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Effects Of Dantrolene On Rat Diaphragm Muscle During Postnatal Maturation

G. Orliaguet, O. Langeron, C. Coirault, S. Fratea, P. Coriat, B. Riou
Published 2001 · Medicine

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Background Dantrolene is the only known effective treatment for malignant hyperthermia. However, its effects on diaphragm muscle during postnatal maturation remain unknown. Methods The effects of dantrolene (10−8 to 10−4 m) were investigated in vitro on diaphragm muscle strips in adult rats and in postnatal rats aged 3, 10, and 17 days, and compared with those of ryanodine (10−8 to 10−6 m). The authors studied contraction and relaxation under isotonic and isometric conditions (29°C, Krebs-Henseleit solution, tetanic stimulation at 50 Hz). Data are mean ± SD. Results During postnatal maturation, the authors observed a progressive increase in active force developed per cross- sectional area (from 34 ± 25 to 69 ± 32 mN/mm2;P < 0.05) and maximum shortening velocity (from 2.9 ± 0.5 to 4.9 ± 1.4 Lmax/s;P < 0.05). Dantrolene induced a negative inotropic effect in diaphragm muscles in isotonic and isometric conditions in all groups, but this effect was significantly less marked in the 3-day-old rats compared with older rats. Dantrolene did not induce significant lusitropic effects during postnatal maturation. Developmental changes in the pharmacologic response to dantrolene were more rapid than those of ryanodine. Conclusion Dantrolene induced less pronounced negative inotropic effects on the diaphragm in neonatal rats as compared with adult rats. Our study suggests that developmental changes in the pharmacologic response to dantrolene are more rapid than those of ryanodine.
This paper references
Development of histochemical and functional properties of baboon respiratory muscles.
L. C. Maxwell (1983)
Developmental changes in diaphragm contractile properties.
B. J. Moore (1993)
Similar inhibitory effects of dantrolene sodium on twitch tension and on silver ion-induced contracture in skeletal muscle.
T. Oba (1987)
Activity, molecular forms, and cytochemistry of cholinesterases in developing rat diaphragm
M. Brzin (1981)
An enzyme-histochemical, ultrastructural and morphometric study on fetal and neonatal rat diaphragms.
P. Poggi (1990)
Inhibitory action of dantrolene on Ca-induced Ca2+ release from sarcoplasmic reticulum in guinea pig skeletal muscle.
Ohta Toshio (1990)
Developmental transitions in the myosin heavy chain phenotype of human respiratory muscle.
J. Lloyd (1996)
Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles
F. Bertocchini (1997)
Postnatal expression of myosin lsoforms in the genioglossus and diaphragm muscles.
B. Brozanski (1993)
Complex pharmacology of malignant hyperthermia (editorial)
N Pessah (1996)
Mechanical determinants of isotonic relaxation in isolated diaphragm muscle.
C. Coirault (1993)
Clinically significant muscle weakness induced by oral dantrolene sodium prophylaxis for malignant hyperthermia.
C. B. Watson (1986)
Developmental changes in crossbridge properties and myosin isoforms in hamster diaphragm.
C. Coirault (1997)
Contractile properties of the developing diaphragm correlate with myosin heavy chain phenotype.
B. Johnson (1994)
Expression of the Ryanodine Receptor Type 3 Calcium Release Channel during Development and Differentiation of Mammalian Skeletal Muscle Cells*
P. Tarroni (1997)
Temporal differences in the induction of dihydropyridine receptor subunits and ryanodine receptors during skeletal muscle development.
J. Kyselovič (1994)
Inhibitory action of dantrolene on Ca-induced Ca2+ release from sarcoplasmic reticulum in guinea pig skeletal muscle.
T. Ohta (1990)
Effects of dantrolene on myoplasmic free [Ca2+] measured in vivo in patients susceptible to malignant hyperthermia.
J. R. López (1992)
Effects of dantrolene on the diaphragm muscle of the normal and myopathic hamster.
O. Langeron (1998)
Muscle structure and theories of contraction.
A. Huxley (1957)
The postnatal development and growth of the human lung. I. Morphometry.
T. Zeltner (1987)
How is ventilation maintained in the presence of the muscle relaxant, dantrolene sodium? A study in the anaesthetized rat
R. Farquhar (1986)
Isotonic contractile and fatigue properties of developing rat diaphragm muscle.
W. Z. Zhan (1998)
Dantrolene Inhibition of Sarcoplasmic Reticulum Ca2+Release by Direct and Specific Action at Skeletal Muscle Ryanodine Receptors*
B. Fruen (1997)
[Postoperative respiratory depression thought to be due to oral dantrolene pretreatment in a malignant hyperthermia-susceptible patient].
Y. Hara (1988)
Myosin isoforms in neonatal rat extensor digitorum longus, diaphragm, and soleus muscles.
W. LaFramboise (1990)
Oxidative potential in developing rat diaphragm, EDL, and soleus muscle fibers.
D. Smith (1988)
Developmental pattern of muscle fiber types in human ventilatory muscles.
T. Keens (1978)
Identification of Dantrolene Binding Sites in Porcine Skeletal Muscle Sarcoplasmic Reticulum (*)
J. Parness (1995)
The pharmacology of ryanodine and related compounds.
J. Sutko (1997)
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.
A. Ward (1986)
Effect of dantrolene on ventilation and respiratory muscle activity in anaesthetized dogs.
A. Oliven (1990)
Isometric relaxation of isolated diaphragm muscle: influence of load, length, time, and stimulation.
C. Coirault (1994)
Development of the mechanical properties of the respiratory system, Development of the Lung
AC Bryan (1977)
Metabolic and contractile protein expression in developing rat diaphragm muscle
A. Kelly (1991)
Rat diaphragm during postnatal development. II. Resistance to low- and high-frequency fatigue.
M. Fratacci (1996)
The effects of dantrolene sodium on cardiac and skeletal muscle in rats.
M. Meyler (1976)
Dantrolene Sodium Can Increase or Attenuate Activity of Skeletal Muscle Ryanodine Receptor Calcium Release Channel: Clinical Implications
T. Nelson (1996)
Effect of ryanodine on neonatal and adult rat heart: developmental increase in sarcoplasmic reticulum function.
H. Tanaka (1989)
Complex pharmacology of malignant hyperthermia.
I. Pessah (1996)
Effects of aging and obesity on respiratory muscle phenotype in Zucker rats.
S. Powers (1996)

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G. Orliaguet (2004)
Effects of halothane and isoflurane on the contraction, relaxation and energetics of rat diaphragmatic muscle.
B. Bouhemad (2002)
Hyperthermie de l'adulte et coup de chaleur
P. Hausfater (2007)
Differential effects of post-natal development, animal strain and long term recovery on the restoration of neuromuscular function after neuromyotoxic injury in rat.
A. Vignaud (2006)
Diaphragmatic function is enhanced in fatty and diabetic fatty rats
A. De Jong (2017)
Effects of postnatal maturation on energetics and cross-bridge properties in rat diaphragm.
G. Orliaguet (2002)
Ontogenetic peculiarities of the effect of dantrolene and caffeine on the cardiac, respiratory and motor performance of intact and poisoned by physostigmine of rats
S. V. Kuznetsov (2020)
Current concepts in malignant hyperthermia.
J. Finsterer (2002)
Dantrolene and heatstroke: a good molecule applied in an unsuitable situation
P. Hausfater (2005)
Differential effects of right and left heart failure on skeletal muscle in rats.
Fabienne Knapp (2020)
cross-bridge properties in rat diaphragm Effects of postnatal maturation on energetics and
O. Langeron (2015)
Effects of Huperzin‐A on the Beta‐amyloid accumulation in the brain and skeletal muscle cells of a rat model for Alzheimer’s disease
C. H. Turkseven (2017)
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