← Back to Search
Notochord Induction Of Zebrafish Slow Muscle Mediated By Sonic Hedgehog.
C. S. Blagden, P. Currie, P. Ingham, S. Hughes
Published 1997 · Medicine, Biology
Download PDFAnalyze on Scholarcy
The patterning of vertebrate somitic muscle is regulated by signals from neighboring tissues. We examined the generation of slow and fast muscle in zebrafish embryos and show that Sonic hedgehog (Shh) secreted from the notochord can induce slow muscle from medial cells of the somite. Slow muscle derives from medial adaxial myoblasts that differentiate early, whereas fast muscle arises later from a separate myoblast pool. Mutant fish lacking shh expression fail to form slow muscle but do form fast muscle. Ectopic expression of shh, either in wild-type or mutant embryos, leads to ectopic slow muscle at the expense of fast. We suggest that Shh acts to induce myoblasts committed to slow muscle differentiation from uncommitted presomitic mesoderm.
This paper references
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo.
E. Martí (1995)
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
S. Krauss (1993)
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
O. Pourquié (1996)
Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.
M. Goulding (1994)
Initial steps of myogenesis in somites are independent of influence from axial structures.
E. Bober (1994)
Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo.
M. Ott (1991)
Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception.
M. Cho (1994)
How is myogenesis initiated in the embryo?
G. Cossu (1996)
Myogenic specification of somites is mediated by diffusible factors.
N. Buffinger (1995)
Developmentally regulated expression of three slow isoforms of myosin heavy chain: diversity among the first fibers to form in avian muscle.
S. Page (1992)
MyoD or Myf-5 is required for the formation of skeletal muscle
M. Rudnicki (1993)
Myogenesis in paraxial mesoderm: preferential induction by dorsal neural tube and by cells expressing Wnt-1.
H. Stern (1995)
Diversity of expression of engrailed-like antigens in zebrafish.
K. Hatta (1991)
Developmental modulation of myosin expression by thyroid hormone in avian skeletal muscle.
M. Gardahaut (1992)
Cell lineages generating axial muscle in the zebrafish embryo
C. Kimmel (1987)
Hedgehog, Transmitted along Retinal Axons, Triggers Neurogenesis in the Developing Visual Centers of the Drosophila Brain
Z. Huang (1996)
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.
M. J. Bitgood (1995)
Halves of epithelial somites and segmental plate show distinct muscle differentiation behavior in vitro compared to entire somites and segmental plate.
A. Gamel (1995)
Why are fetal muscles slow?
A. Kelly (1980)
Neural tube and notochord promote in vitro myogenesis in single somite explants.
H. Stern (1995)
Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish.
L. Solnica-Krezel (1996)
Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos.
E. Weinberg (1996)
A homeobox gene essential for zebrafish notochord development
W. Talbot (1995)
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
M. Hammerschmidt (1996)
The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation.
P. M. Rong (1992)
Mutations affecting somite formation and patterning in the zebrafish, Danio rerio.
F. V. van Eeden (1996)
Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation
M. Halpern (1993)
Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos
B. Ticho (1996)
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
A. Münsterberg (1995)
Muscle fiber pattern is independent of cell lineage in postnatal rodent development
S. Hughes (1992)
Ectopic Pax-3 Activates MyoD and Myf-5 Expression in Embryonic Mesoderm and Neural Tissue
M. Maroto (1997)
Mutations affecting the formation of the notochord in the zebrafish, Danio rerio.
J. Odenthal (1996)
Autonomy of differentiation in avian branchial somites and the influence of adjacent tissues.
T. Kenny-Mobbs (1987)
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
Y. Echelard (1993)
The fub-1 mutation blocks initial myofibril formation in zebrafish muscle pioneer cells.
A. Felsenfeld (1991)
Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo.
M. Teillet (1983)
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
C. Chiang (1996)
Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle.
S. Hughes (1993)
Generation of chick skeletal muscle cells in groups of 16 from stem cells
L. S. Quinn (1985)
The expression of slow myosin during mammalian somitogenesis and limb bud differentiation
E. Vivarelli (1988)
Sclerotome development and peripheral nervous system segmentation in embryonic zebrafish.
E. M. Morin-Kensicki (1997)
The origin of secondary myotubes in mammalian skeletal muscles: ultrastructural studies.
M. Duxson (1989)
Mammalian myoblasts become fast or slow myocytes within the somitic myotome
G. Dhoot (2004)
Regulation of patched by sonic hedgehog in the developing neural tube.
V. Marigo (1996)
Cell diversification within the myogenic lineage: In vitro generation of two types of myoblasts from a single myogenic progenitor cell
D. Schafer (1987)
no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.
S. Schulte-Merker (1994)
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish
P. Currie (1996)
Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.
O. Pourquié (1993)
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
A. Vortkamp (1996)
The role of positive and negative signals in somite patterning
A. Lassar (1996)
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
S. Tajbakhsh (1997)
Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites
R. Johnson (1994)
Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation.
S. Devoto (1996)
Sequence and expression of amphioxus alkali myosin light chain (AmphiMLC-alk) throughout development: implications for vertebrate myogenesis.
L. Holland (1995)
Developmental origins of skeletal muscle fibers: clonal analysis of myogenic cell lineages based on expression of fast and slow myosin heavy chains.
J. B. Miller (1986)
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
H. Roelink (1994)
Maturation of myogenic and chondrogenic cells in the presomitic mesoderm of the chick embryo.
M. George-Weinstein (1994)
Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity
J. Ericson (1996)
Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm.
G. Cossu (1996)
Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants.
M. Halpern (1995)
The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail.
A. Schier (1997)
Myoblasts transferred to the limbs of embryos are committed to specific fibre fates
J. DiMario (1993)
wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis.
M. Baylies (1995)
Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos.
M. Pownall (1996)
Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression.
K. Hatta (1990)
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.
S. Ekker (1995)
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
C. Fan (1994)
Myosin expression and specialization among the earliest muscle fibers of the developing avian limb.
M. Crow (1986)
Myogenic determination factor expression in the developing avian limb bud: an RT-PCR analysis.
J. Lin-Jones (1996)
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
D. M. Stone (1996)
Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy
C. Webster (1988)
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning.
J. Concordet (1996)
This paper is referenced by
The zebrafish diwanka gene controls an early step of motor growth cone migration.
J. Zeller (1999)
Differentiation of slow and fast fibers in tentacles of Sepia officinalis (Mollusca)
A. Grimaldi (2004)
Embryonic temperature and the relative timing of muscle-specific genes during development in herring (Clupea harengus L.).
G. K. Temple (2001)
Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo.
P. Ingham (2005)
Regulation de tissus musculaires par des polypeptides 'hedgehog', et formulations et utilisations associees
Chris S. Bladgen (1998)
Cooperation between Shh and IGF‐I in promoting myogenic proliferation and differentiation via the MAPK/ERK and PI3K/Akt pathways requires smo activity
D. Madhala-Levy (2012)
Myomesin is part of an integrity pathway that responds to sarcomere damage and disease
Kendal Prill (2019)
8 Somitogenesis in Zebrafish
S. Holley (1999)
A hedgehog homolog is involved in muscle formation and organization of Sepia officinalis (mollusca) mantle
A. Grimaldi (2008)
Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations
H. Flanagan-Steet (2005)
Hedgehog signaling in animal development: paradigms and principles.
P. Ingham (2001)
Development of the zebrafish organizer and notochord.
K. A. Thomas (2004)
White meat or dark?
A. E. Brent (2004)
Hedgehog can drive terminal differentiation of amniote slow skeletal muscle
X. Li (2004)
New insights into skeletal muscle development and growth in teleost fishes.
P. Rescan (2008)
Dynamics of embryo axis elongation in amniotes vs. anamniotes:the role of the notochord
Tomás Augusto Barreiros Pais de Azevedo (2009)
Chapter 8 Molecular Mechanisms of Myoblast Fusion Across Species
Adriana Simionescu (2011)
Sonic Hedgehog (SHH) specifies muscle pattern at tissue and cellular chick level, in the chick limb bud
D. Duprez (1999)
Multiple tissue interactions and signal transduction pathways control somite myogenesis.
A. Borycki (2000)
Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development
A. Maggs (2004)
Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest.
J. Minchin (2008)
Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
A. Richard (2011)
Skeletal myogenesis in the zebrafish and its implications for muscle disease modelling.
D. Gurevich (2015)
Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb
M. Ganassi (2014)
Zebrafish tbx-c functions during formation of midline structures.
T. Dheen (1999)
Limb Muscle Formation Signals 917 Involvement of Muscle Connective Tissue in Muscle Patterning
D. Duprez (2002)
Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling.
K. Lewis (1999)
Rapid evolution of muscle fibre number in post-glacial populations of Arctic charr Salvelinus alpinus
I. Johnston (2004)
Transcriptional analysis of mouse skeletal myofiber diversity and adaptation to endurance exercise
H. Wu (2004)
On best behavior: cadherins drive slow muscle to their limits.
M. Granato (2003)
Xenopus As Model Animals for Studying Larval to Adult Tissue Remodeling and Adult Organ Formation
Akio Nishikawa (2016)
Knockdown of Laminin gamma-3 (Lamc3) impairs motoneuron guidance in the zebrafish embryo
A. Eve (2017)See more