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Epidermal Hyperproliferation Following The Induction Of Microabscesses By Leukotriene B4

F. Bauer, P.C.M. Kerkhof, R.M.MAASSEN‐DE Grood
Published 1986 · Medicine

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The percentage of non‐diploid epidermal cells was determined by flow cytometry following application of leukotriene B4 (LTB4) to human skin. Doses in the range 35–500 ng were shown to cause a marked increase in proliferation, the non‐diploid cells reaching a maximum between 72 and 96 h after LTB4 application. No difference was observed between the response of healthy controls and the uninvolved skin of psoriatic patients. We suggest, therefore, that the hyperproliferation is a consequence of the physical disruption of the stratum corneum accompanying the rupture of microabscesses.
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