← Back to Search
Caspases: Enemies Within.
N. Thornberry, Y. Lazebnik
Published 1998 · Biology, Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
This paper references
Social controls on cell survival and cell death
M. Raff (1992)
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
C. Ray (1992)
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Nancy A. Thornberry (1992)
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
J. Yuan (1993)
Structure and mechanism of interleukin-lβ converting enzyme
K. Wilson (1994)
Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer
N.P.C. Walker (1994)
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
D. Xue (1995)
Mathematical analysis of activation thresholds in enzyme-catalyzed positive feedbacks: application to the feedbacks of blood coagulation.
E. Beltrami (1995)
Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.
N. Bump (1995)
Interleukin‐1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.
Y. Gu (1995)
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
A. Takahashi (1996)
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
X. Liu (1996)
The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A*
K. Orth (1996)
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
J. Rotonda (1996)
Caspases: killer proteases.
D. Nicholson (1997)
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
D. Xue (1997)
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis.
S. Kothakota (1997)
Casper is a FADD- and caspase-related inducer of apoptosis.
H. Shu (1997)
Death substrates come alive
A. Porter (1997)
Inhibition of death receptor signals by cellular FLIP
M. Irmler (1997)
X-linked IAP is a direct inhibitor of cell-death proteases
Q. Deveraux (1997)
Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1.
S. Seshagiri (1997)
Conversion of Bcl-2 to a Bax-like death effector by caspases.
E. Cheng (1997)
Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis*
L. Wen (1997)
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
T. Rudel (1997)
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
N. Thornberry (1997)
Specific Proteolysis of the Kinase Protein Kinase C-related Kinase 2 by Caspase-3 during Apoptosis
V. Cryns (1997)
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
X. Liu (1997)
The large subunit of replication factor C is a substrate for caspase‐3 in vitro and is cleaved by a caspase‐3‐like protease during Fas‐mediated apoptosis
É. Rhéaume (1997)
Mitochondria and apoptosis.
D. Green (1998)
Caspases: key mediators of apoptosis.
N. Thornberry (1998)
Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
F. F. Davidson (1998)
A matter of life and cell death.
G. Evan (1998)
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
T. Koseki (1998)
Death receptors: signaling and modulation.
A. Ashkenazi (1998)
Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts.
A. Uren (1998)
Autoproteolytic activation of pro-caspases by oligomerization.
X. Yang (1998)
An Induced Proximity Model for Caspase-8 Activation*
M. Muzio (1998)
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
M. Enari (1998)
IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases
Q. Deveraux (1998)
Proteases to die for.
V. Cryns (1998)
This paper is referenced by
Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling
Chen-Sheng Chen (2021)
Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell
C. Alimba (2021)
LED Induced Microglial Activation and Rise in Caspase3 Shows Reorganization in the Retina
B. Balogh (2021)
Anticancer Mechanisms of Bioactive Compounds from Solanaceae: An Update
D. Nkwe (2021)
Multiple interactions between melatonin and non‐coding RNAs in cancer biology
M. Maleki (2021)
Caprine parainfluenza virus type 3 N protein promotes viral replication via inducing apoptosis.
Jizong Li (2021)
Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex
N. A. Salem (2021)
The circadian timing of noise exposure influences noise-induced inflammatory responses in the mouse cochlea.
Shichang Li (2021)
The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells
Chen Chen (2021)
High Expression of Caspase-8 Associated with Improved Survival in Diffuse Large B-Cell Lymphoma: Machine Learning and Artificial Neural Networks Analyses
J. Carreras (2021)
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS
Yinghui Shang (2021)
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo
Leilei Ding (2021)
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity
Shubo Zhou (2021)
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
Roi Ankawa (2021)
Protein kinase C fusion proteins are paradoxically loss of function in cancer
A. N. Van (2021)
LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina
B. Balogh (2021)
Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy
D. Persike (2021)
Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells
M. Alkhateeb (2021)
Assessment of azithromycin as an anticancer agent for treatment of imatinib sensitive and resistant CML cells.
T. Ozkan (2021)
Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway.
Hong Liu (2021)
N-Terminomics Strategies for Protease Substrates Profiling
M. Mintoo (2021)
Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats.
Mona F. Mahmoud (2021)
Effects of matrine in combination with cisplatin on liver cancer
Gaoyu Hu (2021)
Mir-140 and Mir-34a as Molecular Markers for Apoptotic Brain in Sunset Yellow and Carmoisine Intoxicated Mice
Mohamed Hussein (2021)
Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway
Yan Zhang (2021)
Anticancer and immunomodulatory effect of rhaponticin on Benzo(a)Pyrene-induced lung carcinogenesis and induction of apoptosis in A549 cells
Xiaodong Wang (2021)
Cell Death and Metabolic Stress in Gymnodinium catenatum Induced by Allelopathy
L. J. Fernández-Herrera (2021)
Leveraging autocatalytic reactions for chemical domain image classification†
Christopher E. Arcadia (2021)
RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice
Ge Zhang (2021)
Bioactivity Studies of Hesperidin and XAV939
A. Fazary (2021)
Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the Drosophila Ovary
D. P. V. Lebo (2021)
Downregulation of microRNA-15b-5p Targeting the Akt3-Mediated GSK-3β/β-Catenin Signaling Pathway Inhibits Cell Apoptosis in Parkinson's Disease
J. Zhu (2021)See more