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The Arabidopsis NIM1 Protein Shows Homology To The Mammalian Transcription Factor Inhibitor I Kappa B.

J. Ryals, K. Weymann, K. Lawton, L. Friedrich, D. Ellis, H. Steiner, J. Johnson, T. Delaney, T. Jesse, P. Vos, S. Uknes
Published 1997 · Biology, Medicine

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The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor I kappa B subclass alpha. NF-kappa B/I kappa B signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.
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