Online citations, reference lists, and bibliographies.
← Back to Search

Improvement Of Ocular Penetration Of Amikacin Sulphate By Association To Poly(butylcyanoacrylate) Nanoparticles

C. Losa, P. Calvo, E. Castro, J. L. Vila-jato, M. J. Alonso
Published 1991 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Abstract— The main objective of this paper was to investigate the ability of polycyanoacrylate nanoparticles to improve the corneal penetration of hydrophilic drugs. Three different nanoparticle formulations were prepared by changing the nature of the stabilizer agent (Dextran 70000, Synperonic F 68 and sodium lauryl sulphate). The significant influence of the stabilizer type on the particle size, electrophoretic mobility and on the drug loading efficiency was proved. Moreover, the ocular disposition of amikacin was affected by its association to nanoparticles, displaying the most interesting results when Dextran 70000 was employed for preparation of nanoparticles. The increase of the amikacin concentration in cornea and aqueous humour was statistically significant for this nanoparticle formulation with respect to the other formulations and the control solution. The in‐vitro release profiles obtained using a dialysis system were similar for all the nanoparticle formulations and for the control solution, indicating that drug molecules are desorbed from the nanoparticles quickly enough to maintain the equilibrium concentration in the dialysis system.
This paper references
Topical tobramycin therapy of experimental Pseudomonas keratitis: an evaluation of some factors that potentially enhance efficacy.
S. D. Davis (1978)
A γ-scintigraphic evaluation of microparticulate ophthalmic delivery systems: liposomes and nanoparticles
P. Fitzgerald (1987)
Review: topical oculardelivery: recent developments and future challenges
V.H.L. Lee (1986)
Intraocular penetration of amikacin. Iris binding and bioavailability.
R. Eiferman (1982)
Amikacin sulphate. In: Florey, K. (ed.) Analytical Profiles of Drug Substances
P. M. Monteleone (1983)
Topical ocular drug delivery: recent developments and future challenges.
V. Lee (1986)
Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticle preparations
L. Marchal-Heussler (1990)
Enhancement of the myotic response of rabbits with pilocarpine-loaded polybutylcyanoacrylate nanoparticles
T. Harmia (1986)
Ocular disposition of poly-hexyl-2-cyano[3-14C]acrylate nanoparticles in the albino rabbit
R. Wood (1985)
Approaches to improve the association of amikacin sulphate to poly(alkylcyanoacrylate) nanoparticles
M. Alonso (1991)
Topical vs systemic gentamicin penetration into the human cornea and aqueous humor.
M. Insler (1987)
Amikacin sulphate
P. M. Monteleone (1983)
Colloidal carriers for drug targeting + harge reduction by coating with polymers
R. H. Miiller (1986)
In vitro adsorption studies of cimetidine.
F. Ganjian (1980)
Colloidal carriers for drug targeting+harge reduction by coating with polymers. Abstr
R. H. Miiller (1986)
Optimization of pilocarpine loading onto nanoparticles by sorption procedures
T. Harmia (1986)
Electrophoresis of particles in suspensions
A. M. James (1979)
Pluronic polyoles
Smolka (1967)
Adsorption Isotherm for Doxorubicin on Erythrocyte-Membrane
A. Al-Achi (1990)
Effect of dioctyl sodium sulfosuccinate and poloxamer 188 on dissolution and intestinal absorption of sulfadiazine and sulfisoxazole in rats.
R. K. Reddy (1976)

This paper is referenced by
Drug Delivery Systems
D. Paolino (2006)
Drug delivery to eye: Special reference to nanoparticles
Swarnali Das (2010)
Design of New Formulations for Topical Ocular Administration: Polymeric Nanocapsules Containing Metipranolol
C. Losa (2004)
Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen.
R. Pignatello (2002)
Brimonidine formulation in polyacrylic acid nanoparticles for ophthalmic delivery
T. K. De (2003)
Mucoadhesive properties of chitosan-coated ophthalmic lipid emulsion containing indomethacin in tear fluid.
M. Yamaguchi (2009)
Charged nanoparticles delivery to the eye using hydrogel iontophoresis.
E. Eljarrat-Binstock (2008)
Mucoadhesive Polymers for Enhancing Retention in Ocular Drug Delivery: A Critical Review
Anubha Khare (2014)
Chitosan nanoparticles as a potential drug delivery system for the ocular surface: toxicity, uptake mechanism and in vivo tolerance.
Amalia Enríquez de Salamanca (2006)
Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers
P. Calvo (1997)
Nanotherapies for the treatment of ocular diseases.
S. Reimondez-Troitiño (2015)
Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules, and nanoemulsions, as ocular drug carriers.
P. Calvo (1996)
Nanoparticle-based topical ophthalmic formulations for sustained celecoxib release.
M. M. Ibrahim (2013)
New Techniques for Drug Delivery to the Posterior Eye Segment
E. Eljarrat-Binstock (2009)
Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery
H. Gupta (2011)
Ophthalmic drug delivery systems—Recent advances
C. L. Bourlais (1998)
Microparticles and Nanoparticles in Ocular Drug Delivery
Murali K. Kothuri (2003)
Therapeutic Possibilities of Ceftazidime Nanoparticles in Devastating Pseudomonas Ophthalmic Infections; Keratitis and Endophthalmitis
M. Mohammadpour (2012)
Polymeric nanocapsules: a potential new therapy for corneal wound healing
S. Reimondez-Troitiño (2016)
Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods.
F. Qian (2001)
Pharmacologic Therapy of Ocular Disease
S. Whitcup (2017)
Dual Drug-Loaded Electrospun Nanofibres for the Treatment of Corneal Diseases
E. Tawfik (2019)
Influence of the Degrees of Hydrolyzation and Polymerization of Poly(vinylalchol)on the Preparation and Properties of Poly(DL-lactide-co-glycolide)nanoparticle.
Murakami (1997)
Penetration of Amikacin into Aqueous Humor of Rabbits
E. Erkin (2001)
Polymer‐based carriers for ophthalmic drug delivery
Julieta C. Imperiale (2018)
Study of the mechanism of interaction of poly(ϵ-caprolactone) nanocapsules with the cornea by confocal laser scanning microscopy
P. Calvo (1994)
Intraocular penetration of antimicrobial agents in ophthalmic infections and drug delivery strategies
T. Velpandian (2009)
Natural Bioadhesive Biodegradable Nanoparticle-Based Topical Ophthalmic Formulations for Management of Glaucoma.
M. M. Ibrahim (2015)
Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application.
R. Pignatello (2002)
Polymeric nanoparticulate system: a potential approach for ocular drug delivery.
R. C. Nagarwal (2009)
Chitosan-based nanostructures: a delivery platform for ocular therapeutics.
M. de la Fuente (2010)
A Review of In Vitro Drug Release Test Methods for Nano-Sized Dosage Forms
Susan D'Souza (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar