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The Arabidopsis NIM1 Protein Shows Homology To The Mammalian Transcription Factor Inhibitor I Kappa B.
J. Ryals, K. Weymann, K. Lawton, L. Friedrich, D. Ellis, H. Steiner, J. Johnson, T. Delaney, T. Jesse, P. Vos, S. Uknes
Published 1997 · Biology, Medicine
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The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor I kappa B subclass alpha. NF-kappa B/I kappa B signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.
This paper references
Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance.
T. Delaney (1995)
Intron-exon structure of the porcine IκBα-encoding gene
R. Martin (1995)
Genetic Dissection of Acquired Resistance to Disease
T. Delaney (1997)
Biologically induced systemic acquired resistance in Arabidopsis thaliana
R. Cameron (1994)
Generation of a plasmid vector for deletion cloning by rapid multiple site-directed mutagenesis.
K. S. Bhat (1993)
J. T. Greenberg
Intron-exon structure of the porcine I kappa B alpha-encoding gene.
R. de Martin (1995)
Signals in plant disease
D. A. Dempsey (1995)
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
C. Y. Wang (1996)
994). lncreased disease susceptibility of transgenic 5
E A Maher
Plant Disease Resistance Genes: Function Meets Structure.
A. Bent (1996)
Coordinate increase in major transcripts from the high pI alpha-amylase multigene family in barley aleurone cells stimulated with gibberellic acid.
J. C. Rogers (1984)
Fast and sensitive multiple sequence alignments on a microcomputer
D. Higgins (1989)
Systemic acquired resistance signal transduction
M. Hunt (1996)
The CIC library: a large insert YAC library for genome mapping in Arabidopsis thaliana.
F. Creusot (1995)
Is Salicylic Acid a Translocated Signal of Systemic Acquired Resistance in Tobacco?
V. Shulaev (1995)
Assignment of 30 microsatellite loci to the linkage map of Arabidopsis.
C. Bell (1994)
Sequence of rat RUIF-I encoding an IKB
M. Tewari (1992)
Systemic acquired resistance in Arabidopsis thaliana induced by a predisposing infection with a pathogenic isolate of Fusarium oxysporum
B. Mauch-Mani (1994)
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.
S. Elledge (1991)
Splice site prediction in Arabidopsis thaliana pre-mRNA by combining local and global sequence information.
S. M. Hebsgaard (1996)
60 th amino - and carboxyl - terminal sequences within l ~ B a regulate its inducible degradation
S. Sun (1996)
Current Protocols in Molecular Biology
F. M. Ausubel (1987)
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
A. Beg (1996)
60th amino- and carboxyl-terminal sequences within l ~ B
S. Sun (1996)
Salicylic Acid Is Not the Translocated Signal Responsible for Inducing Systemic Acquired Resistance but Is Required in Signal Transduction.
B. Vernooij (1994)
Programmed cell death in plants: A pathogen-triggered response activated coordinately with multiple defense functions
J. Greenberg (1994)
Benzothiadiazole induces disease resistance in Arabidopsis by activation of the systemic acquired resistance signal transduction pathway.
K. Lawton (1996)
A model of evolutionary change in proteins
M. O. Dayhoff (1968)
Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation.
S. Sun (1996)
The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats
M. Mindrinos (1994)
Sequence of rat RUIF-I encoding an IKB, and comparison with related proteins containing notch-like repeats
M Tewari (1992)
lnhibition of NF - KB by sodium salicylate and aspirin
L. M. Lagrimini
Arabidopsis mutants simulating disease resistance response
R. Dietrich (1994)
Suppression of TNF - a - induced apoptosis by NF - kappaB
Van Antwerp Dj (1996)
Signals in plant disease resistance
D. A. Dempsey (1995)
The ANK repeat: a ubiquitous motif involved in macromolecular recognition.
P. Michaely (1992)
Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening.
J. Glazebrook (1996)
Production of Salicylic Acid Precursors Is a Major Function of Phenylalanine Ammonia-Lyase in the Resistance of Arabidopsis to Peronospora parasitica.
B. Mauch-Mani (1996)
A small-scale procedure for the rapid isolation of plant RNAs.
T. Verwoerd (1989)
The Molecular Biology of Systemic Acquired Resistance
T. Delaney (1993)
Generation of a high-quality P1 library of Arabidopsis suitable for chromosome walking
Y. Liu (1995)
ammonia-lyase expression do not develop systemic acquired resistance in response to infection by tobacco mosaic virus
J. E. Parker (1996)
Hydrogen peroxide does not function downstream of salicylic acid in the induction of PR protein expression.
Y. Bi (1995)
Molecular cloning of complementary DNA encoding the lignin-forming peroxidase from tobacco: Molecular analysis and tissue-specific expression.
L. M. Lagrimini (1987)
The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor
S. Whitham (1994)
Cytokine‐inducible expression in endothelial cells of an I kappa B alpha‐like gene is regulated by NF kappa B.
R. Martin (1993)
Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes.
J. Parker (1996)
Suppression of TNF-α-Induced Apoptosis by NF-κB
D. V. Van Antwerp (1996)
The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 and the tobacco viral resistance gene N.
G. Lawrence (1995)
Tobacco plants epigenetically suppressed in phenylalanine ammonia‐lyase expression do not develop systemic acquired resistance in response to infection by tobacco mosaic virus
J. Pallas (1996)
Increased disease susceptibility of transgenic tobacco plants with suppressed levels of preformed phenylpropanoid products.
E. Maher (1994)
struction and characterization of a bacterial artificial chromosome library of Arabidopsis thaliana
S. Choi (1995)
Basic local alignment search tool.
S. Altschul (1990)
The Arabidopsis NPR1 Gene That Controls Systemic Acquired Resistance Encodes a Novel Protein Containing Ankyrin Repeats
H. Cao (1997)
AFLP: a new technique for DNA fingerprinting.
P. Vos (1995)
lnhibition of NF-KB
E. Kopp (1994)
lncreased disease susceptibility of transgenic 5 , 151 - 153 . 753 - 763 . J . 10 , 71 - 82 . J . 4 , 745 - 750 . tobacco plants with suppressed levels of preformed phenylpro - panoid products
2,6-Dichloroisonicotinic acid-induced resistance to pathogens without the accumulation of salicylic acid
B. Vernooij (1995)
NDR1, a locus of Arabidopsis thaliana that is required for disease resistance to both a bacterial and a fungal pathogen.
K. C. Century (1995)
Dif, a dorsal-related gene that mediates an immune response in Drosophila
Y. T. Ip (1993)
Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.
M. Gribskov (1986)
745-750. tobacco plants with suppressed levels of preformed phenylpropanoid products
1s salicylic acid a translocated signal of systemic acquired resistance in tobacco? Plant Cell7
V Shulaev (1995)
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
B. Lemaître (1996)
Acquired resistance in Arabidopsis.
S. Uknes (1992)
A mutation in Arabidopsis that leads to constitu - 403 - 410 . 87 , 13 - 20 . tive expression of systemic acquired resistance
S. A. Bowling (1994)
Requirement of Salicylic Acid for the Induction of Systemic Acquired Resistance
T. Gaffney (1993)
Molecular cloning : a laboratory manual. Cold Spring Harbor, NY
H. Sambrook (1989)
Suppression and Restoration of Lesion Formation in Arabidopsis lsd Mutants.
K. Weymann (1995)
A mutation in Arabidopsis that leads to constitu-403-410
S A Bowling (1994)
Construction and characterization of a bacterial artificial chromosome library of Arabidopsis thaliana
S. Choi (1995)
tive expression of systemic acquired resistance
A mutation in Arabidopsis that leads to constitutive expression of systemic acquired resistance.
S. Bowling (1994)
Molecular Cloning: A Laboratory Manual
J. Sambrook (1983)
Characterization of an Arabidopsis Mutant That Is Nonresponsive to Inducers of Systemic Acquired Resistance.
H. Cao (1994)
Biological induction of systemic acquired resistance in Arabidopsis
S. Uknes (1993)
In planta Agrobacterium mediated gene transfer by infiltration of adult Arabidopsis thaliana plants
N. Bechtold (1993)
parasitica specified by severa1 different RPP genes
D. A. Patton (1991)
A Central Role of Salicylic Acid in Plant Disease Resistance
T. Delaney (1994)
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
A. Baldwin (1996)
Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with related proteins containing notch-like repeats [corrected].
M. Tewari (1992)
Recombinant inbred lines for mapping RFLP and phenotypic markers in Arabidopsis thaliana
C. Lister (1993)
This paper is referenced by
Pandemonium Breaks Out: Disruption of Salicylic Acid-Mediated Defense by Plant Pathogens.
G. Qi (2018)
Signals Involved in Arabidopsis Resistance toTrichoplusia ni Caterpillars Induced by Virulent and Avirulent Strains of the Phytopathogen Pseudomonas syringae 1
J. Cui (2002)
Arabidopsis WRKY70 is required for full RPP4-mediated disease resistance and basal defense against Hyaloperonospora parasitica.
Colleen Knoth (2007)
The Hypersensitive Response
T. Jabs (2000)
Salicylic acid induces rapid inhibition of mitochondrial electron transport and oxidative phosphorylation in tobacco cells
Expression of tobacco class II catalase gene activates the endogenous homologous gene and is associated with disease resistance in transgenic potato plants
D. Yu (2004)
Perception of low red:far-red ratio compromises both salicylic acid- and jasmonic acid-dependent pathogen defences in Arabidopsis.
Mieke de Wit (2013)
NPR1 preferentially binds to the DNA-inactive form of Arabidopsis TGA2.
C. Johnson (2008)
Salicylic acid and NIM1/NPR1-independent gene induction by incompatible Peronospora parasitica in arabidopsis.
G. Rairdan (2001)
Natural allelic variation underlying a major fitness tradeoff in Arabidopsis thaliana
M. Todesco (2010)
Isolation of in planta - induced genes of Pseudomonas viridiflava
A. Czelleng (2004)
Systemic acquired resistance.
W. E. Durrant (2004)
THE MOLECULAR BIOLOGY OF HYPERSENSITIVITY TO PLANT PATHOGENIC BACTERIA
S. Hutcheson (2001)
Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis.
H. Lu (2009)
Smut infection of perennial hosts: the genome and the transcriptome of the Brassicaceae smut fungus Thecaphora thlaspeos reveal functionally conserved and novel effectors.
Kaitlyn J Courville (2019)
Salicylic acid-driven association of LENRV and NIMIN1/NIMIN2 binding domain regions in the C-terminus of tobacco NPR1 transduces SAR signal
David Neeley (2019)
Enhanced disease resistance and hypersensitivity to BTH by introduction of an NH1/OsNPR1 paralog.
W. Bai (2011)
Apple NPR1 homologs and their alternative splicing forms may contribute to SA and disease responses
Junke Zhang (2016)
Human pathogenic bacterium Shigella infects Arabidopsis plants using type-III effectors that suppress conserved MAP kinase signaling
Sung Hee Jo (2018)
The suppressor of transgene RNA silencing encoded by Cucumber mosaic virus interferes with salicylic acid-mediated virus resistance.
L. Ji (2001)
Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases
Wan-Chi Lin (2004)
Ectopic Expression of Rice OsBIANK1, Encoding an Ankyrin Repeat-Containing Protein, in Arabidopsis Confers Enhanced Disease Resistance to Botrytis cinerea and Pseudomonas syringae
D. Li (2013)
A Novel Signaling Pathway Controlling Induced Systemic Resistance in Arabidopsis
C. Pieterse (1998)
Genes controlling expression of defense responses in Arabidopsis.
J. Glazebrook (1999)
Systemic Acquired Resistance
U. Conrath (2006)
An important role of a BAHD acyl transferase-like protein in plant innate immunity.
Z. Zheng (2009)
NPR1 enhances the DNA binding activity of the Arabidopsis bZIP transcription factor TGA7This paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.
Heather Shearer (2009)
Functional analysis of the theobroma cacao NPR1 gene in arabidopsis
Zi Shi (2010)
Salicylic Acid Signaling in Plant Innate Immunity
P. Vidhyasekaran (2015)
Induction of PR-1 Proteins and Potentiation of Pathogen Signals by Salicylic Acid Exhibit the Same Dose Response and Structural Specificity in Plant Cell Cultures
Zhixin Xie (1998)
Convergent gene loss in aquatic plants predicts new components of plant immunity and drought response
E. Baggs (2019)
The Arabidopsis NPR1/NIM1 Protein Enhances the DNA Binding Activity of a Subgroup of the TGA Family of bZIP Transcription Factors
C. Despres (2000)See more