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PH-sensitive Liposomes: Possible Clinical Implications.

M. Yatvin, W. Kreutz, B. Horwitz, M. Shinitzky
Published 1980 · Chemistry, Medicine

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When pH-sensitive molecules are incorporated into liposomes, drugs can be specifically released from these vesicles by a change of pH in the ambient serum. Liposomes containing the pH-sensitive lipid palmitoyl homocysteine (PHC) were constructed so that the greatest pH differential (6.0 to 7.4) of drug release was obtained near physiological temperature. Such liposomes could be useful clinically if they enable drugs to be targeted to areas of the body in which pH is less than physiological, such as primary tumors and metastases or sites of inflammation and infection.
This paper references
10.1016/0005-2736(79)90042-7
The involvement of the lipid phase transition in the plasma-induced dissolution of multilamellar phosphatidylcholine vesicles.
G. Scherphof (1979)
10.1111/j.1749-6632.1978.tb22035.x
USE OF LIPOSOMES FOR THE ENHANCEMENT OF THE CYTOTOXIC EFFECTS OF CYTOSINE ARABINOSIDE *
E. Mayhew (1978)
10.1016/0005-2736(69)90040-6
Activation of glucose diffusion from egg lecithin liquid crystals by serum albumin.
C. Sweet (1969)
10.1126/SCIENCE.432641
Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors.
J. Weinstein (1979)
10.1126/SCIENCE.364652
Design of liposomes for enhanced local release of drugs by hyperthermia.
M. Yatvin (1978)
A MODIFICATION OF THE METHOD FOR DETERMINING METHIONINE IN PROTEINS
H. Baernstein (1934)
10.1038/265407a0
Targeting of drugs
G. Gregoriadis (1977)
10.1021/JA01589A025
Formation of Peptide Bonds by Aminolysis of Homocysteine Thiolactones1
R. Benesch (1956)
10.1007/BF00537296
Induced drug release from lipid vesicles in serum by pH-change
M. Yatvin (2004)
10.1016/0005-2736(89)90007-2
The use of aqueous space markers to determine the mechanism of interaction between phospholipid vesicles and cells.
F. Szoka (1979)
10.1093/JNCI/34.6.857
Modifications of the acid-base status of the internal milieu of tumors.
P. Gullino (1965)
10.1093/JNCI/3.5.495
Hydrogen-Ion Concentration of Normal Liver and Hepatic Tumors
H. Kahler (1943)
10.1111/j.1749-6632.1978.tb22037.x
EFFECTS OF ENTRAPMENT IN LIPOSOMES ON THE DISTRIBUTION, DEGRADATION AND EFFECTIVENESS OF METHOTREXATE IN VIVO
H. Kimelberg (1978)
10.1126/SCIENCE.835007
Liposome-cell interaction: transfer and intracellular release of a trapped fluorescent marker.
J. Weinstein (1977)



This paper is referenced by
Long-circulating and target-specific nanoparticles: theory to practice.
S. Moghimi (2001)
10.1002/MPO.2950100302
Hydrogen ion dynamics and cancer: an appraisal.
S. Harguindey (1982)
10.1016/0005-2736(93)90317-S
Plasma dependent pH sensitivity of liposomes containing sulfatide.
P. Viani (1993)
10.1211/0022357021771913
pH‐sensitive, serum‐stable and long‐circulating liposomes as a new drug delivery system
Myo-Sook Hong (2002)
10.1038/bjc.1993.375
pH in human tumour xenografts: effect of intravenous administration of glucose.
T. Volk (1993)
10.1517/13543776.13.8.1127
Innovations in liposomal formulations for antimicrobial therapy
R. Schiffelers (2003)
10.4028/www.scientific.net/AST.77.333
pH-Responsive Hyperbranched Copolymers from One-Pot RAFT Copolymerization of Propylacrylic Acid and Poly(ethylene glycol diacrylate)
H. Tai (2012)
10.1007/3-540-13483-2_1
Polymeric monolayers and liposomes as models for biomembranes
H. Bader (1985)
10.3109/08982109409037050
pH-Sensitive Liposomes
Chun-Jung Chu (1994)
Lipid Nanocapsules for brain targeting of Nimodipine
Karim Mohsen (2017)
10.1016/j.addr.2020.02.004
Hyperthermia and smart drug delivery systems for solid tumor therapy.
A. L. Seynhaeve (2020)
10.1016/j.jconrel.2019.09.018
Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release.
Marjan Abri Aghdam (2019)
10.1016/j.nano.2015.03.014
Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model.
J. Pacheco-Torres (2015)
10.3390/nano8110923
Nano-Mediated Photodynamic Therapy for Cancer: Enhancement of Cancer Specificity and Therapeutic Effects
Ivan Mfouo Tynga (2018)
10.1142/9781783267231_0010
Smart Lipid-Based Drug Delivery Systems
Paloma Benito-Gallo (2016)
10.1016/j.matpr.2020.05.810
Emerging applications of lectins in cancer detection and biomedicine
A. Gupta (2020)
10.1021/BI00334A004
Proton-induced fusion of oleic acid-phosphatidylethanolamine liposomes.
N. Düzgüneş (1985)
10.1016/0167-7799(89)90064-4
Selective targeting of drugs
M. Fiani (1989)
10.1016/S1569-2558(08)60386-0
Intercellular and Intracellular Targeting of Drugs
S. Cohen (1994)
10.1142/4552
Frontiers in human genetics : diseases and technologies
C. San (2001)
Theory of tunable pH sensitive vesicles consisting of anionic and cationic lipids or anionic and neutral lipids
X. Li (2000)
10.1211/jpp.61.02.0001
Review: doxorubicin delivery systems based on chitosan for cancer therapy
M. Tan (2009)
10.3390/mi11090788
Recent Advances in Liposome-Based Molecular Robots
K. Shoji (2020)
10.1016/B978-0-323-52729-3.00003-2
Chapter 3 – Liposomes
M. Shah (2017)
10.1126/science.1226338
Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Z. Cheng (2012)
10.1016/0168-3659(88)90037-5
Chemically self-regulated drug delivery systems
J. Heller (1988)
10.1016/S0376-7388(00)80633-X
pH-responsive permeability of polyamide capsule membrane coated with lipid molecules and amphiphilic polypeptides
K. Kono (1991)
10.1007/BF00431545
Photodynamic therapy of human bladder carcinoma cells in vitro with pH-sensitive liposomes as carriers for 9-acetoxy-tetra-n-propylporphycene
A. Aicher (2004)
10.1002/ANGE.19881000111
Molekulare Architektur und Funktion von polymeren orientierten Systemen – Modelle für das Studium von Organisation, Oberflächenerkennung und Dynamik bei Biomembranen
H. Ringsdorf (1988)
10.1201/B18654-5
Liposomes as a Drug Delivery System
Kacoli Banerjee (2015)
10.21037/5039
Emerging chemotherapy agents in lung cancer: nanoparticles therapeutics for non-small cell lung cancer
G. In (2015)
10.1016/j.chemphyslip.2017.12.007
Novel lipids with three C18-fatty acid chains and an amino acid head group for pH-responsive and sustained antibiotic delivery.
M. Jadhav (2018)
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