Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Apoptosis: Its Nature And Implications For Dermatopathology

D. Weedon, J. Searle, J. Kerr
Published 1979 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Apoptosis is a distinctive mode of cell death with characteristic morphologic features which serves as a balance to mitosis in regulating the size of animal tissues. In contrast to coagulative necrosis, the cytologic features of apoptosis suggest active self-destruction rather than progressive disintegration. It typically affects scattered individual cells which condense and bud to produce many membrane-bounded fragments in which organelles appear intact when viewed by the electron microscope. These apoptotic bodies are then phagocytosed and digested by cells resident in the tissue. Apoptosis, unlike coagulative necrosis, does not itself evoke an inflammatory response. Apoptosis is a feature of such diverse processes as deletion of phylogenetic vestiges during normal embryonic development, involution of endocrine-dependent organs after withdrawal of trophic hormones, cell-mediated immune attack on tissues, and therapeutically induced regression of neoplasms.Apoptosis has received scant attention in dermatopathology. However, it is now known to be an important feature of lichen planus, certain drug eruptions, the skin lesions of graft-versus-host reactions, the regression of plane warts, and the effects of ultraviolet damage. It is also involved in the kinetics of cutaneous neoplasms. In some of these situations, apoptotic bodies have, in the past, been given names such as Civatte bodies, colloid bodies, single-cell necrobiosis, sunburn cells, and dyskeratotic cells without their basic nature having been recognized.



This paper is referenced by
10.1111/j.1751-1097.1995.tb02344.x
ULTRAVIOLET‐INDUCED CELL DEATH IS INDEPENDENT OF DNA REPLICATION IN RAT KANGAROO CELLS
E. Miyaji (1995)
10.1111/j.1440-0960.1988.tb00367.x
THE CUTANEOUS HYALINOSES: DIFFERENTIAL DIAGNOSIS
M. Black (1988)
Identification of the biochemical signalling mechanisms underlying CD40 killing in colorectal cancer cells
A. Mohamed (2014)
Apoptotic and antiproliferative effects of fumonisin B l in human keratinocytes , fibroblasts , esophageal epithelial cells and hepatoma cells
W. Tolleson (2005)
10.1038/labinvest.3700133
Differential role of neutrophils and monocytes during subcutaneous plasma extravasation
K. Tokita (2004)
10.4103/0378-6323.97351
Solar ultraviolet radiation induces biological alterations in human skin in vitro: relevance of a well-balanced UVA/UVB protection.
F. Bernerd (2012)
Salivary TNF-α and sCD44 as Markers for Disease Activity and Malignant Transformation in Oral Lichen Planus
F. Zahran (2015)
10.1097/00000372-199608000-00002
Detection of apoptosis by in situ labeling in pilomatricoma.
S. Kishimoto (1996)
Clinical and |aboratorv sludies Eosinophilic globules in the Spitz nevus
S. Arbuckle (1982)
10.5794/JJOMS.43.693
Immunohistochemistry of Fas antigen
Yukoh Muraki (1997)
10.1016/S0091-679X(08)61921-4
Anatomical methods in cell death.
J. Kerr (1995)
10.1007/978-1-4757-9534-9
Macrophages and Related Cells
M. Horton (1993)
10.1111/j.1346-8138.1995.tb03945.x
Apoptosis Identified by DNA Fragmentation in Epidermal Neoplasms
O. Mori (1995)
10.1046/J.1523-1747.1999.00757.X
Evaluation of apoptotic cells induced by ultraviolet light B radiation in epidermal sheets stained by the TUNEL technique.
H. Okamoto (1999)
10.4049/jimmunol.182.1.711
Involvement of the Apoptotic Mechanism in Pemphigus Foliaceus Autoimmune Injury of the Skin1
N. Li (2009)
10.1080/09553009114550891
Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis.
S. Martin (1991)
10.1111/j.1440-1746.1987.tb00152.x
The significance of cell death by apoptosis in hepatobiliary disease
J. Searle (1987)
10.1074/JBC.M300574200
Epidermal Growth Factor Receptor-dependent, NF-κB-independent Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Inhibits Ultraviolet Irradiation-induced Caspases-3, -8, and -9 in Human Keratinocytes*
H. Q. Wang (2003)
10.2220/BIOMEDRES.30.201
Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-epigallocatechin-3-O-gallate in HL-60 cells.
Norihisa Okada (2009)
Apopitoz ve Dermatolojideki Önemi APOPTOSIS AND ITS IMPORTANCE IN DERMATOLOGY
T. Oskay (2008)
10.1290/1071-2690(2001)037<0283:UOOEOD>2.0.CO;2
ULTRASTRUCTURAL OBSERVATIONS ON EFFECTS OF DIFFERENT CONCENTRATIONS OF CALCIUM AND THYROXINE IN VITRO ON LARVAL EPIDERMAL CELLS OF RANA CATESBEIANA TADPOLES
J. Menon (2001)
10.1562/0031-8655(2001)073<0499:TADRUB>2.0.CO;2
Time and Dose-related Ultraviolet B Damage in Viable Pig Skin Explants Held in a Newly Developed Organ Culture System¶
J. Rijnkels (2001)
10.2131/jts.40.71
Characterization of nicardipine hydrochloride-induced cell injury in human vascular endothelial cells.
Masanori Ochi (2015)
10.1016/S0923-1811(98)00007-3
In situ labelling of fragmented DNA in cutaneous necrotizing vasculitis.
S. Barduagni (1998)
10.1002/JBMR.5650090511
Production and release of matrix vesicles in the cell processes of TPA‐treated human osteoblast‐like cells
T. Ringbom-Anderson (1994)
10.1083/JCB.138.2.449
Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell Line
M. Mancini (1997)
10.1111/j.1600-0560.1998.tb01705.x
Apoptosis and cellular proliferation in human epidermal squamous cell neoplasia
T. Makino (1998)
10.1254/JPHS.FP0072035
Characteristics of gabexate mesilate-induced cell injury in porcine aorta endothelial cells.
Tomoko Aki (2008)
10.1001/ARCHDERM.1986.01660180061015
Plane warts under spontaneous regression. Immunopathologic study on cellular constituents leading to the inflammatory reaction.
K. Iwatsuki (1986)
10.1007/BF02577544
Ultrastructural observations on effects of different concentrations of calcium and thyroxine in vitro on larval epidermal cells ofRana catesbeiana tadpoles
J. Menon (2007)
10.1111/j.1365-2559.1986.tb02590.x
Apoptotic bodies and abnormally dividing epithelial cells in squamous cell carcinoma
N. el-Labban (1986)
10.1111/j.1600-0560.1990.tb00059.x
Immunoelectron microscopic study of the basement membrane in oral lichen planus
P. Jungell (1990)
See more
Semantic Scholar Logo Some data provided by SemanticScholar