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DOI: 10.1097/00000542-197201000-00013

The Effects Of Ketamine On Cerebral Circulation And Metabolism In Man

H. Takeshita, Y. Okuda, A. Sari
Published 1972 · Medicine

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The effects of ketamine on cerebral circulation and metabolism were studied in ten healthy patients before elective surgical operations. With intravenous administration of ketamine in two increments (3 mg/kg total), cerebral blood flow increased from a control value of 47 to 76 ml/100 g/min and cerebral vascular resistance decreased from 1.91 to 1.38 mm Hg/ml/100 g/min. Cerebral perfusion pressure and PaCO2 increased from 88 to 102 mm Hg and from 36.0 to 39.7 mm Hg, respectively, after ketamine. These data indicate that the increase in cerebral blood flow was mainly the result of cerebral vasodilation caused by ketamine. CMRO2, CMRglucose, and CMRlactate as indices of cerebral metabolism did not change significantly after ketamine.



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