Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Nuclear β-Catenin Accumulation As Reliable Marker For The Differentiation Between Cystic Craniopharyngiomas And Rathke Cleft Cysts: A Clinico-Pathologic Approach

B. Hofmann, J. Kreutzer, W. Saeger, M. Buchfelder, I. Blümcke, R. Fahlbusch, R. Buslei
Published 2006 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Clinical and histopathologic differentiation of cystic lesions from the sellar region, that is, craniopharyngiomas (CPs) and Rathke cleft cysts (RCCs), is challenging and has paramount importance with respect to variable clinical manifestation and adapted surgical treatment strategies in both entities. Here, we retrospectively evaluated clinico-pathologic findings in 81 patients presenting with a cystic tumor located in the sellar region. All patients underwent transsphenoidal or transcranial resections. Microscopic inspection of surgical specimens identified CP in 51 patients, and RCC in 30 patients. Amongst the panel of immunohistochemical marker proteins used for histopathologic analysis, nuclear accumulation of β-catenin was detectable only in CP. On the basis of the histopathologic and immunohistochemical analysis, clinical presentation (sex, age, ophthalmologic, and endocrinologic deficits), imaging (tumor location, size, and calcification), as well as a description of cyst contents obtained during operation were retrospectively evaluated. In purely cystic CPs, an isointense signal was more frequent in T1-weighted magnetic resonance images and calcification of the tumor capsule in computed tomography scans. In addition, the size of RCC was smaller and this tumor entity was more often located within the sella. Aberrant (nuclear) immunohistochemical staining for β-catenin appeared, however, as most reliable factor for the differentiation between purely cystic CPs and RCCs, whereas tumor location, tumor size, and calcification of the tumor capsule were less consistent parameters. The data are compatible with distinct pathogenic pathways associated with these related histopathologic entities.
This paper references
Clinical, radiological and pathological features of patients with the Rathke’s cleft cysts: tumor that may recur
JJ Mukherjee (1997)
10.1097/00006254-200004000-00018
Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke's cleft cyst, and arachnoid cyst.
J. Shin (1999)
10.1097/00004728-199007000-00006
MR Appearance and Cyst Content of Rathke Cleft Cysts
S. Asari (1990)
10.1017/S0012162204000374
Outcome of craniopharyngioma in children: long-term complications and quality of life.
A. Poretti (2004)
10.3171/JNS.1980.52.5.0661
Transsphenoidal microsurgery in the management of craniopharyngioma.
E. Laws (1980)
10.3171/JNS.1990.73.1.0012
Correlation of clinical and pathological features in surgically treated craniopharyngiomas.
T. E. Adamson (1990)
10.1097/00019616-200207000-00008
Tumor-like Lesions of the Pituitary and Sellar Region
W. Saeger (2002)
10.1111/j.1365-2265.2005.02231.x
Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long‐term follow‐up
N. Karavitaki (2005)
MR imaging findings of Rathke's cleft cysts: significance of intracystic nodules.
W. M. Byun (2000)
10.1111/j.1365-2265.2004.02196.x
High prevalence of long‐term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma
A. Pereira (2005)
10.3171/JNS.1992.76.1.0047
Aggressive surgical management of craniopharyngiomas in children.
H. Hoffman (1992)
10.3171/JNS.2002.97.1.0003
Craniopharyngioma in adults and children: a study of 122 surgical cases.
R. van Effenterre (2002)
10.1159/000429882
Surgical treatment of craniopharyngiomas: an evaluation of the transsphenoidal and pterional approaches.
G. Maira (1995)
10.1007/s007010050482
MRI Findings and Clinical Manifestations in Rathke's Cleft Cyst
N. Saeki (1999)
10.1097/00006123-199801000-00003
Transsphenoidal management of 28 symptomatic Rathke's cleft cysts, with special reference to visual and hormonal recovery.
W. el-Mahdy (1998)
10.1007/s007010050315
Non-Neoplastic Cystic Lesions of the Sellar Region Presentation, Diagnosis and Management of Eight Cases and Review of the Literature
J. Iqbal (1999)
10.1097/00005537-200210000-00024
Rathke Cleft Cyst: Diagnostic and Therapeutic Considerations
J. Kasperbauer (2002)
10.1097/00006123-200002000-00007
Long-term outcomes for surgically resected craniopharyngiomas.
J. Duff (2000)
10.1007/s00401-005-1004-x
Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region
R. Buslei (2005)
10.1007/s11060-004-5232-z
β-catenin mutations in craniopharyngiomas and pituitary adenomas
E. Oikonomou (2004)
10.3171/JNS.1995.83.2.0206
Papillary craniopharyngioma: a clinicopathological study of 48 cases.
T. Crotty (1995)
10.1002/path.1562
Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma
K. Kato (2004)
Beta-catenin mutations in craniopharyngiomas and pituitary adenomas.
E. Oikonomou (2005)
10.3171/JNS.2004.101.4.0577
Surgery for Rathke cleft cysts: technical considerations and outcomes.
R. Benveniste (2004)
10.1097/00004728-198709000-00013
Craniopharyngioma: CT and MR imaging in nine cases.
M. Freeman (1987)
Tests of endocrine function for neurosurgical patients
R Fahlbusch (2000)
10.1016/S0002-9440(10)64477-X
Short Communication Craniopharyngiomas of Adamantinomatous Type Harbor -Catenin Gene Mutations
S. Sekine (2002)
CT and MRI imaging in nine cases
M P Freeman (1987)
Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations.
S. Sekine (2002)
10.3171/JNS.2005.102.2.0189
Surgical outcomes in 118 patients with Rathke cleft cysts.
Christopher J Aho (2005)
10.3171/JNS.1999.90.2.0237
Surgical treatment of craniopharyngiomas: experience with 168 patients.
R. Fahlbusch (1999)
10.1159/000120860
Craniopharyngioma: results of survey of the American Society of Pediatric Neurosurgery.
R. Sanford (1994)
10.1097/00006123-199410000-00008
Radiological study of symptomatic Rathke's cleft cysts.
H. Oka (1994)
10.3171/JNS.2005.102.4.0650
Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngioma.
Indro Chakrabarti (2005)
10.1210/JCEM.82.7.4043
Clinical, radiological and pathological features of patients with Rathke's cleft cysts: tumors that may recur.
J. Mukherjee (1997)
10.1097/00006123-199905000-00012
Transnasal surgery for infradiaphragmatic craniopharyngiomas in pediatric patients.
T. Abe (1999)
10.1007/s003810050108
Long-term results of treatment for craniopharyngioma in children
G. Tomei (1997)
10.5167/UZH-1853
MR differentiation of adamantinous and squamous-papillary craniopharyngiomas.
S. Sartoretti-Schefer (1997)
10.3171/JNS.1994.80.6.1018
Epithelial cystic lesions of the sellar and parasellar region: a continuum of ectodermal derivatives?
M. Harrison (1994)
10.3171/JNS.2002.96.4.0704
Surgical outcomes in 31 patients with craniopharyngiomas extending outside the suprasellar cistern: an evaluation of the frontobasal interhemispheric approach.
R. Shirane (2002)
10.1097/01.PAP.0000131826.54447.22
Only Adamantinomatous but Not Papillary Type of Craniopharyngioma Is Associated with ??-Catenin Mutation
W. Y. Tsang (2004)
10.1007/s007010170120
Immunohistochemical Localisation of Cytokeratins in Craniopharyngioma
M. Kurosaki (2001)
10.1227/00006123-199504000-00012
Surgical treatment of craniopharyngiomas: an evaluation of the transsphenoidal and pterional approaches.
G. Maira (1995)
10.3171/JNS.1999.90.2.0251
Surgical treatment of craniopharyngiomas: endocrinological results.
J. Honegger (1999)
10.1227/00006123-199202000-00004
Radiologic characteristics and results of surgical management of Rathke's cysts in 43 patients.
D. A. Ross (1992)
10.1159/000120863
Transsphenoidal removal of craniopharyngioma.
E. Laws (1994)
10.1007/BF01420500
Transnasal surgery in the treatment of craniopharyngiomas
A. Koenig (2005)
10.3171/JNS.2004.100.1.0033
Surgical treatment of symptomatic Rathke cleft cysts: clinical features and results with special attention to recurrence.
J. E. Kim (2004)
10.1001/ARCHNEURPSYC.1934.02250110061005
TUMORS OF RATHKE'S CLEFT: (HITHERTO CALLED TUMORS OF RATHKE'S POUCH)
C. Frazier (1934)
10.1046/j.1365-2133.2004.05811.x
β‐catenin expression in benign and malignant pilomatrix neoplasms
A. Hassanein (2004)
10.1227/00006123-199103000-00012
Results of transsphenoidal extirpation of craniopharyngiomas and Rathke's cysts.
A. Landolt (1991)



This paper is referenced by
10.1007/s00401-006-0184-3
Nuclear β-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas
R. Buslei (2006)
10.1016/j.stem.2013.07.004
Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.
C. Andoniadou (2013)
10.5772/31173
Diagnostic Evaluation of the Lesions of the Sellar and Parasellar Region
R. Attanasio (2012)
10.1073/pnas.1101553108
Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans
C. Gaston-Massuet (2011)
10.1007/978-3-030-41176-3
Adult Craniopharyngiomas: Differences and Lessons from Paediatrics
Emmanuel Jouanneau (2020)
10.1007/s10633-019-09713-7
Rathke’s cleft cyst presenting as incomplete cavernous sinus syndrome and disc edema: a case report with literature review
C. F. Chang (2019)
10.1007/s11102-015-0682-1
Histopathology and molecular characterisation of intrauterine-diagnosed congenital craniopharyngioma
V. Scagliotti (2015)
10.1007/s00428-009-0873-0
A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas
S. Burghaus (2009)
10.1007/s11102-018-0890-6
Can tissue biomarkers reliably predict the biological behavior of craniopharyngiomas? A comprehensive overview
R. Prieto (2018)
The endoscopic endonasal approach for the management of craniopharyngiomas.
D. Solari (2016)
Recent advances in molecular pathology of craniopharyngioma [version 1; peer review: 2 approved]
Karavitaki (2019)
10.1227/01.NEU.0000372918.68453.5B
Hormone Receptor Expression in Craniopharyngiomas: A Clinicopathological Correlation
B. Hofmann (2010)
10.1530/JOE-17-0258
Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis
S. Haston (2018)
10.1055/s-0037-1621738
Pediatric Craniopharyngiomas: A Primer for the Skull Base Surgeon
C. Graffeo (2018)
10.1016/B978-0-444-59602-4.00017-4
Rathke's cleft cyst.
Sarah J. Larkin (2014)
10.1007/978-90-481-8665-5_4
Diagnosing and Grading of Brain Tumors: Immunohistochemistry
H. Takei (2011)
10.1227/01.NEU.0000349923.24247.D1
PRIMARY SUPRASELLAR MALIGNANT TUMOR WITH ODONTOGENIC FEATURES: CASE REPORT
H. Nishioka (2009)
10.1007/978-3-030-41176-3_8
How to Manage Recurrent Craniopharyngiomas
L. Cavallo (2020)
10.1002/stem.2267
Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma
J. P. Martinez-Barbera (2016)
10.1210/jc.2019-01299
The Medical Therapy of Craniopharyngiomas: The Way Ahead.
K. Alexandraki (2019)
10.12688/f1000research.11549.1
Recent advances in molecular pathology of craniopharyngioma
Sarah J. Larkin (2017)
10.3109/02688690903576237
Expression of aberrant β-catenin and impaired p63 in craniopharyngiomas
J. Cao (2010)
10.1111/bpa.12498
Review of xanthomatous lesions of the sella
B. Kleinschmidt-DeMasters (2017)
10.4172/2161-0681.1000291
Brafv600e and Ctbn1 Mutational Study in Rathke's Cleft Cysts
M. Antonelli (2016)
10.1177/1066896913486695
Osteonectin Expression in Surrounding Stroma of Craniopharyngiomas
A. Ebrahimi (2013)
10.1007/s00701-011-1072-8
Prognostic factors of operated Rathke’s cleft cysts with special reference to re-accumulation and recommended surgical strategy
Y. Ogawa (2011)
10.1007/978-1-4939-1578-1_15
Central Nerve System
S. A. Kazmi (2015)
10.3171/2014.12.JNS14596
Characteristics of Rathke's cleft cyst based on cyst location with a primary focus on recurrence after resection.
S. Chotai (2015)
10.1007/s12672-010-0041-7
CTNNB1 Gene Mutations, Pituitary Transcription Factors, and MicroRNA Expression Involvement in the Pathogenesis of Adamantinomatous Craniopharyngiomas
M. L. Campanini (2010)
10.1016/j.mce.2016.10.005
Stem cells and their role in pituitary tumorigenesis
G. Carreno (2017)
10.1002/alr.22326
ICAR: endoscopic skull‐base surgery
E. Wang (2019)
10.1007/s00401-010-0642-9
Tumour cell migration in adamantinomatous craniopharyngiomas is promoted by activated Wnt-signalling
A. Hoelsken (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar