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Topical Fish Oil In Psoriasis—a Controlled And Blind Study

S. Escobar, R. Achenbach, R. Iannantuono, V. Torem
Published 1992 · Medicine

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Omega‐3 polyunsaturated fatty acids compete with arachidonic acid as substrates for lipoperoxidases, which transform them into leukotrienes with low biological activity. As this process, in skin, may benefit psoriatic patients, a randomized controlled single blind‐study was carried out on a sample of 25 patients. In the study fish oil (FO) was compared with liquid paraffin (LP); both were topically applied and administered daily for 6 h under an occlusive dressing: over a 4‐week period. Evaluations were performed weekly assessing erythema, scaling, plaque thickness (induration) and itching.
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