Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Mast Cell Tryptases And Chymases In Inflammation And Host Defense

G. Caughey
Published 2007 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Summary:  Tryptases and chymases are the major proteins stored and secreted by mast cells. The types, amounts, and properties of these serine peptidases vary by mast cell subtype, tissue, and mammal of origin. Membrane‐anchored γ‐tryptases are tryptic, prostasin‐like, type I peptidases that remain membrane attached on release and act locally. Soluble tryptases, including their close relatives, mastins, form inhibitor‐resistant oligomers that act more remotely. Befitting their greater destructive potential, chymases are quickly inhibited after release, although some gain protection by associating with proteoglycans. Most chymase‐like enzymes, including mast cell cathepsin G, hydrolyze chymotryptic substrates, an uncommon capability in the proteome. Some rodent chymases, however, have mutations resulting in elastolytic activity. Secreted tryptases and chymases promote inflammation, matrix destruction, and tissue remodeling by several mechanisms, including destroying procoagulant, matrix, growth, and differentiation factors and activating proteinase‐activated receptors, urokinase, metalloproteinases, and angiotensin. They also modulate immune responses by hydrolyzing chemokines and cytokines. At least one chymase protects mice from intestinal worms. Tryptases and chymases can also oppose inflammation by inactivating allergens and neuropeptides causing inflammation and bronchoconstriction. Thus, like mast cells themselves, mast cell serine peptidases play multiple roles in host defense, and any accounting of benefit versus harm is necessarily context specific.
This paper references
10.1084/JEM.192.3.455
Mast Cells Can Amplify Airway Reactivity and Features of Chronic Inflammation in an Asthma Model in Mice
C. Williams (2000)
10.1073/PNAS.96.15.8348
Potent selective nonpeptidic inhibitors of human lung tryptase.
L. E. Burgess (1999)
10.1046/j.1365-2222.1999.00580.x
Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi
Berger (1999)
10.1084/JEM.187.12.2045
Dermal Mast Cells Determine Susceptibility to Ultraviolet B–induced Systemic Suppression of Contact Hypersensitivity Responses in Mice
P. Hart (1998)
10.1074/JBC.M410396200
A Key Role for Mast Cell Chymase in the Activation of Pro-matrix Metalloprotease-9 and Pro-matrix Metalloprotease-2*
E. Tchougounova (2005)
10.1016/S0092-8674(00)00139-2
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
L. Coussens (2000)
10.1111/j.1600-0625.1999.tb00383.x
Proteinase‐activated receptor‐2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase
M. Steinhoff (1999)
10.1038/sj.bjp.0705121
A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium
T. Sendo (2003)
10.1007/s00251-006-0126-1
Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution
Maike Gallwitz (2006)
10.1038/35422
Design of potent selective zinc-mediated serine protease inhibitors
B. Katz (1998)
10.1172/JCI119658
Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.
C. Corvera (1997)
10.4049/jimmunol.174.11.7285
Mast Cell Protease 5 Mediates Ischemia-Reperfusion Injury of Mouse Skeletal Muscle1
J. P. Abonia (2005)
10.1165/AJRCMB.24.2.4165
Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth-muscle cells: importance of proteolytic events, time course, and role in mediating mitogenesis.
James K. Brown (2001)
10.1016/J.YEXCR.2005.12.033
Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling.
M. Leskinen (2006)
10.1172/JCI118583
Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.
K. Fang (1996)
Characterization of human g-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families
GH Caughey (2000)
10.4049/jimmunol.176.6.3788
Mast Cell β-Tryptase Selectively Cleaves Eotaxin and RANTES and Abrogates Their Eosinophil Chemotactic Activities1
L. Pang (2006)
10.1016/J.PEP.2006.04.018
Expression and characterization of recombinant ?-tryptase
J. Yuan (2006)
10.1111/J.0906-6705.2004.0212CO.X
Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.
M. Steinhoff (2003)
10.1016/j.rmed.2007.01.004
Mast cell infiltration of airway smooth muscle in asthma.
P. Bradding (2007)
10.1021/BI00473A024
Dog mast cell chymase: molecular cloning and characterization.
G. Caughey (1990)
10.1111/j.1610-0387.2005.05706.x
Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus
S. Dugas-Breit (2005)
10.4049/jimmunol.168.1.290
Mast Cell α-Chymase Reduces IgE Recognition of Birch Pollen Profilin by Cleaving Antibody-Binding Epitopes1
Matthew B Mellon (2002)
10.1021/BI972119Z
Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption.
V. A. Thomas (1998)
Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6.
C. Huang (1998)
Delayed Expulsion of the Nematode Trichinella spiralis in Mice Lacking the Mucosal Mast Cell – specific Granule Chymase
P. Knight (2000)
10.1074/jbc.M301512200
Extended Substrate Specificity of Rat Mast Cell Protease 5, a Rodent α-Chymase with Elastase-like Primary Specificity*
U. Karlson (2003)
10.1056/NEJM199307083290204
Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin.
T. Ahmed (1993)
10.1183/09031936.97.10122868
Incremental threshold loading: a standard protocol and establishment of a reference range in naive normal subjects.
P. Johnson (1997)
10.1016/S0167-4838(02)00224-8
Lys40 but not Arg143 influences selectivity of angiotensin conversion by human α-chymase
D. Muilenburg (2002)
10.1016/J.EJPHAR.2005.11.021
Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice.
Haruna Ui (2006)
10.1126/SCIENCE.1128877
Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms
M. Metz (2006)
10.1172/JCI20805
Involvement of chymase-mediated angiotensin II generation in blood pressure regulation.
Ming Li (2004)
10.1006/BBRC.2000.3292
A novel 31-amino-acid-length endothelin, ET-1(1-31), can act as a biologically active peptide for vascular smooth muscle cells.
N. Nagata (2000)
10.1046/j.1365-2036.2002.01194.x
Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open‐label pilot study
W. Tremaine (2002)
Cloning and expression of the dog mast cell α-chymase gene
GH Caughey (1997)
10.1016/S1097-2765(03)00308-3
A despecialization step underlying evolution of a family of serine proteases.
M. A. Wouters (2003)
Inactivation of human high molecular weight kininogen by human mast cell tryptase.
M. Maier (1983)
Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse.
N. Ghildyal (1994)
Expression and characterization of recombinant g-tryptase
J Yuan (2006)
10.1002/1521-4141(200106)31:6<1736::AID-IMMU1736>3.0.CO;2-T
Hapten‐specific tolerance induced by acute, low‐dose ultraviolet B radiation of skin requires mast cell degranulation
P. Alard (2001)
10.1172/JCI114744
Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs.
I. Rubinstein (1990)
10.1016/0003-9861(87)90377-8
Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence.
G. Caughey (1987)
10.1172/JCI114492
Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.
C. Sommerhoff (1990)
10.1183/09031936.97.10010038
Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus.
P. Johnson (1997)
contributes to skin carcinogenesis
BL Gruber (2000)
10.1097/01.MCA.0000224420.67304.4D
Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion
M. Mäyränpää (2006)
10.1038/nature03085
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
M. Maurer (2004)
10.1172/JCI115330
Mast cell tryptase is a mitogen for cultured fibroblasts.
S. J. Ruoss (1991)
10.1016/J.JACI.2006.02.047
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
Chih-Lung Chen (2006)
10.1074/JBC.M405576200
Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II*
A. Lundequist (2004)
10.1021/BI992182J
A novel approach to serine protease inhibition: kinetic characterization of inhibitors whose potencies and selectivities are dramatically enhanced by Zinc(II).
J. Janc (2000)
10.1172/JCI19062
Mast cell dipeptidyl peptidase I mediates survival from sepsis.
J. Mallen-St. Clair (2004)
10.1291/HYPRES.26.759
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
T. Koga (2003)
10.4049/jimmunol.164.12.6566
Characterization of Human γ-Tryptases, Novel Members of the Chromosome 16p Mast Cell Tryptase and Prostasin Gene Families1
G. Caughey (2000)
10.1038/381077A0
Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α
Ravi Malaviya (1996)
10.4049/jimmunol.171.3.1493
Human Mast Cell β-Tryptase Is a Gelatinase 1
I. Fajardo (2003)
10.1046/j.1365-2222.2002.01416.x
Genetic deficiency of human mast cell a‐tryptase
D. Soto (2002)
10.1152/JAPPL.1995.79.6.1966
Role of tryptase in immediate cutaneous responses in allergic sheep.
J. Molinari (1995)
10.1016/0006-2952(88)90008-1
Identification of human lung mast cell kininogenase as tryptase and relevance of tryptase kininogenase activity.
D. Proud (1988)
10.1038/335073a0
Substance P regulates the vasodilator activity of calcitonin gene-related peptide
S. Brain (1988)
10.1097/00004872-200210000-00025
Transgenic study of the function of chymase in heart remodeling
L. Chen (2002)
10.1172/JCI113855
Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs.
K. Sekizawa (1989)
10.1074/jbc.275.1.351
Formation of Enzymatically Active, Homotypic, and Heterotypic Tetramers of Mouse Mast Cell Tryptases
C. Huang (2000)
10.1007/978-3-642-68211-7_14
Mast cell proteases.
R. Woodbury (1981)
10.1152/AJPLUNG.1992.262.5.L528
Human tryptase as a potent, cell-specific mitogen: role of signaling pathways in synergistic responses.
T. Hartmann (1992)
10.1002/path.1690
Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts
P. Somasundaram (2005)
10.4049/jimmunol.166.4.2783
Mast Cell Tissue Inhibitor of Metalloproteinase-1 Is Cleaved and Inactivated Extracellularly by α-Chymase1
B. Frank (2001)
10.4049/jimmunol.176.7.4141
Mast Cell-Dependent Down-Regulation of Antigen-Specific Immune Responses by Mosquito Bites1
Nadya Depinay (2006)
Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression.
J. Cairns (1996)
10.1016/S0960-894X(02)00063-X
Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors.
N. Schaschke (2002)
Induction of vascular permeability enhancement by human tryptase: dependence on activation of prekallikrein and direct release of bradykinin from kininogens.
T. Imamura (1996)
10.1177/40.6.1588024
Distribution of chymase-containing mast cells in human bronchi.
R. Matin (1992)
10.1067/MAI.2001.115631
Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma.
M. T. Krishna (2001)
10.1165/RCMB.F258
Building a better heparin.
G. Caughey (2003)
10.1097/00001573-200207000-00009
Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases.
L. Dell'Italia (2002)
10.1161/01.ATV.0000149753.74793.88
Proteolysis of pericellular matrix: a process linking inflammation to plaque destabilization and rupture.
K. Lindstedt (2004)
Systemic release of mucosal mast-cell protease in primed rats challenged with Nippostrongylus brasiliensis.
H. Miller (1983)
10.1067/MAI.2001.114989
The other side of the coin: the protective role of the TH2 cytokines.
F. Finkelman (2001)
10.4049/jimmunol.168.4.1992
Tryptase Inhibition Blocks Airway Inflammation in a Mouse Asthma Model1
S. Oh (2002)
Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor.
T. Selwood (2003)
10.1172/JCI119290
Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts.
J. Cairns (1997)
10.1016/S0167-4838(00)00076-5
Angiotensin II generation by mast cell α- and β-chymases
G. Caughey (2000)
Mast cell and neutrophil expression of dog mast cell protease-3. A novel tryptase-related serine protease.
M. J. Yezzi (1994)
Inhibition of allergeninduced pulmonary responses by the selective tryptase inhibitor 1
C D Wright
10.1126/SCIENCE.2911721
Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II.
G. MacQueen (1989)
10.1084/JEM.192.12.1849
Delayed Expulsion of the Nematode Trichinella spiralisIn Mice Lacking the Mucosal Mast Cell–Specific Granule Chymase, Mouse Mast Cell Protease-1
P. Knight (2000)
10.1152/AJPCELL.00637.2005
Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.
G. M. Verghese (2006)
10.1152/AJPLUNG.2002.282.2.L197
Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions.
James K. Brown (2002)
10.1084/jem.20030671
The Chymase, Mouse Mast Cell Protease 4, Constitutes the Major Chymotrypsin-like Activity in Peritoneum and Ear Tissue. A Role for Mouse Mast Cell Protease 4 in Thrombin Regulation and Fibronectin Turnover
E. Tchougounova (2003)
10.1016/J.ABB.2004.12.025
Mastin is a gelatinolytic mast cell peptidase resembling a mini-proteasome.
W. Raymond (2005)
10.1074/jbc.274.43.30784
Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension*
G. W. Wong (1999)
A novel 31amino-acid-length endothelin, ET-1(1-31), can act as a biologically active peptide for vascular smooth muscle cells
N Nagata (2000)
Mast cell tryptase and chymase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret.
G. Franconi (1989)
Mast cell chymase. A potent secretagogue for airway gland serous cells.
C. Sommerhoff (1989)
10.1038/72247
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
M. Steinhoff (2000)
10.1016/S0161-5890(02)00087-1
New developments in the genetics and activation of mast cell proteases.
G. Caughey (2002)
Human tryptase fibrinogenolysis is optimal at acidic pH and generates anticoagulant fragments in the presence of the anti-tryptase monoclonal antibody B12.
S. Ren (1997)
10.1074/jbc.272.50.31885
The Tryptase, Mouse Mast Cell Protease 7, Exhibits Anticoagulant Activity in Vivo and in Vitro Due to Its Ability to Degrade Fibrinogen in the Presence of the Diverse Array of Protease Inhibitors in Plasma*
C. Huang (1997)
10.1007/s00251-006-0123-4
Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution
Maike Gallwitz (2006)
10.1172/JCI114344
Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation.
B. Gruber (1989)
10.1016/J.JACI.2004.12.771
Cytokine production by skin-derived mast cells: endogenous proteases are responsible for degradation of cytokines.
W. Zhao (2005)
10.1164/AJRCCM.152.6.8520778
Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.
J. Clark (1995)
10.1016/S0960-894X(99)00594-6
Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors.
S. Ono (1999)
10.1111/J.1472-9725.2004.00041.X
Genetic insights into mast cell chymase and tryptase function
G. Caughey (2004)
10.1097/00041433-200410000-00011
Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture
K. Lindstedt (2004)
10.1254/JPHS.92.420
Nafamostat mesilate is an extremely potent inhibitor of human tryptase.
S. Mori (2003)
10.1172/JCI25702
Mast cells can promote the development of multiple features of chronic asthma in mice.
M. Yu (2006)
10.1073/pnas.131147598
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice
H. Ju (2001)
Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases.
G. Caughey (1993)
10.1006/GENO.1993.1115
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
G. Caughey (1993)
10.1021/BI00436A004
Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation.
P. Vanderslice (1989)
10.4049/jimmunol.171.7.3808
Activation of Mast Cells Is Essential for Development of House Dust Mite Dermatophagoides farinae-Induced Allergic Airway Inflammation in Mice1
C. Yu (2003)
10.1074/jbc.M304087200
Albumin Is a Substrate of Human Chymase
W. Raymond (2003)
10.1101/GAD.13.11.1382
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.
L. Coussens (1999)
10.1074/JBC.M102356200
Evaluation of the Substrate Specificity of Human Mast Cell Tryptase βI and Demonstration of Its Importance in Bacterial Infections of the Lung*
C. Huang (2001)
Inhibition of allergeninduced pulmonary responses by the selective tryptase inhibitor
CD Wright (1996)
10.1165/AJRCMB/3.1.27
Degradation of airway neuropeptides by human lung tryptase.
E. Tam (1990)
10.1016/0167-4838(88)90109-4
Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases.
G. Caughey (1988)
10.1172/JCI119458
Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor.
R. J. Blair (1997)
10.1074/jbc.M209353200
Structure and Activity of Human Pancreasin, a Novel Tryptic Serine Peptidase Expressed Primarily by the Pancreas*
V. Bhagwandin (2003)
10.1164/AJRCCM.154.3.8810600
Inhaled tryptase causes bronchoconstriction in sheep via histamine release.
J. Molinari (1996)
10.1165/AJRCMB.13.2.7626290
Tryptase, the dominant secretory granular protein in human mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells.
James K. Brown (1995)
10.1111/j.1365-2222.2006.02474.x
Effects of a reversible β‐tryptase and trypsin inhibitor (RWJ‐58643) on nasal allergic responses
E. Erin (2006)
10.1016/s0021-9258(17)38401-6
Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.
L. Schwartz (1986)
10.1056/NEJMOA012705
Mast-cell infiltration of airway smooth muscle in asthma.
C. Brightling (2002)
10.1101/GR.1946304
A genomic analysis of rat proteases and protease inhibitors.
X. S. Puente (2004)
10.1016/J.PHARMTHERA.2006.05.008
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.
M. Miyazaki (2006)
Mast cell b-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities
L Pang (2006)
10.1074/jbc.M205868200
Biochemical and Functional Characterization of Human Transmembrane Tryptase (TMT)/Tryptase γ
G. W. Wong (2002)
10.1074/JBC.270.22.13164
Purification and Characterization of Dog Mast Cell Protease-3, an Oligomeric Relative of Tryptases (*)
W. Raymond (1995)
10.1073/PNAS.87.10.3811
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
P. Vanderslice (1990)
10.1007/BF00917506
Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats
N. Hirasawa (2004)
10.1165/AJRCMB/2.5.449
Protease inhibitors potentiate smooth muscle relaxation induced by vasoactive intestinal peptide in isolated human bronchi.
E. Tam (1990)
10.1161/01.ATV.18.11.1707
Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques.
J. Johnson (1998)
10.1046/J.1432-1033.2002.03316.X
Rodent α‐chymases are elastase‐like proteases
Y. Kunori (2002)
10.1016/S0006-2952(99)00304-4
Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]-phenoxy]-pen tane (AMG-126737).
C. D. Wright (1999)
10.1074/jbc.273.50.33224
A Novel Mechanism for Bradykinin Production at Inflammatory Sites
A. Kozik (1998)
10.1038/35096564
Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors
M. Jutel (2001)
Cloning and expression of the dog mast cell alpha-chymase gene.
G. Caughey (1997)
Purification and characterization of dog mastocytoma chymase. Identification of an octapeptide conserved in chymotryptic leukocyte proteases
GH Caughey (1988)
10.1084/JEM.182.6.1871
Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum
C. Scudamore (1995)
10.1164/AJRCCM/137.5.1002
Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma.
S. Wenzel (1988)
10.1016/J.VETIMM.2006.09.001
A functional comparison of canine and murine bone marrow derived cultured mast cells.
T. Lin (2006)
10.1074/jbc.274.6.3355
Characterization of Genes Encoding Known and Novel Human Mast Cell Tryptases on Chromosome 16p13.3*
M. Pallaoro (1999)
10.1016/J.JACI.2006.02.026
Tryptase genetics and anaphylaxis.
G. Caughey (2006)
Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis.
B. Gruber (1997)
10.1074/jbc.272.41.25628
Dog Mast Cell α-Chymase Activates Progelatinase B by Cleaving the Phe88-Gln89 and Phe91-Glu92 Bonds of the Catalytic Domain*
K. Fang (1997)
10.1164/RCCM.200507-1034OC
Mast cells protect mice from Mycoplasma pneumonia.
X. Xu (2006)
Mast cell chymase-like protease(s) modulates Escherichia coli lipopolysaccharide-induced vasomotor dysfunction in skeletal muscle in vivo.
H. Suzuki (1998)
Cloning and expression of the dog mast cell a-chymase gene
GH Caughey (1997)
10.1038/nature05010
Mast cells are essential intermediaries in regulatory T-cell tolerance
L. Lu (2006)
10.1016/s0021-9258(18)34171-1
Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases.
C. Reilly (1982)



This paper is referenced by
10.1590/abd1806-4841.20165077
Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face*
Águida Cristina Gomes Henriques (2016)
10.1111/jop.12400
Interaction of stromal and microvascular components in keratocystic odontogenic tumors.
Ernesto Santos Sousa-Neto (2016)
10.1016/j.jaci.2013.02.011
Human mast cells arise from a common circulating progenitor.
Katariina Maaninka (2013)
10.1111/exd.12924
Phenotypic variability in human skin mast cells
M. Babina (2016)
10.1007/978-3-0348-0157-7_8
Proteases/Antiproteases in Inflammatory Bowel Diseases
Jean-Paul Motta (2011)
10.1016/j.chroma.2009.01.063
Study of the human plasma proteome of rheumatoid arthritis.
Xiaoyang Zheng (2009)
Chlorinated lipid induce inflammatory responses in the microcirculation
Hong Yu (2017)
10.1007/978-1-4614-5930-9_12
Role of Chymase in Matrix and Myocardial Remodeling Due to Mitral Regurgitation: Implications for Therapy
S. Melby (2013)
10.1155/2012/358184
MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models
Jianwei Lv (2012)
10.1007/s10753-011-9422-5
Mast-Cell-Releasing Tryptase Triggers Acute Lung Injury Induced by Small Intestinal Ischemia–Reperfusion by Activating PAR-2 in Rats
X. Gan (2011)
10.1016/j.exer.2013.05.015
Involvement of chymase in allergic conjunctivitis of guinea pigs.
T. Nabe (2013)
10.1096/fj.12-223867
Histamine production by human neutrophils
Lorena Alcañiz (2013)
10.5301/RU.2010.5905
[Perception of chronic pelvic pain in women: predictors and clinical implications].
A. Graziottin (2008)
Measurement of mast cell and basophil activation in vitro as means for investigation of drug hypersensitivity
D. Ludwig (2015)
10.3389/fimmu.2020.00163
The Role of Mast Cells in Bone Metabolism and Bone Disorders
D. Ragipoglu (2020)
10.1016/B978-0-12-385504-6.00001-4
Membrane-Anchored Serine Proteases in Health and Disease
T. Antalis (2011)
10.1007/978-1-60327-003-8_1
Delineating protease functions during cancer development.
N. I. Affara (2009)
10.3390/ijerph13101008
L-Asparaginase Isolated from Phaseolus vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo
S. A. Mohamed (2016)
10.4049/jimmunol.1302520
Does β-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of β-Hexosaminidase in Mast Cell Granules
N. Fukuishi (2014)
10.5603/FHC.2011.0068
Participation of mast cells in chronic otitis media.
A. Pajor (2011)
10.1016/j.semcdb.2017.02.002
Mast cell secretome: Soluble and vesicular components.
K. Vukman (2017)
10.1016/bs.ai.2014.09.002
Mast cells' integrated actions with eosinophils and fibroblasts in allergic inflammation: implications for therapy.
N. Landolina (2015)
10.1016/B978-0-12-374001-4.00009-2
Mast Cells and Basophils
G. Caughey (2009)
10.1016/j.jaci.2008.01.019
Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution.
N. Trivedi (2008)
Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ER and glucocorticoid receptor
L. Salamonsen (2017)
10.1007/978-0-387-93874-5_7
Proteinase Optical Imaging Tools for Cancer Detection and Response to Therapy
J. Mcintyre (2010)
10.1007/s13277-011-0274-2
Distribution of mast cells in benign odontogenic tumors
Francisco Assis Caldas Pereira (2011)
10.2741/4140
Role of mast cells in gynecological neoplasms.
L. Jiang (2013)
10.1016/j.jnutbio.2015.11.015
Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10(-/-) colitis.
Y. Hagenlocher (2016)
10.1902/jop.2012.120066
Mast cell degranulation in human periodontitis.
S. Huang (2013)
10.1016/S0065-7743(08)00011-0
Protease Inhibitors for the Potential Treatment of Chronic Obstructive Pulmonary Disease and Asthma
W. Liu (2008)
10.1111/mec.15241
Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent
Jenni Kesäniemi (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar