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Crystal Structure Of A Complex Of Human Chymase With Its Benzimidazole Derived Inhibitor

Y. Matsumoto, S. Kakuda, Masahiro Koizumi, Tsuyoshi Mizuno, Yumiko Muroga, T. Kawamura, M. Takimoto-Kamimura
Published 2013 · Chemistry, Medicine

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The crystal structure of human chymase complexed with a novel benzimidazole inhibitor, TJK002, was determined at 2.8 Å resolution. The present study shows that the benzimidazole ring of the inhibitor takes the stable stacking interaction with the protonated His57 in the catalytic domain of human chymase.
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