Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Biosynthetic Bone Grafting.
J. Lane, E. Tomin, M. Bostrom
Published 1999 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
The regeneration of bone remains an elusive yet important goal in the field of orthopaedic surgery. Despite its limitations, autogenous cancellous bone grafting continues to the most effective means by which bone healing is enhanced clinically. Biosynthetic bone grafts currently are being developed as an alternative to autogenous bone grafting. These grafts generally contain one or more of three critical components: (1) osteoprogenitor cells; (2) an osteoconductive matrix; and (3) osteoinductive growth factors. The importance of each of these components based on preclinical data supports their use in biosynthetic bone grafts. The use of growth factors such as bone morphogenetic proteins, transforming growth factor, platelet derived growth factor, and fibroblastic growth factor is reviewed in preclinical long bone defect and spinal fusion models. The use of bone marrow in preclinical and clinical settings is presented with specific emphasis given to the use of bone marrow as a source of osteoprogenitor cells and how the use of these cells can be enhanced with the use of bone morphogenetic protein-2. These data support the concept that although products that contain only one of the three key components of a bone graft may regenerate bone successfully, composites of the three key components will be more successful clinically.
This paper references
Effect of platelet-derived growth factor on tibial osteotomies in rabbits.
T. J. Nash (1994)
Fracture Healing Perspectives
D. J. Simmons (1985)
Initiation and enhancement of bone formation. A review.
J. Triffitt (1987)
Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone.
E. Johnson (1992)
Stimulation of endosteal bone formation by systemic injections of recombinant basic fibroblast growth factor in rats.
T. Nakamura (1995)
Spine update. The use of animal models to study spinal fusion.
J. Schimandle (1994)
Pulsating Electromagnetic Field Stimulates mRNA Expression of Bone Morphogenetic Protein-2 and -4
M. Nagai (1994)
Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model.
S. Cook (1994)
Evaluation of rhBMP‐2 With an OPLA Carrier in a Canine Posterolateral (Transverse Process) Spinal Fusion Model
H. Sandhu (1995)
Characterization of cells with osteogenic potential from human marrow.
S. Haynesworth (1992)
Bone morphogenetic proteins: from basic studies to clinical approaches.
T. Sakou (1998)
Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair.
J. Wozney (1998)
Basic fibroblast growth factor for stimulation of bone formation in osteoinductive and conductive implants
J. Wang (1996)
Growth factors and the regulation of bone remodeling.
E. Canalis (1988)
Evaluation of polylactic acid homopolymers as carriers for bone morphogenetic protein.
S. Miyamoto (1992)
Acidic fibroblast growth factor (aFGF) injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing
S. Jingushi (1990)
Novel regulators of bone formation: molecular clones and activities.
J. Wozney (1988)
In Vivo Evaluation of Recombinant Human Osteogenic Protein (rhOP-1) Implants As a Bone Graft Substitute for Spinal Fusions
S. Cook (1994)
Experimental Spinal Fusion With Recombinant Human Bone Morphogenetic Protein‐2
J. Schimandle (1995)
Increased mechanical strength of healing rat tibial fractures treated with biosynthetic human growth hormone.
B. Bak (1990)
Transforming growth factor-beta in the regulation of fracture repair.
M. E. Joyce (1990)
Immunohistochemical analysis of bone morphogenetic protein (BMP) in osteosarcoma.
Y. Jin (1990)
Role of Transforming Growth Factor‐β in Fracture Repair
M. E. Joyce (1990)
Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix
D. Ingber (1989)
The biology of hematopoietic stem cells.
S. Morrison (1995)
Current approaches to experimental bone grafting.
J. Lane (1987)
Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair.
J. Lane (1999)
Immunologic Responses in Human Recipients of Osseous and Osteochondral Allografts
D. Strong (1996)
Dose response of growth hormone on fracture healing in the rat.
B. Bak (1990)
Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
A. Celeste (1990)
The critical role of geometry of porous hydroxyapatite delivery system in induction of bone by osteogenin, a bone morphogenetic protein.
U. Ripamonti (1992)
Healing Bone Using Recombinant Human Bone Morphogenetic Protein 2 and Copolymer
C. A. Kirker-Head (1998)
Qualitative and quantitative analysis of orthotopic bone regeneration by marrow
J. R. Werntz (1996)
The effects of growth hormone on fracture healing in rats: a histological description.
L. Mosekilde (1993)
The aging of hematopoietic stem cells
S. Morrison (1996)
Potential role of insulinlike growth factors in fracture healing.
S. Trippel (1998)
Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation.
T. Sampath (1981)
Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells
M. Noda (1989)
Cervical Interbody Fusion Cages: An Animal Model With and Without Bone Morphogenetic Protein
T. Zdeblick (1998)
Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats.
T. Onishi (1998)
In vivo stimulation of bone formation by transforming growth factor-beta.
M. Noda (1989)
Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing
T. Nakase (1994)
Growth factor treatment of fractures.
T. Einhorn (1997)
Evaluation of Collagen Ceramic Composite Graft Materials in a Spinal Fusion Model
G. Muschler (1996)
Potential Role of Fibroblast Growth Factor in Enhancement of Fracture Healing
M. L. Radomsky (1998)
The Use of an Osteoinductive Growth Factor for Lumbar Spinal Fusion: Part II Study of Dose, Carrier, and Species
S. Boden (1995)
Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation.
D. Toriumi (1991)
Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells.
E. Wang (1993)
Osteogenetic activity in composite grafts of demineralized compact bone and marrow.
J. Wittbjer (1983)
Repair of bone defects with marrow cells and porous ceramic. Experiments in rats.
H. Ohgushi (1989)
Platelet-derived growth factor expression in normally healing human fractures.
J. Andrew (1995)
Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2).
R. Kenley (1994)
Expression of four growth factors during fracture repair.
W. Bourque (1993)
Role of bone substitutes.
J. Hollinger (1996)
Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.
P. Hauschka (1986)
The effect of growth hormone on the healing of experimental bone defects.
H. Herold (1971)
Transforming Growth Factor-β Gene Family Members and Bone*
M. Centrella (1994)
The Use of an Osteoinductive Growth Factor for Lumbar Spinal Fusion: Part I Biolog of Spinal Fusion
S. Boden (1995)
Rapid publication TGF‐β1 induces bone closure of skull defects
L. Beck (1991)
Effect of Growth Hormone on Skeletal Mass in Adult Dogs
WILLIAM H. Harris (1969)
Use of Bone Morphogenetic Protein-2 in the Rabbit Ulnar Nonunion Model
M. Bostrom (1996)
Morbidity at bone graft donor sites.
E. Younger (1989)
Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing
M. Bostrom (1995)
Bone morphogenetic protein induces bone in the squirrel monkey, but bone matrix does not.
P. Aspenberg (1992)
Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells.
M. Hurley (1993)
This paper is referenced by
Search Strategy We reviewed human studies published in international English language peer-reviewed literature regarding the treatment of osseous defects with Cell-Based Bone Tissue Engineering
Gert J. Meijer ()
Comparison of computed tomography and microradiography for graft evaluation after reconstruction of critical size bone defects using beta-tricalcium phosphate.
M. Nolff (2010)
Mini-midvastus Total Knee Arthroplasty
S. Haas (2010)
Increased stem cells delivered using a silk gel/scaffold complex for enhanced bone regeneration
X. Ding (2017)
Do autologous growth factors enhance transforaminal lumbar interbody fusion?
H. Hee (2003)
Ovine bone and marrow derived progenitor cells : isolation, characterization, and osteogenic potential
Johannes C. Reichert (2010)
In vivo performance of combinations of autograft, demineralized bone matrix, and tricalcium phosphate in a rabbit femoral defect model.
Jinku Kim (2014)
Comparison Between Polyurethanes Containing Castor Oil (Soft Segment) and Cancellous Bone Autograft in the Treatment of Segmental Bone Defect Induced in Rabbits
Oduvaldo Câmara Marques Pereira-Júnior (2007)
[Cellular strategies in bone tissue engineering: a review].
C. Trojani (2008)
Tissue-engineered collagen meniscus implants: 5- to 6-year feasibility study results.
J. Steadman (2005)
Minimal-invasive Knieendoprothetik in Tibia-first-Technik
A. Halder (2007)
Comparative study between coral-mesenchymal stem cells-rhBMP-2 composite and auto-bone-graft in rabbit critical-sized cranial defect model.
R. Hou (2007)
Regenerative Medicine: A New Paradigm in Bone Regeneration
Orlando Chaparro (2016)
Efficacy of tissue engineered bone grafts containing mesenchymal stromal cells for cleft alveolar osteoplasty in a rat model.
P. Korn (2014)
The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterials.
O. Chan (2012)
Repair of bone defects around dental implants with bone morphogenetic protein/fibroblast growth factor-loaded porous calcium phosphate cement: a pilot study in a canine model.
L. Wang (2011)
A CURRENT REVIEW ON THE BIOLOGY AND TREATMENT OF ARTICULAR CARTILAGE DEFECTS (PART I & PART II)
C. Willers (2003)
Hyperbaric oxygen therapy improves angiogenesis and bone formation in critical sized diaphyseal defects
J. P. Grassmann (2015)
The chemical composition of synthetic bone substitutes influences tissue reactions in vivo: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate ceramics.
S. Ghanaati (2012)
Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study.
Q. Cui (2006)
A novel technique to reconstruct a boxlike bone defect in the mandible and support dental implants with In vivo tissue-engineered bone.
JinFeng Yao (2009)
The effect of an alginate carrier on bone formation in a hydroxyapatite scaffold.
M. Coathup (2016)
Ectopic bone formation in and soft-tissue response to P(CL/DLLA)/bioactive glass composite scaffolds.
V. Meretoja (2014)
Optimized bone regeneration based on sustained release from three‐dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP‐2
Y. Fu (2008)
Process planning for the subtractive rapid manufacturing of heterogeneous materials: Applications for automated bone implant manufacturing
Shuangyan Lei (2014)
The bone morphogenic protein.
Richard Derner (2005)
Effect of Use of Slow Release of Bone Morphogenetic Protein-2 and Transforming Growth Factor-Beta-2 in a Chitosan Gel Matrix on Cranial Bone Graft Survival in Experimental Cranial Critical Size Defect Model
H. I. Canter (2010)
Antibacterial effects of sol-gel-derived bioactive glass nanoparticle on aerobic bacteria.
V. Mortazavi (2010)
Total Knee Replacement through a Mini-Mid-Vastus Approach
R. S. Laskin (2007)
Bone augmentation by replica-based bone formation.
M. Draenert (2020)
The role and effectiveness of bone marrow in osseous regeneration.
J. Block (2005)
Chemical, Structural & Osteoconductive Properties of Mineralized Porcine Cancellous Bone.
K. Sh (2001)See more