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Amplification Of A Novel V-erbB-related Gene In A Human Mammary Carcinoma.
C. R. King, M. Kraus, S. Aaronson
Published 1985 · Biology, Medicine
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The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related to v-erbB but amplified in a manner that appeared to distinguish it from the gene for the EGF receptor. Molecular cloning of this DNA segment and nucleotide sequence analysis revealed the presence of two putative exons in a DNA segment whose predicted amino acid sequence was closely related to, but different from, the corresponding sequence of the erbB/EGF receptor. Moreover, this DNA segment identified a 5-kilobase transcript distinct from the transcripts of the EGF receptor gene. Thus, a new member of the tyrosine kinase proto-oncogene family has been identified on the basis of its amplification in a human mammary carcinoma.
This paper references
Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation
A. Gazit (1984)
Retroviral transforming genes in normal cells?
P. Duesberg (1983)
RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.
H. Lehrach (1977)
Scrapie prions aggregate to form amyloid-like birefringent rods
S. Prusiner (1983)
Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).
J. Smart (1981)
Cellular oncogenes and retroviruses.
J. Bishop (1983)
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen
Alan L. Schechter (1984)
Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes
A. Hampe (1982)
Transformation of NIH 3T3 cells by a human c-sis cDNA clone
M. Clarke (1984)
Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.
S. Collins (1983)
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
A. Ullrich (1985)
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
E. Chang (1982)
Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses
M. Shibuya (1982)
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
E. Schwab (1983)
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
A. Ullrich (1984)
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
M. Schwab (1984)
Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus
N. Kitamura (1982)
Expression of human fibroblast interferon gene in Escherichia coli
R. Derynck (1980)
Organization and expression of eucaryotic split genes coding for proteins.
R. Breathnach (1981)
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
P. Rigby (1977)
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.
R. Taub (1982)
Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.
E. P. Reddy (1983)
Detection of specific sequences among DNA fragments separated by gel electrophoresis.
E. M. Southern (1975)
The erbB gene of avian erythroblastosis virus is a member of the src gene family
T. Yamamoto (1983)
Repression of rearranged mu gene and translocated c-myc in mouse 3T3 cells X Burkitt lymphoma cell hybrids.
K. Nishikura (1984)
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
A. Klein (1982)
Rapid and sensitive protein similarity searches.
D. Lipman (1985)
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
M. Waterfield (1983)
Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene
J. Drebin (1984)
Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.
C. Lin (1984)
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
T. Libermann (1985)
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.
G. Wahl (1979)
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
R. Doolittle (1983)
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
J. Downward (1984)
Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution.
U. Schibler (1975)
A new method for sequencing DNA.
A. Maxam (1977)
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M. Burotto (2019)
Estrogen and oncogene mediated growth regulation of human breast cancer cells.
A. Kasid (1987)
Structure and expression of oncogenes in surgical specimens of human breast carcinomas.
I. Biunno (1988)
Expression of the c‐Ha‐ras and neu oncogenes in DMBA‐induced, anti‐estrogen‐treated rat mammary tumors
T. Vuorio (1988)
Tumorigenic Conversion of in vivo Differentiation Competent Mammary Cells by Introduction and Expression of ras or mil(raf) but not myc
W. Günzburg (1989)
Epidermal growth factor receptors in breast cancer: association with early relapse and death, poor response to hormones and interactions with neu.
A. Harris (1989)
Detection of the HER-2/neu proto-oncogene protein p185erbB2 by a novel monoclonal antibody (MAB-145ww) in breast cancer membranes from oestrogen and progesterone receptor assays.
M. W. Beckmann (1992)
Growth factors and cancer.
S. Aaronson (1991)
Establishment of the human BSMZ breast cancer cell line, which overexpresses the erbB-2 and c-myc genes.
M. Watanabe (1992)
Expression of epidermal growth factor receptor and transforming growth factor alpha in human larynx carcinoma.
E. di Marco (1992)
c‐erbB‐2 oncoprotein is not an independent prognostic parameter in primary breast carcinoma. An immunohistochemical study
T. Haerslev (1994)
Analysis of the genes for oestrogen and epidermal growth factor receptors in human breast cancer
A. Sharma (1996)
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXIV. Repeated embryonic genes in liver.
R. Hancock (1991)
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer.
F. Esteva (2002)
Cáncer de mama: utilidad pronóstica de los nuevos marcadores tumorales Breast cancer: prognostic value of the new tumor markers
García Vilaa (2003)
Oncogenic Receptor Tyrosine Kinases
M. Kirschbaum (2003)
Aus der Medizinischen Universitätsklinik und
P. Tübingen (2005)
Nachweis von disseminierten Tumorzellen im Knochenmark bei Patientinnen mit primärem, nicht- metastasiertem Mammakarzinom und Charakterisierung der Her-2/neu- Expression über immunzytochemische Doppelfärbungen
Ä. Direktor (2006)
The role of platinum-based therapy for HER-2-positive breast cancer
A. Joy (2006)
Short form of the heparin-binding EGF-like growth factor: Communication II
E. Loukianov (2006)
Traitements néo-adjuvants des cancers du sein HER2 positif
B. Coudert (2007)
655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations
S. Tommasi (2007)
Chapter 2 – Physiological Structure and Function of Proteins
M. Pincus (2012)
Monoclonal Antibodies for Cancer Therapy and Prevention: Paradigm Studies in Targeting the neu/ERBB2/HER2 Oncoprotein
H. Zhang (2013)
Enhanced anti-proliferative activity of the combination of tamoxifen plus HER-2-neu antibody
L. Witters (2004)
HER 2 Inhibition : From Discovery to Clinical Practice 55 Commentary on Buzdar
J. C. Chang (2006)
Leads to the Identification of Novel Candidate Genes than Conventional Comparative Genomic Hybridization and Incidence of Genomic Amplifications in Pancreatic Cancer Genomic DNA-Chip Hybridization Reveals a Higher
K. Holzmann (2004)
Development of new targeted therapies for breast cancer
D. Doyle (2008)
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.
C. T. Guy (1994)
The role of growth factors and growth factor receptors in neoplastic cell transformation
P. P. D. Fiore (1988)
Developmental activities of the epidermal growth factor receptor.
E. Adamson (1990)
The Human Carcinoid Cell Line, BON
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