Online citations, reference lists, and bibliographies.
← Back to Search

Caspases: Enemies Within.

N. Thornberry, Y. Lazebnik
Published 1998 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
This paper references
10.1038/356397A0
Social controls on cell survival and cell death
M. Raff (1992)
10.1016/0092-8674(92)90223-Y
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
C. Ray (1992)
10.1038/356768A0
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Nancy A. Thornberry (1992)
10.1016/0092-8674(93)90485-9
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
J. Yuan (1993)
10.1038/370270A0
Structure and mechanism of interleukin-lβ converting enzyme
K. Wilson (1994)
10.1016/0092-8674(94)90303-4
Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer
N.P.C. Walker (1994)
10.1038/377248A0
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
D. Xue (1995)
10.1073/PNAS.92.19.8744
Mathematical analysis of activation thresholds in enzyme-catalyzed positive feedbacks: application to the feedbacks of blood coagulation.
E. Beltrami (1995)
10.1126/SCIENCE.7569933
Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.
N. Bump (1995)
10.1002/j.1460-2075.1995.tb07184.x
Interleukin‐1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.
Y. Gu (1995)
10.1073/PNAS.93.16.8395
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
A. Takahashi (1996)
10.1016/S0092-8674(00)80085-9
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
X. Liu (1996)
10.1074/jbc.271.28.16443
The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A*
K. Orth (1996)
10.1038/NSB0796-619
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
J. Rotonda (1996)
10.1016/S0968-0004(97)01085-2
Caspases: killer proteases.
D. Nicholson (1997)
10.1038/36889
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
D. Xue (1997)
10.1126/SCIENCE.278.5336.294
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis.
S. Kothakota (1997)
10.1016/S1074-7613(00)80450-1
Casper is a FADD- and caspase-related inducer of apoptosis.
H. Shu (1997)
10.1002/BIES.950190609
Death substrates come alive
A. Porter (1997)
10.1038/40657
Inhibition of death receptor signals by cellular FLIP
M. Irmler (1997)
10.1038/40901
X-linked IAP is a direct inhibitor of cell-death proteases
Q. Deveraux (1997)
10.1073/PNAS.94.25.13606
Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1.
S. Seshagiri (1997)
10.1126/SCIENCE.278.5345.1966
Conversion of Bcl-2 to a Bax-like death effector by caspases.
E. Cheng (1997)
10.1074/jbc.272.41.26056
Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis*
L. Wen (1997)
10.1126/SCIENCE.276.5318.1571
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
T. Rudel (1997)
10.1074/jbc.272.29.17907
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
N. Thornberry (1997)
10.1074/jbc.272.47.29449
Specific Proteolysis of the Kinase Protein Kinase C-related Kinase 2 by Caspase-3 during Apoptosis
V. Cryns (1997)
10.1016/S0092-8674(00)80197-X
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
X. Liu (1997)
10.1093/emboj/16.21.6346
The large subunit of replication factor C is a substrate for caspase‐3 in vitro and is cleaved by a caspase‐3‐like protease during Fas‐mediated apoptosis
É. Rhéaume (1997)
10.1126/SCIENCE.281.5381.1309
Mitochondria and apoptosis.
D. Green (1998)
10.1016/S1074-5521(98)90615-9
Caspases: key mediators of apoptosis.
N. Thornberry (1998)
10.1038/35385
Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
F. F. Davidson (1998)
10.1126/SCIENCE.281.5381.1317
A matter of life and cell death.
G. Evan (1998)
10.1073/PNAS.95.9.5156
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
T. Koseki (1998)
10.1126/SCIENCE.281.5381.1305
Death receptors: signaling and modulation.
A. Ashkenazi (1998)
10.1016/S0968-0004(98)01198-0
Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts.
A. Uren (1998)
10.1016/S1097-2765(00)80032-5
Autoproteolytic activation of pro-caspases by oligomerization.
X. Yang (1998)
10.1074/JBC.273.5.2926
An Induced Proximity Model for Caspase-8 Activation*
M. Muzio (1998)
10.1038/34112
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
M. Enari (1998)
10.1093/emboj/17.8.2215
IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases
Q. Deveraux (1998)
10.1101/GAD.12.11.1551
Proteases to die for.
V. Cryns (1998)



This paper is referenced by
10.3390/ijms221910309
Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling
Chen-Sheng Chen (2021)
10.1007/s11356-021-15985-x
Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell
C. Alimba (2021)
10.20944/preprints202108.0167.v1
LED Induced Microglial Activation and Rise in Caspase3 Shows Reorganization in the Retina
B. Balogh (2021)
10.3390/cancers13194989
Anticancer Mechanisms of Bioactive Compounds from Solanaceae: An Update
D. Nkwe (2021)
10.1111/cbdd.13849
Multiple interactions between melatonin and non‐coding RNAs in cancer biology
M. Maleki (2021)
10.1016/j.vetmic.2021.109129
Caprine parainfluenza virus type 3 N protein promotes viral replication via inducing apoptosis.
Jizong Li (2021)
10.1016/j.isci.2021.102439
Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex
N. A. Salem (2021)
10.1016/j.bjorl.2021.05.010
The circadian timing of noise exposure influences noise-induced inflammatory responses in the mouse cochlea.
Shichang Li (2021)
10.3390/molecules26133926
The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells
Chen Chen (2021)
10.3390/BIOMEDINFORMATICS1010003
High Expression of Caspase-8 Associated with Improved Survival in Diffuse Large B-Cell Lymphoma: Machine Learning and Artificial Neural Networks Analyses
J. Carreras (2021)
10.3389/fchem.2021.522708
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS
Yinghui Shang (2021)
10.2147/DDDT.S304128
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo
Leilei Ding (2021)
10.1002/fsn3.2317
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity
Shubo Zhou (2021)
10.1016/j.devcel.2021.06.008
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
Roi Ankawa (2021)
10.1016/j.jbc.2021.100445
Protein kinase C fusion proteins are paradoxically loss of function in cancer
A. N. Van (2021)
10.3390/ijms221910418
LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina
B. Balogh (2021)
10.3390/ph14040376
Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy
D. Persike (2021)
10.1186/s40659-020-00324-0
Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells
M. Alkhateeb (2021)
10.1016/j.leukres.2021.106523
Assessment of azithromycin as an anticancer agent for treatment of imatinib sensitive and resistant CML cells.
T. Ozkan (2021)
10.1038/s41417-021-00328-2
Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway.
Hong Liu (2021)
10.3390/molecules26154699
N-Terminomics Strategies for Protease Substrates Profiling
M. Mintoo (2021)
10.1016/j.biopha.2021.111675
Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats.
Mona F. Mahmoud (2021)
10.3892/ol.2020.12327
Effects of matrine in combination with cisplatin on liver cancer
Gaoyu Hu (2021)
10.21608/zvjz.2021.66481.1141
Mir-140 and Mir-34a as Molecular Markers for Apoptotic Brain in Sunset Yellow and Carmoisine Intoxicated Mice
Mohamed Hussein (2021)
10.1016/j.sjbs.2021.04.017
Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway
Yan Zhang (2021)
10.1016/j.sjbs.2021.04.052
Anticancer and immunomodulatory effect of rhaponticin on Benzo(a)Pyrene-induced lung carcinogenesis and induction of apoptosis in A549 cells
Xiaodong Wang (2021)
10.3390/toxins13070506
Cell Death and Metabolic Stress in Gymnodinium catenatum Induced by Allelopathy
L. J. Fernández-Herrera (2021)
10.1039/D0SC05860B
Leveraging autocatalytic reactions for chemical domain image classification†
Christopher E. Arcadia (2021)
10.7150/jca.55791
RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice
Ge Zhang (2021)
10.1021/acsomega.1c03080
Bioactivity Studies of Hesperidin and XAV939
A. Fazary (2021)
10.3390/cells10061454
Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the Drosophila Ovary
D. P. V. Lebo (2021)
10.1155/2021/8814862
Downregulation of microRNA-15b-5p Targeting the Akt3-Mediated GSK-3β/β-Catenin Signaling Pathway Inhibits Cell Apoptosis in Parkinson's Disease
J. Zhu (2021)
See more
Semantic Scholar Logo Some data provided by SemanticScholar