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Mechanisms Of Resistance To Quinupristin-Dalfopristin Among Isolates Of Enterococcus Faecium From Animals, Raw Meat, And Hospital Patients In Western Europe

Mehnam Soltani, David Beighton, John Philpott-Howard, Neil Woodford

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ABSTRACT Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, ≥32 μg/ml) was associated with the presence of vat (E) ( satG ) (14 isolates [50%]) or vat (D) ( satA ) (6 isolates [21%]). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 μg/ml). This suggests the presence of further mechanisms of resistance to quinupristin-dalfopristin in E. faecium .