Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Loratadine And Terfenadine In Perennial Allergic Rhinitis

K. Carlsen, J. Kramer, H. Fagertun, S. Larsen
Published 1993 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The efficacy of loratadine and terfenadine in perennial allergic rhinitis was evaluated in a double‐blind, selected cross‐over study consisting of two phases. During the first phase, 76 patients with perennial allergic rhinitis, 8–67 years old, were included in the study. Of these, 41 patients received loratadine 10 mg daily, and 35 patients received terfenadine 60 mg twice daily, for 2 weeks. According to symptoms and side‐effects, 32 patients were classified as responders to loratadine, and 28 patients as responders to terfenadine. All observed symptoms were significantly reduced in both treatment groups, but with no significant differences between the two groups. Side‐effects were few and mild. In patients with normal IgE, loratadine was significantly superior to terfenadine in relieving nasal secretion, whereas terfenadine was significantly superior to loratadine in relieving nasal congestion. In patients with increased IgE, patients treated with loratadine showed significantly greater reduction in sneezing than patients treated with terfenadine. A positive correlation between total IgE and reduction in overall symptoms was found for patients treated with loratadine, whereas a negative correlation was found for patients treated with terfenadine. During the second study phase, the nonresponders received the other drug for 2 weeks. All seven nonresponders to terfenadine responded to loratadine after crossing over, whereas four of nine nonresponders to loratadine responded to terfenadine. Nonresponders to one drug may respond to the other drug. Thus, more than one antihistamine drug should be tried in perennial allergic rhinitis if the first fails.
This paper references
Design and analysis of experiments. 2nd
Montgomery Dc (1984)
10.1111/j.1398-9995.1981.tb01818.x
Heterogeneity of Bronchial Asthma
K. Aas (1981)
10.1038/152431A0
The Advanced Theory of Statistics
R. Fisher (1943)
Double-blind Parallel-group Comparison of Once a Day Terfenadine and Loratadine in Seasonal Allergic Rhinitis a Multicenter Study
B. Bertrand (1990)
10.1198/tech.2006.s372
The Design and Analysis of Experiments
Margaret J. Robertson (1953)
10.1111/j.1398-9995.1992.tb05095.x
Comparison of the effects of loratadine and astemizole in the treatment of children with seasonal allergic rhinoconjunctivitis
A. Boner (1992)
10.1016/0091-6749(89)90127-9
Evaluation of the efficacy and safety of loratadine in perennial allergic rhinitis.
G. Bruttmann (1989)
10.1177/030006058901700206
Comparative Efficacy of Once Daily Loratadine versus Terfenadine in the Treatment of Allergic Rhinitis
C. Banov (1989)
10.1097/00003086-199010000-00012
A three-year retrospective study of synovectomies in children.
T. Ovregard (1990)
10.1111/j.1398-9995.1979.tb01700.x
A New Lancet for Skin Prick Testing
O. Østerballe (1979)
10.1159/000231002
Standardization of diagnostic work in allergy.
K. Aas (1973)
10.1111/j.1398-9995.1990.tb00493.x
A multicentre study of loratadine, clemastine and placebo in patients with perennial allergic rhinitis
L. Frøulund (1990)
H1 antihistamines: perspective on the use of the conventional and new agents.
Drouin Ma (1985)
Heterogeneity of bronchial asthnia
K. AAS (1981)
As - sessing soft data in clinical trials
S LARSEN (1991)
Evaluation of the efficacy and safety of loratadine in perennial allergic rhitnitis
D BRUTTMAN G . CHARPIN (1989)



This paper is referenced by
Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among triclosan dentifrice users.
T. He (2013)
10.1016/j.otohns.2007.02.031
Keys to successful management of patients with allergic rhinitis: Focus on patient confidence, compliance, and satisfaction
B. Marple (2007)
10.3111/13696990701640653
Impact of formulary management and step therapy for non-sedating antihistamines on prescription drug utilisation and costs
S. Sun (2007)
10.1007/BF03259495
H1-Receptor Antagonists in the Management of Allergic Rhinitis
Dr Kalliopi Kontou-Fili (2012)
10.2147/BCTT.S71781
BP-C1 in the treatment of patients with stage IV breast cancer: a randomized, double-blind, placebo-controlled multicenter study and an additional open-label treatment phase
S. Larsén (2014)
10.2165/00003495-200161110-00004
Intranasal Corticosteroids for Allergic Rhinitis
L. Nielsen (2012)
10.1111/j.1399-3038.1996.tb00103.x
Fluticasone propionate aqueous nasal spray: a well‐tolerated and effective treatment for children with perennial rhinitis
D. H. Richards (1996)
10.1067/MAI.2001.118891
Allergic rhinitis and its impact on asthma.
J. Bousquet (2001)
10.2147/BCTT.S174298
Efficacy and tolerability of BP-C1 in metastatic breast cancer: a Phase II, randomized, double-blind, and placebo-controlled Thai multi-center study
Kritiya Butthongkomvong (2019)
10.1016/S0335-7457(00)80027-1
What are the perspectives in the future for H1-antihistamines ?
J. Bousquet (2000)
10.1002/j.1875-9114.1996.tb03008.x
Treating Allergic Rhinitis with Second‐Generation Antihistamines
C. Nightingale (1996)
10.1007/978-4-431-99362-9_3
Antihistamines in Rhinitis and Asthma
T. A. Popov (2009)
10.1200/JCO.2015.33.15_SUPPL.E12086
BP-C1 in treatment of patients with stage IV breast cancer: A randomized, double-blind, placebo-controlled multicenter study and additional open-label treatment phase.
S. Larsén (2015)
10.1007/BF03259282
Pharmacotherapy of Perennial and Seasonal Allergic Rhinitis
Dr Helen F. Krause (2012)
Estudio abierto, aleatorio, controlado, para evaluar la seguridad y eficacia clínica de epinastina 10 mg jarabe versus loratadina 10 mg jarabe, en pacientes de 6 a 12 años de edad con diagnóstico de rinitis alérgica
J. Monge (2000)
10.1016/j.jaci.2008.06.003
The diagnosis and management of rhinitis: an updated practice parameter.
D. Wallace (2008)
10.2147/DDDT.S80451
Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance
Steen Lindkær-Jensen (2015)
10.1111/J.1439-0442.2004.00661.X
Comparison of homeopathy, placebo and antibiotic treatment of clinical mastitis in dairy cows - methodological issues and results from a randomized-clinical trial.
L. Hektoen (2004)
Efficacy and tolerability of BPC 1 in metastatic breast cancer : a Phase II , randomized , double-blind , and placebo-controlled Thai multi-center study
Kritiya Butthongkomvong (2019)
10.2500/aap.2012.33.3535
Chapter 5: Allergic rhinitis.
Ashraf Uzzaman (2012)
Breast Cancer: Targets and Therapy Dovepress
()
10.1186/1751-0147-56-13
ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses
I. R. Hellings (2014)
10.1034/j.1399-3038.1999.00028.x
Perinatal risk factors for recurrent wheeze in early life
K. L. Lødrup Carlsen (1999)
10.1111/j.1398-9995.1998.tb03775.x
Effect of continuous allergen challenge on clinical symptoms and mediator release in dust‐mite‐allergic patients
F. Horak (1998)
10.1046/j.1365-2222.2003.01690.x
Montelukast as an adjuvant to mainstay therapies in patients with seasonal allergic rhinitis
B. Topuz (2003)
10.1111/jsap.12159
Purring in cats during auscultation: how common is it, and can we stop it?
C. Little (2014)
10.1177/0194599814561600
Clinical Practice Guideline
M. Seidman (2015)
Antigingivitis efficacy of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice in subjects previously nonresponsive to a triclosan/copolymer dentifrice.
L. Archila (2005)
Semantic Scholar Logo Some data provided by SemanticScholar