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Synthesis And Antimalarial Bioassay Of Quinine – Peptide Conjugates

S. Panda, M. A. Ibrahim, H. Küçükbay, M. J. Meyers, Francis M. Sverdrup, S. El-feky, A. R. Katritzky
Published 2013 · Medicine, Biology

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Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52–95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine.
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