Online citations, reference lists, and bibliographies.
← Back to Search

Commercial Quantities Of Ultrasmall Fluorescent Nanodiamonds Containing Color Centers

O. Shenderova, Nicholas Nunn, Thomas Oeckinghaus, M. Torelli, G. McGuire, K. Smith, E. Danilov, R. Reuter, J. Wrachtrup, A. Shames, Daria Filonova, A. Kinev
Published 2017 · Materials Science, Engineering

Cite This
Download PDF
Analyze on Scholarcy
Share
Optically active nanodiamond particles remain one of the most popular research topics due to the photoluminescent properties of crystallographic defects in the diamond lattice, referred to as color centers. A number of groups are currently undertaking efforts to commercialize this material. Recently, our group succeeded in large-scale production of fluorescent diamond particles containing nitrogen-vacancy (NV) color centers in hundred-gram per batch scales using irradiation with 2-3 MeV electrons. Production of ND-NV fractions with median sizes ranging between 10 nm and 100 nm was achieved. While 100 nm fluorescent nanodiamonds (FNDs) are ~10x brighter than a conventional dye (Atto 532), the brightness of FNDs drops with decreasing particle size. Because of this, significant efforts must be undertaken to elucidate the size/brightness compromise and identify relevant application niches for FND in bioimaging and biolabeling. In order for a new material to be considered for applications in the overcrowded optical reagent market, the reagent must be convenient to use by an end user from the biomedical community, be validated both in vitro and in vivo, and offer measurable and significant (rather than incremental) benefit to end users in specific applications. This paper reports on the characteristics of the ultrasmall (10-40nm) and larger fluorescent nanodiamonds as well as our efforts toward their adaptation for use in the biological science community.
This paper references
10.1002/anie.201506556
Diamond Quantum Devices in Biology.
Y. Wu (2016)
10.1021/ar200037t
Biomedical applications of tetrazine cycloadditions.
N. Devaraj (2011)
H J von Bardeleben
A I Shames (2015)
V Scanning confocal optical microscopy and magnetic resonance on single defect centres
A Gruber (2012)
10.1517/17425247.2015.992412
Nanodiamond-mediated drug delivery and imaging: challenges and opportunities
V. Vaijayanthimala (2015)
10.1021/BC060077Y
Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability.
Seungpyo Hong (2006)
10.1088/0022-3727/48/15/155302
Magnetic resonance tracking of fluorescent nanodiamond fabrication
A. Shames (2015)
Metal-Free Click Chemistry
J. Escorihuela (2015)
10.1039/c3cs60049a
Inverse electron demand Diels-Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme.
Astrid-Caroline Knall (2013)
10.1126/SCIENCE.276.5321.2012
Scanning confocal optical microscopy and magnetic resonance on single defect centers
A. Gruber (1997)
10.1038/nnano.2008.99
Mass production and dynamic imaging of fluorescent nanodiamonds.
Yi-Ren Chang (2008)
10.1146/annurev-physchem-040513-103659
Nitrogen-vacancy centers in diamond: nanoscale sensors for physics and biology.
R. Schirhagl (2014)
10.1016/j.biomaterials.2014.03.041
Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells.
L. Zhao (2014)
10.1016/j.biomaterials.2014.12.007
Plasma hydrogenated cationic detonation nanodiamonds efficiently deliver to human cells in culture functional siRNA targeting the Ewing sarcoma junction oncogene.
J. Bertrand (2015)
10.1021/JA0567081
Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity.
Shu-Jung Yu (2005)
10.1016/j.colsurfb.2013.05.026
Direct grafting of anti-fouling polyglycerol layers to steel and other technically relevant materials.
T. Weber (2013)
10.1002/ADOM.201600212
Brightness and photostability of emerging red and near-IR fluorescent nanomaterials for bioimaging
Philipp Reineck (2016)
10.1088/0957-4484/20/23/235602
High yield fabrication of fluorescent nanodiamonds.
J. Boudou (2009)
10.1007/978-3-662-04548-0
Optical properties of diamond
A. Zaitsev (2001)
10.1021/JA00076A032
Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers
K. Prime (1993)
10.1016/J.DIAMOND.2013.06.019
Hyperbranched polyglycerol modified fluorescent nanodiamond for biomedical research
J. Boudou (2013)
10.1091/mbc.E16-05-0330
madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy
Jason Yi (2016)
10.1021/acs.accounts.5b00484
Fluorescent Nanodiamond: A Versatile Tool for Long-Term Cell Tracking, Super-Resolution Imaging, and Nanoscale Temperature Sensing.
W. Hsiao (2016)
10.1021/jp9033936
Cationic nanoparticles induce nanoscale disruption in living cell plasma membranes.
Jiumei Chen (2009)
10.1016/j.physrep.2013.02.001
The nitrogen-vacancy colour centre in diamond
M. Doherty (2013)
10.1016/J.DIAMOND.2007.06.003
Paramagnetic defects and exchange coupled spins in pristine ultrananocrystalline diamonds
V. Osipov (2007)
10.1002/smll.201101193
Nanodiamond as a vector for siRNA delivery to Ewing sarcoma cells.
A. Alhaddad (2011)
10.1021/nn800870r
Poly(ethylene glycol) carbodiimide coupling reagents for the biological and chemical functionalization of water-soluble nanoparticles.
Hongyan Shen (2009)
10.1103/PhysRevB.87.235436
Spin relaxometry of single nitrogen-vacancy defects in diamond nanocrystals for magnetic noise sensing
J. Tetienne (2013)
10.1002/ADMI.201500135
Metal‐Free Click Chemistry Reactions on Surfaces
Jorge Escorihuela (2015)
10.1007/978-3-642-37490-6
HPHT-Treated Diamonds
I. Dobrinets (2013)
10.1002/ADFM.201301075
Highly Fluorescent Nanodiamonds Protein-Functionalized for Cell Labeling and Targeting
Be-Ming Chang (2013)
10.1021/JA047642X
Covalently modified silicon and diamond surfaces: resistance to nonspecific protein adsorption and optimization for biosensing.
Tami L. Lasseter (2004)
10.1021/JP205389M
Hydroxylated Detonation Nanodiamond: FTIR, XPS, and NMR Studies
Olga Shenderova (2011)
Bioconjugate Techniques
G. T. Hermanson (2013)
10.1021/ja8053805
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.
Melissa L. Blackman (2008)



This paper is referenced by
10.1002/smll.201902151
A Perspective on Fluorescent Nanodiamond Bioimaging.
M. Torelli (2019)
10.1016/j.physb.2019.411868
Toward production of diamond particles with improved fluorescence uniformity
O. Shenderova (2020)
10.1016/j.jconrel.2017.05.033
Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions
J. Whitlow (2017)
10.1088/1361-6528/ab283d
The effect of particle size on nanodiamond fluorescence and colloidal properties in biological media.
E. Wilson (2019)
10.1016/j.actbio.2019.10.037
Carboxylated nanodiamond-mediated CRISPR-Cas9 delivery of human retinoschisis mutation into human iPSCs and mouse retina.
Tien-Chun Yang (2019)
10.1117/12.2281681
Preparation of fluorescent nanodiamond suspensions using bead-assisted ultrasonic disintegration
Maciej J. Głowacki (2017)
10.3389/fphy.2020.00205
High Temperature Treatment of Diamond Particles Toward Enhancement of Their Quantum Properties
M. Torelli (2020)
10.1002/jbm.a.36868
Nanodiamond in composite: Biomedical application.
A. Rehman (2019)
10.1016/j.carbon.2020.03.057
Explosive Fragmentation of Luminescent Diamond Particles.
Ibrahim M. Abdullahi (2020)
10.1515/nanoph-2018-0025
Fluorescent nanodiamonds: past, present, and future
M. Alkahtani (2018)
10.1088/2050-6120/aac0c8
Fluorescent single-digit detonation nanodiamond for biomedical applications.
Nicholas Nunn (2018)
10.1021/acs.analchem.7b03236
Recombinant Protein Polymers for Colloidal Stabilization and Improvement of Cellular Uptake of Diamond Nanosensors.
T. Zheng (2017)
Semantic Scholar Logo Some data provided by SemanticScholar