Pancreatic Carcinomas In A 60-Year, Institute-Based Autopsy Material With Special Emphasis Of Metastatic Pattern
Márta Blastik, Eva Plavecz, Attila Zalatnai
Published 2011 · Biology, Medicine
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To the Editor: T he incidence of the pancreatic cancer is steadily rising in many countries of world; however, these figures show significant differences. In the United States, a 3-fold increase was noted between 1920 and 1978, and nowadays, it ranks fourth among cancer mortality data. This tumor type is mostly diagnosed at advanced stage because of early and rapid spread and aggressive local infiltration; therefore, only 15% to 20% of patients are resectable. The overall 5-year survival rate is less than 5%; even after pancreaticoduodenectomy, the median survival still remains poor: 12 to 18 months. In Hungary, however, the mortality rate has increased by 16-fold during the last 60 years (1948: 1.1/100,000, 2008: 18/100,000), accounting for the highest rise in Europe. The clear explanation of this finding is still lacking. One of the possible explanations of this is that the biological behavior of the tumor has been changed; therefore, we have investigated the main clinicopathologic features and the metastatic pattern of this tumor during a 60-year period in our autopsy material.
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