Online citations, reference lists, and bibliographies.
← Back to Search

Porous Hydroxyapatite And Tricalcium Phosphate Cylinders With Two Different Pore Size Ranges Implanted In The Cancellous Bone Of Rabbits. A Comparative Histomorphometric And Histologic Study Of Bony Ingrowth And Implant Substitution.

P. Eggli, W. Müller, R. Schenk
Published 1988 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
To investigate the histophysiology of implant degradation, hydroxyapatite and tricalcium phosphate cylinders with a diameter of 3 mm were implanted in the cancellous bone of the distal femur and the proximal tibia of 15 New Zealand White rabbits for up to six months. All implants had a homogeneous pore distribution and a porosity of 60%. Ceramics with a pore size range of 50-100 micron and 200-400 micron were compared. Morphometric analysis showed that up to 85.4% of the originally implanted tricalcium phosphate was degraded after six months, whereas the volume reduction of the hydroxyapatite was only 5.4% after the same period. Within the first months bone and tissue ingrowth and implant resorption occurred at a higher rate in the smaller-pored tricalcium phosphate than in the larger-pored material. Hydroxyapatite cylinders with small pores were totally infiltrated by bone or bone marrow after four months, whereas in the larger-pored hydroxyapatite implants tissue did not penetrate all pores after six months and the amount of bone within the implant was small. Scanning electron microscopy of the material before implantation revealed the existence of numerous pore interconnections with diameters of about 20 micron in the smaller-pored ceramics. Such interconnections were rare in the larger-pored implants. The pore interconnections seem to promote vascular and tissue ingrowth and consequently the initial rate of implant resorption. Implant resorption is an active process and involves two different cell types. Acid phosphatase-positive osteoclast-like cells suggesting active resorption adhere directly to the surface, especially in tricalcium phosphate implants. Clusters of macrophages tightly packed with granular material are found in the pores and along the perimeter of all implant cylinders. They may play an active role in the intracellular degradation of small detached ceramic particles.



This paper is referenced by
10.1134/S0036029521040339
Fabrication of Calcium Phosphate Bioceramics with a Uniform Distribution of Pores of a Given Size
S. Tikhonova (2021)
10.3390/ma13163458
Physical/Chemical Properties and Resorption Behavior of a Newly Developed Ca/P/S-Based Bone Substitute Material
Bingchen Yang (2020)
10.1155/2020/8202873
Management of Discolored Failure Root Canal-Treated Upper Lateral Incisor
Nik Rozainah (2020)
10.1016/b978-0-08-102680-9.00010-x
Biointegration of bone graft substiutes from osteointegration to osteotranduction
F. Fernandez (2020)
10.1016/j.actbio.2020.06.022
β-Tricalcium Phosphate for Bone Substitution: Synthesis and Properties.
M. Bohner (2020)
10.1016/b978-0-08-102478-2.00006-4
Synthetic bone graft substitutes: Calcium-based biomaterials
A. Diez-Escudero (2020)
10.3906/biy-2002-19
In vitro tooth-shaped scaffold construction by mimicking late bell stage
P. N. Taşlı (2020)
10.3389/fbioe.2020.00061
Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing
L. Vidal (2020)
10.1016/j.msec.2020.110641
The response of host blood vessels to graded distribution of macro-pores size in the process of ectopic osteogenesis.
Jin-yu Li (2020)
10.1007/s00170-020-06397-1
3D printed composite materials for craniofacial implants: current concepts, challenges and future directions
S. Jindal (2020)
10.1016/j.ceramint.2020.03.192
A review of bioceramic porous scaffolds for hard tissue applications: Effects of structural features
Hossein Jodati (2020)
10.3390/biom10060887
Jaw Periosteal Cells Seeded in Beta-Tricalcium Phosphate Inhibit Dendritic Cell Maturation
J. Dai (2020)
10.1016/J.JMRT.2020.09.052
Investigation on preparation porous titanium through calciothermic reduction of porous TiO precursors
Zhijun Wang (2020)
10.1134/S2075113319050277
Stereolithographic 3D Printing of Bioceramic Scaffolds of a Given Shape and Architecture for Bone Tissue Regeneration
V. I. Putlyaev (2019)
10.1088/1748-605X/ab5f9c
Fast dissolving glucose porogens for early calcium phosphate cement degradation and bone regeneration.
Eline-Claire Grosfeld (2019)
10.1016/J.CERAMINT.2019.08.208
Novel silicon-wollastonite based scaffolds for bone tissue engineering produced by selective laser melting
N. Kamboj (2019)
10.17116/otorino20198401178
[Application of bone-plastic materials for mastoidoplasty].
F. Semenov (2019)
10.1186/s40824-019-0157-y
Review of bone graft and bone substitutes with an emphasis on fracture surgeries
Hoon-Sang Sohn (2019)
10.1016/j.mvr.2019.103925
Angiogenic effects of mesenchymal stem cells in combination with different scaffold materials.
P. Jehn (2019)
10.1016/j.micron.2019.102730
Human macrophages and osteoclasts resorb β-tricalcium phosphate in vitro but not mouse macrophages.
B. Arbez (2019)
10.1002/term.2801
Gas‐foamed poly(lactide‐co‐glycolide) and poly(lactide‐co‐glycolide) with bioactive glass fibres demonstrate insufficient bone repair in lapine osteochondral defects
Eve Salonius (2019)
10.4103/jcd.jcd_418_19
Histological evaluation of pulpal response to direct pulp capping using statins with α-tricalcium phosphate and mineral trioxide aggregate in human teeth
K. Mahendran (2019)
10.1089/ten.TEB.2018.0119
Advances in Porous Scaffold Design for Bone and Cartilage Tissue Engineering and Regeneration.
A. Cheng (2019)
The Challenge of Articular Cartilage Repair : Studies on Cartilage Repair in Animal Models and in Cell Culture
Eve Salonius (2019)
10.1007/978-3-319-33037-2_30-1
Mechanical Implant Material Selection, Durability, Strength, and Stiffness
Robert E. Sommerich (2019)
10.3390/jcm8101714
Nurse’s A-Phase–Silicocarnotite Ceramic–Bone Tissue Interaction in a Rabbit Tibia Defect Model
Belén Ñíguez Sevilla (2019)
10.3390/app9183674
Continuum Modeling and Simulation in Bone Tissue Engineering
J. A. Sanz-Herrera (2019)
Development of a composite tissue engineered alveolar bone-mucosal model using conventional and 3D printed scaffolding techniques
Thafar Almela (2018)
10.1007/5584_2018_249
Mesenchymal Stem Cells and Calcium Phosphate Bioceramics: Implications in Periodontal Bone Regeneration.
Carola Millán (2018)
10.1016/J.FDJ.2018.08.002
Open sinus lift surgery and augmentation with (SCPC versus H.A): A systematic review
Ahmed Zekry (2018)
The characterisation of adipose derived stem cells on coralline scaffolds for bone tissue engineering
Krishneel Singh (2018)
10.3892/etm.2017.5424
Effect of intermittent administration of teriparatide on the mechanical and histological changes in bone grafted with β-tricalcium phosphate using a rabbit bone defect model
Jun Komatsu (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar