Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Expression Of Isoferritins In Peripheral Blood Lymphocytes: Effect Of Phytohaemagglutinin And Iron

K. Pattanapanyasat
Published 1989 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
This study shows that incubation of lymphocytes in phytohaemagglutinin medium together with iron supplementation leads to an increase of ferritin synthesis concomitant with increased intracellular ferritin concentration especially of heart‐type ferritin. Increasing levels of iron do not increase heart‐type ferritin concentration further; in contrast, spleen‐type ferritin is gradually increased with increasing iron levels. The preferential increase in spleen‐type ferritin on growth in iron‐enriched medium may be explained by two distinct roles in the metabolism of these two isoferritins. Heart‐type isoferritin appears to be involved in more active iron metabolism in lymphocytes whilst the spleen‐type isoferritin may function as an intracellular depot of excess iron that is not immediately utilised for metabolic activity.
This paper references
10.1038/bjc.1988.41
Ferritin-bearing T-lymphocytes and serum ferritin in patients with breast cancer.
K. Pattanapanyasat (1988)
10.1111/j.1365-2141.1975.tb01857.x
Ferritin Synthesis in Lymphocytes, Polymorphs and Monocytes
M. Summers (1975)
10.1056/NEJM197401242900402
Impaired lymphocyte function in untreated Hodgkin's disease.
R. Levy (1974)
Thymus-derived lymphocyte (T-cell) depletion in Hodgkin's disease.
B. Ramot (1973)
10.1111/j.1365-2141.1985.tb07331.x
Differential effect of isolated placental isoferritins on in vitro T‐lymphocyte function
Y. Matzner (1985)
Ferntin-bearing T-lymphocyte and serum ferritin in patients with breast cancer
K Pattanapanyasat (1988)
Uptake and release of transferrin and iron by mitogen-stimulated huma lymphocytes
A Bomford (1983)
10.1111/j.1365-2141.1988.tb02416.x
Effect of phytohaemagglutinin on the synthesis and secretion of ferritin in peripheral blood lymphocytes
K. Pattanapanyasat (1988)
10.1007/BF02237395
Serum ferritin
J. Scholefield (1979)
10.1111/j.1365-2141.1983.tb01227.x
Uptake and release of transferrin and iron by mitogen‐stimulated human lymphocytes
A. Bomford (1983)
10.1111/j.1365-2141.1986.tb02905.x
Ferritins in malignant and non‐malignant lymphoid cells
P. Vezzoni (1986)
The response of intracellular and surface ferritin following T-cell stimulation in vitro
K Pattanapanyasat (1987)
10.1016/0009-8981(78)90104-3
An immunoradiometric assay for the acidic ferritin of human heart: application to human tissues, cells and serum.
B. Jones (1978)
10.1126/SCIENCE.6967622
Ferritin synthesis by human T lymphocytes.
M. Dörner (1980)
Imparied lymphocyte function in untreated Hodgkin's disease
R Levy (1974)
Ferritin , a ng substance in the leucocyte migration inhibition test in patients with malignant lymphoma
BW Hancock (1979)
Urca 1. Ferritin-bearing lymphocytes and T-cell levels in peripheral blood of patients with breast cancer
C Moroz (1977)
Iron overload in Chang cell cultures: biochemical and morphological studies.
A. Jacobs (1978)
10.1111/j.1365-2141.1983.tb02013.x
Erythrocyte ferritin in normal subjects and patients with abnormal iron metabolism
S. Peters (1983)
10.1111/j.1365-2141.1984.tb01269.x
Accumulation and release of isoferritins during incubation in vitro of human peripheral blood mononuclear cells
M. Worwood (1984)
10.1136/jcp.24.5.472
The preparation of 59Fe-labelled transferrin for ferrokinetic studies
I. Cavill (1971)
10.1111/j.1365-2141.1986.tb02960.x
Intracellular forms of iron during transferrin iron uptake by mitogen‐stimulated human lymphocytes
A. Bomford (1986)
Human isoferritins in normal and disease states.
J. Drysdale (1977)
10.1182/BLOOD.V68.6.1257.1257
The influence of purified recombinant human heavy-subunit and light-subunit ferritins on colony formation in vitro by granulocyte-macrophage and erythroid progenitor cells.
H. Broxmeyer (1986)
Isoferritin in normal leucocytes
BM Jones (1983)
Human isofer - ritins in normal and disease states
JW Drysdale (1977)
10.1042/BJ1930087
Changes in the characteristics and distribution of ferritin in iron-loaded cell cultures.
T. Hoy (1981)
10.1042/CS0730605
The response of intracellular and surface ferritin after T-cell stimulation in vitro.
K. Pattanapanyasat (1987)
Ferritin: an interim review.
A. Jacobs (1985)
10.1016/0005-2787(80)90023-4
Evidence for post-translational changes in rat liver ferritin.
A. Treffry (1980)
10.1002/1097-0142(19840701)54:1<84::AID-CNCR2820540118>3.0.CO;2-T
Ferritin‐bearing lymphocytes in the diagnosis of breast cancer
C. Moroz (1984)
10.1111/j.1365-2141.1983.tb01225.x
Isoferritins in normal leucocytes
B. Jones (1983)
10.1111/j.1600-0609.1989.tb01470.x
Ferritin synthesis in peripheral blood lymphocytes following in vitro stimulation*
K. Pattanapanyasat (1989)
Iron in Biochemistry and Medicine, 11
A Jacobs (1980)
10.1111/j.1365-2141.1974.tb06636.x
Ferritin in Normal Erythrocytes, Lymphocytes, Polymorphs, and Monocytes
M. Summers (1974)
10.1111/j.1365-2141.1979.tb03745.x
Ferritin, a Sensitizing Substance in the Leucocyte Migration Inhibition Test in Patients with Malignant Lymphoma
B. Hancock (1979)
10.1016/S0140-6736(61)91724-X
SERUM "α-HYDROXYBUTYRIC DEHYDROGENASE" IN MYOCARDIAL INFARCTION AND IN LIVER DISEASE
B. A. Elliott (1961)
10.1016/s0021-9258(19)70770-4
Differential turnover of rat liver isoferritins.
Y. Kohgo (1980)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar