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Initial Route Of Antigen Administration Alters The T-cell Cytokine Profile Produced In Response To The Mouse Pneumonitis Biovar Of Chlamydia Trachomatis Following Genital Infection
K. Kelly, E. Robinson, R. Rank
Published 1996 · Medicine, Biology
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A Th1-type response develops following vaginal infection with the mouse pneumonitis biovar of Chlamydia trachomatis (MoPn). Since the type of response, i.e., Th1 versus Th2, can be influenced by factors present during T-cell activation, we examined the effects of different routes of MoPn administration on the cytokine profile and resistance against infection following a MoPn vaginal challenge. A dominant Th1-type cytokine profile developed in mice given live MoPn via the intranasal, oral, and vaginal routes with ratios of gamma interferon-secreting cells to interleukin 4-secreting cells greater than 10. In contrast, mice injected subcutaneously produced a Th2-type profile with a gamma interferon/interleukin 4 ratio of only 0.7. These mice also had significantly higher anti-MoPn immunoglobulin G1 serum titers, confirming a Th2-type cytokine profile. Exposure of mice to live MoPn, by any route prior to vaginal challenge, resulted in a shortened course of infection. However, the subcutaneous group resolved the vaginal infection more slowly, with 60% (6 of 10 mice) of the mice still isolation positive 12 days after challenge compared with only 20% of mice given live MoPn by other routes. Administration of UV-inactivated MoPn did not provide protection against a vaginal challenge. The decreased ability to clear infection was not associated with a shift in the cytokine profile, since intranasal and oral administration of UV-inactivated MoPn resulted in a predominant Th1-type response. Taken together, these data indicate that the initial route of MoPn administration can direct the type of response produced after a local MoPn infection and thus influence the ability of the immune response to protect against subsequent infection.
This paper references
INOCULATION OF MAN WITH INCLUSION BLENNORRHEA VIRUS
B. Jones (1962)
On the control between cell-mediated, IgM and IgG immunity.
P. Bretscher (1974)
On the control between cell-mediated, IgM and IgG 4982
P. A. Bretscher (1974)
On the control between cell-mediated, IgM and IgG 4982 KELLY ET AL
P A Bretscher (1974)
Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues.
M. McDermott (1979)
Chlamydiae (Psittacosis-Lymphogranuloma Venereum-Trachoma Group)
J Schachter (1980)
Chlamydiae (Psittacosis-Lymphogranuloma VenereumTrachoma Group), p. 357–364
J. Schachter (1980)
Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis
H. Caldwell (1981)
Is There Immunity to Chlamydial Infections of the Human Genital Tract?
J. Schachter (1983)
Effect of Prior Sexually Transmitted Disease on the Isolation of Chlamydia trachomatis
B. Katz (1987)
Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity.
N. Byars (1987)
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens
P. Scott (1988)
The mucosal vascular addressin is a tissue-specific endothelial cell adhesion molecule for circulating lymphocytes
M. Nakache (1989)
Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.
M. Belosevic (1989)
Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay.
T. Taguchi (1990)
Lymphokine control of in vivo immunoglobulin isotype selection.
F. Finkelman (1990)
Adhesion receptors of the immune system
T. Springer (1990)
Extensive heterogeneity of the protein composition of Chlamydia trachomatis following serial passage in two different cell lines.
P. Goswami (1990)
The role of T cell subpopulations in resolution of chlamydial genital infection of mice
W. R. Bowie (1990)
The role of T cell subpopulations in resolution of chlamydial genital infection of mice, p. 241–244
K. H. Ramsey (1990)
Genital chlamydial infections: epidemiology and reproductive sequelae.
W. Cates (1991)
Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.
T. Gajewski (1991)
Regulation of immunity to parasites by T cells and T cell-derived cytokines.
A. Sher (1992)
IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. I. Influence of antigen concentration and antigen-presenting cell type.
R. Dekruyff (1992)
Animal models for the study of pelvic inflammatory disease, p. 85–111
D. L. Patton (1992)
Animal models for the study of pelvic inflammatory disease
D L Patton (1992)
Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response
J. Sypek (1993)
Homing of naive, memory and effector lymphocytes.
C. Mackay (1993)
Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.
J. Igietseme (1993)
Interleukin-12 and its role in the generation of TH1 cells.
G. Trinchieri (1993)
The role of antigen-presenting cells in the regulation of delayed-type hypersensitivity. II. Epidermal Langerhans' cells and peritoneal exudate macrophages.
Y. Morikawa (1993)
Influence of the estrous cycle on the development of upper genital tract pathology as a result of chlamydial infection in the guinea pig model of pelvic inflammatory disease.
R. Rank (1993)
Site-specific immunity to Leishmania major in SWR mice: the site of infection influences susceptibility and expression of the antileishmanial immune response
G. S. Nabors (1994)
Signals and signs for lymphocyte responses
C. Janeway (1994)
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
V. Kuchroo (1995)
The effect of route of inoculation on protection by killed vaccines in chickens.
T. Nakamura (1995)
Increased Incidence of Oviduct Pathology in the Guinea Pig After Repeat Vaginal Inoculation With the Chlamydial Agent of Guinea Pig Inclusion Conjunctivitis
R. Rank (1995)
High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.
J. Girard (1995)
Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells
A. Saoudi (1995)
The influence of the site of parasite inoculation on the development of Th1 and Th2 type immune responses in (BALB/c × C57BL/6) F1 mice infected with Leishmania major
G. S. Nabors (1995)
Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection
R. Morrison (1995)
CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract
H. Su (1995)
Local Th1-like responses are induced by intravaginal infection of mice with the mouse pneumonitis biovar of Chlamydia trachomatis
T. Cain (1995)
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
J. Vancott (1996)
Mosmann. 1993. Interleukin-10
K W Moore
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J. Perfettini (2019)
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Taylor B Poston (2018)
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S. Carrasco (2018)
Update on Chlamydia trachomatis Vaccinology
L. M. de la Maza (2017)
Expression of CXCR3 on Adaptive and Innate Immune Cells Contributes Oviduct Pathology throughout Chlamydia muridarum Infection
J. Jiang (2017)
A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function
Taylor B Poston (2017)
Comparison of subcutaneous versus intranasal immunization of male koalas (Phascolarctos cinereus) for induction of mucosal and systemic immunity against Chlamydia pecorum.
C. Waugh (2015)
Delivery of a Chlamydial Adhesin N-PmpC Subunit Vaccine to the Ocular Mucosa Using Particulate Carriers
A. Inic-Kanada (2015)
Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D
Yanyan Qu (2015)
Hidden in Plain Sight: Chlamydial Gastrointestinal Infection and Its Relevance to Persistence in Human Genital Infection
R. Rank (2014)
Corr et al. Steroids in Chlamydial Genital Tract Infection
Tammy E. Corr (2014)
Steroids Alone or as Adjunctive Therapy with Doxycycline Fail To Improve Oviduct Damage in Mice Infected with Chlamydia muridarum
Tammy E. Corr (2014)
Immunology of Genital Tract Infections
E. Weissenbacher (2014)
Chlamydiozy dróg moczowo-płciowych u ludzi Chlamydiosis of urogenitary tract in humans
Wydział Biologii (2014)
CD4+ T Cell Expression of MyD88 Is Essential for Normal Resolution of Chlamydia muridarum Genital Tract Infection
L. Frazer (2013)
IL‐23 Induces IL‐22 and IL‐17 Production in Response to Chlamydia muridarum Genital Tract Infection, but the Absence of these Cytokines does not Influence Disease Pathogenesis
L. Frazer (2013)
Characterizing the role of innate and adaptive immune responses in the pathogenesis of Chlamydia genital tract infection
Lauren C. Frazer (2013)
Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection.
Laxmi Yeruva (2013)
Development of the vault particle as a platform technology.
L. Rome (2013)
Chlamydia muridarum Essential for Normal Resolution of T Cell Expression of MyD 88 Is + CD 4
C. Frazer (2013)
Proteomic identification of immunodominant chlamydial antigens in a mouse model.
A. Teng (2012)
Manipulation Of Host Signal Transduction Pathways And Cytoskeleton Functions By Invasive Bacterium Listeria Monocytogenes And Chlamydia Trachomatis
Shahanawaz Jiwani (2012)
The Recall Response Induced by Genital Challenge with Chlamydia muridarum Protects the Oviduct from Pathology but Not from Reinfection
M. M. Riley (2012)
Plasmid-Cured Chlamydia caviae Activates TLR2-Dependent Signaling and Retains Virulence in the Guinea Pig Model of Genital Tract Infection
L. Frazer (2012)
J. Igietseme (2012)
Chlamydia muridarum Alters the Immune Environment of the Murine Genital Tract to be More Permissive for Infection with Neisseria gonorrhoeae in a Novel Coinfection Model
Rachel A. Vonck (2011)
Chlamydial Infection Increases Gonococcal Colonization in a Novel Murine Coinfection Model
Rachel A. Vonck (2011)
Enhanced Neutrophil Longevity and Recruitment Contribute to the Severity of Oviduct Pathology during Chlamydia muridarum Infection
L. Frazer (2011)
MyD88 Deficiency Leads to Decreased NK Cell Gamma Interferon Production and T Cell Recruitment during Chlamydia muridarum Genital Tract Infection, but a Predominant Th1 Response and Enhanced Monocytic Inflammation Are Associated with Infection Resolution
U. Nagarajan (2010)
Interleukin-17 Contributes to Generation of Th1 Immunity and Neutrophil Recruitment during Chlamydia muridarum Genital Tract Infection but Is Not Required for Macrophage Influx or Normal Resolution of Infection
A. Scurlock (2010)
A new murine model for testing vaccines against genital Chlamydia trachomatis infections in males.
S. Pal (2010)
Infectivity Acts as In Vivo Selection for Maintenance of the Chlamydial Cryptic Plasmid
Marsha Y Russell (2010)See more