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Single-walled And Multi-walled Carbon Nanotubes Promote Allergic Immune Responses In Mice.
U. Nygaard, J. S. Hansen, M. Samuelsen, T. Alberg, C. Marioara, M. Løvik
Published 2009 · Chemistry, Medicine
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The adjuvant effect of particles on allergic immune responses has been shown to increase with decreasing particle size and increasing particle surface area. Like ultrafine particles, carbon nanotubes (CNTs) have nano-sized dimensions and a large relative surface area and might thus increase allergic responses. Therefore, we examined whether single-walled (sw) and multi-walled (mw) CNTs have the capacity to promote allergic responses in mice, first in an sc injection model and thereafter in an intranasal model. Balb/cA mice were exposed to three doses of swCNT, mwCNT, as well as ultrafine carbon black particles (ufCBPs, Printex90) during sensitization with the allergen ovalbumin (OVA). Five days after an OVA booster, OVA-specific IgE, IgG1, and IgG2a antibodies in serum and the numbers of inflammatory cells and cytokine levels in bronchoalveolar lavage fluid (BALF) were determined. Furthermore, ex vivo OVA-induced cytokine release from mediastinal lymph node (MLN) cells was measured. In separate experiments, differential cell counts were determined in BALF 24 h after a single intranasal exposure to the particles in the absence of allergen. We demonstrate that both swCNT and mwCNT together with OVA strongly increased serum levels of OVA-specific IgE, the number of eosinophils in BALF, and the secretion of Th2-associated cytokines in the MLN. On the other hand, only mwCNT and ufCBP with OVA increased IgG2a levels, neutrophil cell numbers, and tumor necrosis factor-alpha and monocyte chemoattractant protein-1 levels in BALF, as well as the acute influx of neutrophils after exposure to the particles alone. This study demonstrates that CNTs promote allergic responses in mice.
This paper references
Health Effects of Fine Particulate Air Pollution: Lines that Connect
J. Chow (2006)
Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children.
V. Morgenstern (2008)
Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis.
A. Shvedova (2008)
Y Sato (2005)
The degree and kind of agglomeration affect carbon nanotube cytotoxicity.
P. Wick (2007)
Nanotechnology safety concerns revisited.
S. Stern (2008)
Popliteal lymph node (PLN) assay to study adjuvant effects on respiratory allergy.
M. Løvik (2007)
Diesel exhaust particles and carbon black have adjuvant activity on the local lymph node response and systemic IgE production to ovalbumin.
M. Løvik (1997)
The effect of particles on allergic immune responses.
B. Granum (2002)
Carbon nanotubes and other fullerene nanocrystals in domestic propane and natural gas combustion streams.
J. J. Bang (2004)
Fine particles are more strongly associated than coarse particles with acute respiratory health effects in schoolchildren.
J. Schwartz (2000)
Combustion-generated nanoparticulates in the El Paso Their comparative characterization and potential for adverse health effects
L E Murr (2006)
NANOTUBES AND ALLERGY
The capacity of particles to increase allergic sensitization is predicted by particle number and surface area, not by particle mass.
U. Nygaard (2004)
Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron.
V. Kagan (2006)
Antioxidant Enzyme Induction: A New Protective Approach Against the Adverse Effects of Diesel Exhaust Particles
J. Wan (2007)
Anatomy and nomenclature of murine lymph nodes: Descriptive study and nomenclatory standardization in BALB/cAnNCrl mice.
W. Van den Broeck (2006)
Complement activation and protein adsorption by carbon nanotubes.
Carolina Salvador-Morales (2006)
Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma.
Jessica P. Ryman-Rasmussen (2009)
Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation.
C. Lam (2004)
Ultrafine particles in urban air and respiratory health among adult asthmatics.
P. Penttinen (2001)
Combustion-Generated Nanoparticulates in the El Paso, TX, USA / Juarez, Mexico Metroplex: Their Comparative Characterization and Potential for Adverse Health Effects
L. Murr (2006)
Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity.
C. de Haar (2008)
Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects.
J. Muller (2008)
Respiratory toxicity of multi-wall carbon nanotubes.
J. Muller (2005)
Residential proximity fine particles related to allergic sensitisation and asthma in primary school children.
I. Annesi-Maesano (2007)
Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies
K. Powers (2007)
Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types
L. Renwick (2004)
Nanotoxicology: Nanotechnology grows up
R F Service (2004)
Ultrafine carbon black particles cause early airway inflammation and have adjuvant activity in a mouse allergic airway disease model.
C. de Haar (2005)
A comparison of dispersing media for various engineered carbon nanoparticles
Mary C. Buford (2007)
Categorization framework to aid exposure assessment of nanomaterials in consumer products
S. Hansen (2008)
Complement activation and protein adsorption by carbon
C. Salvador-Morales (2006)
Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice.
H. Takano (1997)
Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo.
Y. Sato (2005)
Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model.
R. Mercer (2008)
Complement activation and protein adsorption by carbon
C. Salvador-Morales (2006)
Particle Size Determines Activation of the Innate Immune System in the Lung
M. Samuelsen (2009)
Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials.
D. Dutta (2007)
Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co‐administered antigen in mice
C. de Haar (2006)
ADSORPTION OF GASES IN MULTIMOLECULAR LAYERS
S. Brunauer (1938)
Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: physicochemical aspects.
I. Fenoglio (2008)
Respiratory effects are associated with the number of ultrafine particles.
A. Peters (1997)
Airborne house dust elicits a local lymph node reaction and has an adjuvant effect on specific IgE production in the mouse.
H. Ormstad (1998)
Effects of nano particles on antigen-related airway inflammation in mice
K. Inoue (2005)
The role of pollutants in allergic sensitization and the development of asthma
S. Parnia (2002)
IgE Adjuvant Activity of Particles—What Physical Characteristics are Important?
B. Granum (2000)
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Tumor immune microenvironment and nano-immunotherapeutics in colorectal cancer.
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V. Ramchandran (2019)
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