitch (2019)
10.3390/nu11102315
Anti-Inflammatory Diets and Fatigue
U. Haß (2019)
10.1186/s40360-018-0203-8
Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation
Natalie Eaton (2018)
10.3389/fimmu.2018.01028
Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
J. L. Rivas (2018)
10.3390/molecules22010155
Anti-Fatigue Effects of the Unique Polysaccharide Marker of Dendrobium officinale on BALB/c Mice
W. Wei (2017)
10.20535/1810-0546.2017.3.95070
The Effect of Lactic Acid Bacteria and Bifidobacteria on the Number of Natural Killer Cells in Normal Conditions and in Cases of Intravaginal Staphylococcosis in Mice
L. M. Lazarenko (2017)
10.1186/s12967-016-0859-z
ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
T. Huth (2016)
10.1007/978-3-319-48838-7_29
Fundamental Mechanisms Underlying the Ill Health and Chronic Fatigue Syndrome Suffered by Atomic and Gulf War Veterans: A Unifying Hypothesis
C. Mothersill (2016)
10.1016/J.EUJIM.2016.10.004
Controlled pilot study for cancer patients suffering from chronic fatigue syndrome due to chemotherapy treated with BioBran (MGN-3-Arabinoxylane) and targeted radiofrequency heat therapy
G. Petrovics (2016)
in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
T. Huth (2016)
10.4137/GRSB.S40036
Dysregulation of Protein Kinase Gene Expression in NK Cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients
A. Chacko (2016)
Investigation of Cellular and Genetic Mechanisms Required for Natural Killer Cell Cytotoxic Activity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
T. Huth (2016)
10.1186/s40659-016-0087-2
Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients
T. Nguyen (2016)
10.4137/GRSB.S39861
Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients
T. Huth (2016)
10.4172/2155-9899.1000348
Low NK Cell Activity in Chronic Fatigue Syndrome (CFS) and Relationship to Symptom Severity
D. Strayer (2015)
10.1186/s12865-015-0101-4
Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
S. L. Hardcastle (2015)
10.1016/J.MEHY.2015.10.011
Myalgic encephalomyelitis, chronic fatigue syndrome: An infectious disease
Underhill Ra (2015)
10.1155/2014/721505
Daily Intake of Probiotics with High IFN-γ/IL-10 Ratio Increases the Cytotoxicity of Human Natural Killer Cells: A Personalized Probiotic Approach
Y.-H. Ho (2014)
10.5812/PEDINFECT.13107
NORMAL SALIVARY CORTISOL AND NK CELL FUNCTION IN ADOLESCENTS WITH CHRONIC FATIGUE SYNDROME FOLLOWING INFECTIOUS MONONUCLEOSIS
B. Z. Katz (2013)
INVESTIGATION OF BIOCHEMICAL ANOMALIES IN PEOPLE WITH A VISUAL FORM OF DYSLEXIA: IMPLICATIONS FOR EARLY IDENTIFICATION AND DIETARY INTERVENTION
G. L. Robinson (2013)
10.1007/s13317-013-0051-x
Natural killer cells in patients with severe chronic fatigue syndrome
E. Brenu (2013)
Overnight Storage of Blood in ACD Tubes at 4°C Increases NK Cell Fraction in Peripheral Blood Mononuclear Cells
Dawoon Kim (2013)
10.1186/1479-5876-10-88
Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis
E. Brenu (2011)
Understand the Role of Natural Killer 1
Han Yuen Lam (2011)
Assessment of Immune and Molecular Changes in T Lymphocytes, Natural Killer Cells and Vasoactive Neuropeptides in Chronic Fatigue Syndrome
E. Brenu (2011)
The Effect of Chronic Fatigue Syndrome Severity Subtype on Treatment Responsiveness
Mariya Zaturenskaya (2010)
10.3844/AJISP.2010.54.61
Understand the Role of Natural Killer
H. Lam (2010)
Novel pathomechanisms in chronic fatigue syndrome/myalgic encephalomyelitis: do purinergic signalling perturbations and gliosis play a role?
D. Staines (2010)
10.2174/1874196700902010020
Subgrouping in Chronic Fatigue Syndrome Based on Actigraphy and Illness Severity
Mariya Zaturenskaya (2009)
10.1186/1479-5876-8-1
Immune and hemorheological changes in Chronic Fatigue Syndrome
E. Brenu (2009)
Syndrome de fatigue chronique. Diagnostic, traitement et organisation des soins
E. Masquelier (2008)
10.1016/j.tox.2008.01.022
Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME).
R. Dietert (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar