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The RLA1/SMOS1 Transcription Factor Functions With OsBZR1 To Regulate Brassinosteroid Signaling And Rice Architecture

Shenglong Qiao, Shiyong Sun, Linlin Wang, Z. Wu, Chengxiang Li, Xiaoming Li, T. Wang, L. Leng, W. Tian, Tiegang Lu, Xuelu Wang
Published 2017 · Medicine, Biology

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The RLA1/SMOS1 transcription factor acts as an integrator of the transcriptional complex directly downstream of the kinase GSK2 and plays an essential role in BR signaling and development in rice. Brassinosteroids (BRs) are plant-specific steroid hormones that control plant growth and development. Recent studies have identified key components of the BR signaling pathway in Arabidopsis thaliana and in rice (Oryza sativa); however, the mechanism of BR signaling in rice, especially downstream of GSK3/SHAGGY-like kinase (GSK2), remains unclear. Here, we identified a BR-insensitive rice mutant, reduced leaf angle1 (rla1), and cloned the corresponding gene. RLA1 was identical to the previously reported SMALL ORGAN SIZE1 (SMOS1), which was cloned from another allele. RLA1/SMOS1 encodes a transcription factor with an APETALA2 DNA binding domain. Genetic analysis indicated that RLA1/SMOS1 functions as a positive regulator in the BR signaling pathway and is required for the function of BRASSINAZOLE-RESISTANT1 (OsBZR1). In addition, RLA1/SMOS1 can interact with OsBZR1 to enhance its transcriptional activity. GSK2 can interact with and phosphorylate RLA1/SMOS1 to reduce its stability. These results demonstrate that RLA1/SMOS1 acts as an integrator of the transcriptional complex directly downstream of GSK2 and plays an essential role in BR signaling and plant development in rice.
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