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Detection Of Smoking-related Covalent DNA Adducts In Human Placenta.

R. Everson, E. Randerath, R. Santella, R. Cefalo, T. A. Avitts, K. Randerath
Published 1986 · Chemistry, Medicine

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The presence of covalent DNA chemical addition products (adducts) in human term placentas was investigated by recently developed immunologic and 32P-postlabeling assays. DNA from placental specimens of smokers showed a small but not statistically significant increase in adduct levels when tested by antibodies to DNA modified with a benzo[a]pyrene dihydrodiol epoxide (BPDE-I), the ultimate carcinogenic derivative of benzo[a]pyrene. The postlabeling assay detected several modified nucleotides, one of which (adduct 1) strongly related to maternal smoking during pregnancy. This adduct was present in placental tissue from 16 of 17 smokers, but only 3 of 14 nonsmokers. Among smokers, levels of adduct 1 in general were only weakly related to questionnaire and biochemical measures of the intensity of smoking exposures, which suggests modulation by individual susceptibility factors. The adduct seemed to be derived from an aromatic carcinogen, but it may not result from several of the most intensely studied polycyclic aromatic hydrocarbons or aromatic amines in tobacco smoke. The data show the association of cigarette smoking with covalent damage to human DNA in vivo.
This paper references
In vivo dosimetry of 4-aminobiphenyl in rats via a cysteine adduct in hemoglobin.
L. C. Green (1984)
10.1093/CARCIN/5.2.231
32P-postlabeling test for covalent DNA binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agents.
M. V. Reddy (1984)
10.1126/SCIENCE.6823565
Implication of nonlinear kinetics on risk estimation in carcinogenesis.
D. Hoel (1983)
10.1016/S0140-6736(80)90007-0
INDIVIDUALS TRANSPLACENTALLY EXPOSED TO MATERNAL SMOKING MAY BE AT INCREASED CANCER RISK IN ADULT LIFE
R. Everson (1980)
10.1093/OXFORDJOURNALS.AJE.A114018
Risk factors for gestational trophoblastic disease in Italy.
C. la Vecchia (1985)
10.1126/science.160.3827.541
Cigarette Smoking: Stimulatory Effect on Metabolism of 3,4-Benzpyrene by Enzymes in Human Placenta
R. Welch (1968)
10.1093/OXFORDJOURNALS.AJE.A112802
Gross differences observed in the placentas of smokers and nonsmokers.
R. Christianson (1979)
10.1016/0021-9681(82)90078-9
Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation.
F. Perera (1982)
Detection of benzo(a)pyrene:DNA adducts in human white blood cells.
A. Shamsuddin (1985)
10.1093/CARCIN/3.9.1081
32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts.
R. C. Gupta (1982)
10.1093/CARCIN/6.8.1117
32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene.
E. Randerath (1985)
Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women.
D. Nebert (1969)
10.1016/0009-2797(84)90027-9
Ubiquitous binding of benzo[a]pyrene metabolites to DNA and protein in tissues of the mouse and rabbit.
S. J. Stowers (1984)
10.1093/CARCIN/5.3.373
Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide.
R. Santella (1984)
10.1093/CARCIN/3.12.1405
A pilot project in molecular cancer epidemiology: determination of benzo[a]pyrene--DNA adducts in animal and human tissues by immunoassays.
F. Perera (1982)
Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay.
M. Poirier (1980)
Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions.
D. Hoffmann (1985)



This paper is referenced by
10.1007/BF03324175
Theories of aging
C. Finch (1993)
10.1007/978-981-10-5657-4
Ambient Air Pollution and Health Impact in China
G. Dong (2017)
10.1016/J.PLACENTA.2004.09.006
Human placenta: a human organ for developmental toxicology research and biomonitoring.
P. Myllynen (2005)
10.1016/0165-1218(88)90022-5
Application of new techniques for the detection of carcinogen adducts to human population monitoring.
R. Santella (1988)
10.1016/j.humpath.2013.07.024
Smoking during pregnancy causes double-strand DNA break damage to the placenta.
T. Slatter (2014)
10.1007/BF01234663
Estimation of exposure of man to substances reacting covalently with macromolecules
P. Farmer (2005)
Analysis of deoxyribonucleic acid adducts in workers.
K. Szyfter (1992)
4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms
Toxicokinetics (2008)
10.1007/978-1-4020-6704-4_16
Smoking and Lung Cancer
J. Stavridis (2008)
10.1016/0027-5107(94)90221-6
Elevated frequencies of hprt mutant lymphocytes in cigarette-smoking mothers and their newborns.
M. Ammenheuser (1994)
10.2307/3430463
32P-postlabeling assay for carcinogen-DNA adducts: nuclease P1-mediated enhancement of its sensitivity and applications.
M. V. Reddy (1987)
10.3748/WJG.15.817
Excretion of biliary compounds during intrauterine life.
R. Macias (2009)
10.1016/S0009-2797(00)00195-2
DNA adduct formation by Fusarium culture extracts: lack of role of fusarin C.
R. Bever (2000)
10.1289/EHP.93101S233
Transplacental transfer of genotoxins and transplacental carcinogenesis.
H. Autrup (1993)
10.1289/EHP.939983
DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality.
J. Mumford (1993)
10.1289/EHP.89819
Markers of exposure to carcinogens.
G. Wogan (1989)
10.3109/10915818909018048
Markers of Exposure to Carcinogens: Methods for Human Biomonitoring
G. Wogan (1989)
10.1002/IJC.2910520602
Smoking‐related dna adducts in human gastric cancers
G. W. Dyke (1992)
10.1016/0378-4274(92)90221-5
Advantages and limitations of laboratory methods for measurement of carcinogen-DNA adducts for epidemiological studies.
R. K. Kaderlik (1992)
10.1016/0165-1161(93)90138-P
Immunoaffinity concentration of human lung DNA adducts using an anti-benzo[a]pyrene-diol-epoxide-DNA antibody. Analysis by 32P-postlabelling or ELISA.
M. King (1993)
10.1093/CARCIN/14.3.493
Effect of turmeric and curcumin on BP-DNA adducts.
M. Mukundan (1993)
10.1007/BF00661366
Passively inhaled tobacco smoke: a challenge to toxicology and preventive medicine
H. Remmer (2004)
Chapter 5 — Reproductive and Developmental Effects from Exposure to Secondhand Smoke
(2006)
10.1096/fasebj.6.11.1644258
DNA adducts in humans as dosimeters of exposure to environmental, occupational, or dietary genotoxins 1
H. A. Schut (1992)
Reduced DNA repair capacity in head and neck cancer patients.
L. Cheng (1998)
10.1079/JOH200186
Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice.
S. Sheweita (2002)
10.1002/BDRA.20346
DNA adducts in human placenta exposed to ambient environment and passive cigarette smoke during pregnancy.
M. K. Sanyal (2007)
Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers.
F. Perera (1988)
10.3109/10915818809019511
Cancer Risk Assessment Strategies Based on Mechanisms of Action
J. Weisburger (1988)
10.1016/0378-4347(92)80540-7
32P-postlabelling and mass spectrometric methods for analysis of bulky, polyaromatic carcinogen-DNA adducts in humans.
G. Talaska (1992)
10.1142/9789812706782_0012
Molecular Epidemiology of DNA Repair and Cancer Susceptibility — A Review of Population-based Studies
Zhibin Hu (2007)
10.1016/0165-1218(89)90026-8
Childhood cancer and malignancies other than lung cancer related to passive smoking.
G. Pershagen (1989)
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